11Synthesis, crystal structures, electrochemistry and biological evaluation of tris(quinolin-8-olato) Mn(III) and Co(III) complexes methanol solvate

Shamle, Nathaniel J.; Tella, Adedibu C.; Obaleye, Joshua A.; Balogun, Fatai Oladunni; Ashafa, Anofi Omotayo Tom; Ajibade, Peter A.

doi:10.1016/j.molstruc.2020.128585

Cited by 6 publications

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“…Quinoline has several biological activities, including antimicrobial, , antifungal, antileishmaniasis, antimalarial, antioxidant, and anticancer effects. , The 8-hydroxyquinoline derivatives are effective targeted broad-spectrum drug molecule used to treat a wide range of life-threatening diseases, such as cancer, HIV infection, and neurodegenerative diseases, − and exert in vitro antitumor activity Various development and drug research centers are working to chemically or structurally modify their functional groups to construct broad-spectrum bioactive candidates. , …”

Section: Introductionmentioning

confidence: 99%

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(8-Hydroxyquinoline) Gallium(III) Complex with High Antineoplastic Efficacy for Treating Colon Cancer via Multiple Mechanisms

et al. 2023

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A series of (8-hydroxyquinoline) gallium(III) complexes (CP-1–4) was synthesized and characterized by single X-ray crystallography and density functional theory (DFT) calculation. The cytotoxicity of the four gallium complexes toward a human nonsmall cell lung cancer cell line (A549), human colon cancer cell line (HCT116), and human normal hepatocyte cell line (LO2) was evaluated using MTT assays. CP-4 exhibited excellent cytotoxicity against HCT116 cancer cells (IC50 = 1.2 ± 0.3 μM) and lower toxicity than cisplatin and oxaliplatin. We also evaluated the anticancer mechanism studies in cell uptake, reactive oxygen species analysis, cell cycle, wound-healing, and Western blotting assays. The results showed that CP-4 affected the expression of DNA-related proteins, which led to the apoptosis of cancer cells. Moreover, molecular docking tests of CP-4 were performed to predict other binding sites and to confirm its higher binding force to disulfide isomerase (PDI) proteins. The emissive properties of CP-4 suggest that this complex can be used for colon cancer diagnosis and treatment, as well as in vivo imaging. These results also provide a foundation for the development of gallium complexes as potent anticancer agents.

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Section: Introductionmentioning

confidence: 99%

“… 25 − 27 Various development and drug research centers are working to chemically or structurally modify their functional groups to construct broad-spectrum bioactive candidates. 33 , 34 …”

Section: Introductionmentioning

confidence: 99%