11P Convoluted role of H19 long non-coding RNA in regulating ICAM-1 and PVR in breast cancer patients

A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma

“…Moreover, this led in a significant increase in primary immune cells cytotoxicity upon co-culturing with transfected Huh7 cells. Our results were consistent with recent reports highlighting the immunomodulatory role of CCAT-1 [81] , H19 [32] and MALAT-1 [49] in several solid malignancies.…”

“…LncRNA H19 is another lncRNA that has been recently added to the list of emerging immunomodulatory lncRNAs through manipulating the expression profile of NK activating ligands on tumor cells and CD155 expression in several malignancies [ 11 , 30 , [32] , [33] , [34] , [35] ]. Furthermore, H19 has also been linked to tumor cell development, hypoxic stress, macrophage activation, chemotaxis, and differentiation [ 36 , 37 ].…”