[11C]choline PET/CT imaging in occult local relapse of prostate cancer after radical prostatectomy

Reske, Sven N.; Blumstein, N. M.; Glatting, Gerhard

doi:10.1007/s00259-007-0530-2

Cited by 157 publications

(101 citation statements)

References 30 publications

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“…The sensitivities of 18 F-choline PET/CT increased with increasing trigger PSA levels (77.5%, 80.7%, 85.2%, and 92.8% at trigger PSA levels of .0.5, 1.0, 2.0, and 4.0 ng/mL, respectively) and were higher in patients who were receiving ongoing ADT (85%) than in patients who were not (59.5%) (P 5 0.001) (36). Other investigators have suggested that ADT may be withheld before examination to reduce the risk of false-negative scans and thereby to increase the rate of detection by 18 F-choline PET/CT (5,10,27,37).…”

Section: Bone Metastasesmentioning

confidence: 99%

“…Various studies have investigated the diagnostic accuracy of 11 C-choline PET/CT for detecting PCa recurrence and have reported different values for sensitivity and specificity (5,(7)(8)(9)11,12,14). These variations could be attributed to the heterogeneity of patient populations in terms of inclusion criteria (i.e., PSA level, staging, and presence or absence of androgen deprivation therapy [ADT]).…”

Section: Influence Of Psa On Rate Of Detection By 11 C-choline Pet/ctmentioning

confidence: 99%

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¹¹C- or ¹⁸F-Choline PET/CT for Imaging Evaluation of Biochemical Recurrence of Prostate Cancer

et al. 2016

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Recurrence of prostate cancer is suspected when an increase in the prostate-specific antigen level is detected after radical treatment; the recurrence could be local relapse, distant relapse, or both. Differentiation between the two patterns of relapse is critical for choosing the proper treatment strategy. Choline PET/CT could be of help in discriminating patients with local, lymph node, and bone recurrences, thus having an impact on patient management.

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Section: Bone Metastasesmentioning

confidence: 99%

Section: Influence Of Psa On Rate Of Detection By 11 C-choline Pet/ctmentioning

confidence: 99%

¹¹C- or ¹⁸F-Choline PET/CT for Imaging Evaluation of Biochemical Recurrence of Prostate Cancer

et al. 2016

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“…They summarized that PET-CT cannot be recommended as standard diagnostic tool for early relapse or suspicion of minimal persistent disease after surgery (level of evidence 3, see Table 2). Reske et al [32] in a single-centre retrospective study, analysed 49 patients into two groups. The group A included 36 patients with biochemical recurrence after RP and the group B (control group) 13 patients submitted to RP without biochemical relapse.…”

Section: Pet-ctmentioning

confidence: 99%

Comparative analysis of multiparametric magnetic resonance and PET-CT in the management of local recurrence after radical prostatectomy for prostate cancer

Alfarone

Panebianco

Schillaci

et al. 2012

Critical Reviews in Oncology/Hematology

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Purpose\ud \ud Our aim was to assess whether multiparametric magnetic resonance and PET-CT can have a role in detecting local recurrence in patients with biochemical recurrence after radical prostatectomy.\ud \ud Methods\ud \ud We reviewed the recent international literature by carrying out a PUBMED search.\ud \ud Results\ud \ud We critically reviewed 11 recent original studies about the use of PET-CT and 5 recent studies about the use of multiparametric magnetic resonance. PET-CT has not shown significant results in terms of detection rate for local recurrence in patients with low level of PSA. Multiparametric magnetic resonance showed encouraging results to detect local recurrence in patients with low PSA and with small diameter lesions.\ud \ud Conclusions\ud \ud Currently, most important urological societies do not consider multiparametric magnetic resonance and PET-CT in the follow-up of patients with suspected local recurrence after radical prostatectomy. We can assert that multiparametric magnetic resonance seems to have excellent results in detecting local recurrence in patients submitted to radical prostatectomy and PSA < 1.5 ng/ml

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“…Many researchers have reported the usefulness of 11 C-choline PET/CT for restaging prostate cancer after RP, especially for detecting distant metastases most commonly to LNs and bones (2,3). However, only limited data on the utility of 11 Ccholine PET/CT regarding the detection of local recurrence after RP are available in the literature (4,5). Conversely, the combination of T2-weighted imaging and dynamic contrast-enhanced (DCE) MR imaging with endorectal coil has been shown to have an 84%-97% sensitivity and 74%-89% specificity for detecting local recurrence in the prostatectomy bed (6)(7)(8).…”

mentioning

confidence: 99%

Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of ¹¹C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil

et al. 2014

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The aim of this study was to compare 11 C-choline PET/CT with pelvic multiparametric MR imaging for detection of recurrent prostate carcinoma in patients with suspected recurrence after radical prostatectomy and to identify an optimal imaging method to restage these patients. Methods: This was a retrospective, single-institution study of 115 prostatectomy patients with suspected tumor recurrence who underwent both 11 C-choline PET/CT and multiparametric MR imaging with endorectal coil. The reference standard included histopathology, treatment change, and imaging follow-up for determination of locally recurrent tumor, lymph node (LN) metastases, and skeletal metastases. Two nuclear medicine and 2 genitourinary radiologists independently and in a masked manner reviewed PET/ CT and multiparametric MR imaging, respectively. The reviewers assessed for local recurrence in the prostatectomy bed as well as LN and bone metastases, rating their diagnostic confidence with a 5-point scoring system for each location. Receiver-operatingcharacteristic analysis was used to compare the 2 modalities. Results: The standard of reference (either positive or negative) for the diagnosis of local recurrence and pelvic LN and bone metastases was met in 87, 70, and 95 patients, respectively. Documented local recurrence and pelvic LN and bone metastases was present in 61 of 87 (70.1%), 50 of 70 (71.4%), and 16 of 95 (16.8%) patients, respectively. Patient-based area under the receiver-operatingcharacteristic curves of multiparametric MR imaging versus PET/ CT for the diagnosis of local recurrence and pelvic LN and bone metastases were 0.909 versus 0.761 (P 5 0.0079), 0.812 versus 0.952 (P 5 0.0064), and 0.927 versus 0.898 (P 5 0.69), respectively. Among 61 patients with local recurrence, 32 patients (52.4%) were correctly diagnosed as having local recurrence by both multiparametric MR imaging and PET/CT, 22 (36.1%) were correctly diagnosed by multiparametric MR imaging only, 6 (9.8%) could not be diagnosed by either modality, and 1 (1.6%) was correctly diagnosed by PET/CT only. The patient-based sensitivity, specificity, and accuracy of multiparametric MR imaging for diagnosing local recurrence were 88.5% (54/61), 84.6% (22/26), and 87.4% (76/87) whereas those of PET/CT for detecting body LN or bone metastases were 92.3% (72/78), 100% (18/18), and 93.8% (90/96), respectively. Conclusion: Multiparametric MR imaging with endorectal coil is superior for the detection of local recurrence, PET/CT is superior for pelvic LN metastasis, and both were equally excellent for pelvic bone metastasis. 11 C-choline PET/CT and pelvic multiparametric MR imaging are complementary for restaging prostatectomy patients with suspected recurrent disease.

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[11C]choline PET/CT imaging in occult local relapse of prostate cancer after radical prostatectomy

Abstract: Focally increased [(11)C]choline uptake in the prostatic bed reliably predicted local low volume occult relapsing prostate adenocarcinoma after radical prostatectomy and identified 71% of patients with a favourable biochemical response to local radiotherapy.

Cited by 157 publications

References 30 publications

¹¹C- or ¹⁸F-Choline PET/CT for Imaging Evaluation of Biochemical Recurrence of Prostate Cancer

¹¹C- or ¹⁸F-Choline PET/CT for Imaging Evaluation of Biochemical Recurrence of Prostate Cancer

Comparative analysis of multiparametric magnetic resonance and PET-CT in the management of local recurrence after radical prostatectomy for prostate cancer

Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of ¹¹C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil

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[11C]choline PET/CT imaging in occult local relapse of prostate cancer after radical prostatectomy

Abstract: Focally increased [(11)C]choline uptake in the prostatic bed reliably predicted local low volume occult relapsing prostate adenocarcinoma after radical prostatectomy and identified 71% of patients with a favourable biochemical response to local radiotherapy.

Cited by 157 publications

References 30 publications

11C- or 18F-Choline PET/CT for Imaging Evaluation of Biochemical Recurrence of Prostate Cancer

11C- or 18F-Choline PET/CT for Imaging Evaluation of Biochemical Recurrence of Prostate Cancer

Comparative analysis of multiparametric magnetic resonance and PET-CT in the management of local recurrence after radical prostatectomy for prostate cancer

Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of 11C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil

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¹¹C- or ¹⁸F-Choline PET/CT for Imaging Evaluation of Biochemical Recurrence of Prostate Cancer

¹¹C- or ¹⁸F-Choline PET/CT for Imaging Evaluation of Biochemical Recurrence of Prostate Cancer

Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of ¹¹C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil