[11C]Carbon monoxide in the palladium-mediated synthesis of 11C-labelled ketones

Lidström, Pelle; Kihlberg, Tor; Långström, Bengt

doi:10.1039/a703062b

Cited by 64 publications

(75 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Trichloromethyl chloroformate (diphosgene) 11 was one of the first substitutes affording certain unlabeled isocyanates in excellent yields. Carbon dioxide has also been used in methods that avoid the preparation of phosgene, for example, [ 11 19,20 and selenium-mediated syntheses of 11 C-carbamoyl compounds. 21 But still, it has been proven to be difficult to trap [ 11 C]CO in a reaction mixture using conventional methods, i.e.…”

Section: Resultsmentioning

confidence: 99%

“…by leading the radioactive precursor with a carrier gas into a solution. 22 Because of the low solubility of [ 11 C]CO, it has been necessary to develop a specific gas handling system for the preconcentration of [ 11 C]CO 2 , the conversion to and recirculation of [ 11 C]CO. 19,21 In this study, phosphinimines (iminophosphoranes) 23 were used for the synthesis of 11 C-labeled ureas, to circumvent the mentioned disadvantages of the described methods (i.e. the relatively large number of reaction steps, the use of catalysts or reagents such as Pd, Se or Sn reagents, and specific automation).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

One‐pot synthesis of [¹¹C]ureas via triphenylphosphinimines

Tilburg

Windhorst

Mey

et al. 2006

Labelled Comp Radiopharmac

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

One‐pot synthesis of [¹¹C]ureas via triphenylphosphinimines

Tilburg

Windhorst

Mey

et al. 2006

Labelled Comp Radiopharmac

View full text Add to dashboard Cite

show abstract

“…[110] Abgelöst wurde dieses Verfahren durch die Einführung von Hochdruckreaktionssystemen (HPLC-Mikroautoklaven) [36,37] [117] oder 1,2,2,6,6-Pentamethylpiperidin [118] Rhodiumvermittelte Carbonylierungen [122][123][124] sind eine weitere Möglichkeit zur Einführung von [ 11 C]CO in organische Moleküle.…”

Section: Bei Den Stille-kreuzkupplungen Mit [unclassified

Synthese von ¹¹C‐, ¹⁸F‐, ¹⁵O‐ und ¹³N‐Radiotracern für die Positronenemissionstomographie

et al. 2008

View full text Add to dashboard Cite

Die Positronenemissionstomographie (PET) ist eine leistungsfähige Bildgebungsmethode, die zur Untersuchung und Visualisierung der menschlichen Physiologie eingesetzt wird. Das Funktionsprinzip der PET beruht auf der Detektion positronenemittierender Radiopharmazeutika. Aus PET‐Experimenten können direkte Informationen über Stoffwechselvorgänge, Rezeptor‐Enzym‐Funktionen und biochemische Mechanismen im lebenden Gewebe erhalten werden. Anders als die Magnetresonanztomographie (MRT) und die Computertomographie (CT), die in erster Linie anatomische Bilder liefern, kann die PET chemische Veränderungen messen, die bereits vor dem Auftreten anatomischer Krankheitszeichen auftreten. Die PET ist dabei, sich als eine revolutionäre Methode für die Diagnostik von Körperfunktionen zu etablieren, die die Anwendung individueller, auf den Patienten zugeschnittener Behandlungsmethoden ermöglicht. Allerdings ist die Entwicklung von Synthesestrategien für neuartige positronenemittierende Moleküle nicht trivial. In diesem Aufsatz diskutieren wir die entscheidenden Aspekte bei der Synthese von PET‐Radiotracern mit den kurzlebigen Positronenemittern 11C, 18F, 15O und 13N. Der Schwerpunkt liegt auf den jüngsten Fortschritten bei der Entwicklung von Radiomarkierungsstrategien. Wir hoffen, dass dieser Aufsatz das Interesse von Synthesechemikern auch außerhalb der Radiochemie finden wird und die Bedeutung der PET in der molekularen Bildgebung sowie den Bedarf an neuen, innovativen chemischen Strategien für verbesserte Radiomarkierungstechniken aufzeigt.

show abstract

“…CO), normally obtained from [ 11 C]carbon dioxide, is increasingly used for the synthesis of labelled carbonyl compounds such as aldehydes, ketones[37], amides, carboxylic acids and esters[25]. Other useful precursors include hydrogen [11 C]cyanide (H[ 11 C]CN) [38], [ 11 C]phosgene ([ 11 C]COCl 2 ) [39] and [ 11 C]diazomethane ([ 11 C]CH 3 N 2 ) [40], usually obtained on-line from [ 11 C]methane.…”

mentioning

confidence: 99%

Radiolabelled Molecules for Imaging the Translocator Protein (18 kDa) Using Positron Emission Tomography

Dollé¹,

Luus²,

Reynolds³

et al. 2009

CMC

122

103

View full text Add to dashboard Cite

The translocator protein (18 kDa) (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR), was originally identified as an alternate binding site for the central benzodiazepine receptor (CBR) ligand, diazepam, in the periphery, but has now been distinguished as a novel site. The TSPO is ubiquitously expressed in peripheral tissues but only minimally in the healthy brain and increased levels of TSPO expression have been noted in neuroinflammatory conditions such as Alzheimer's disease, Parkinson's disease and stroke. This increase in TSPO expression has been reported to coincide with the process of microglial activation, whereby the brain's intrinsic immune system becomes active. Therefore, by using recently developed high affinity, selective TSPO ligands in conjunction with functional imaging modalities such as positron emission tomography (PET), it becomes possible to study the process of microglial activation in the living brain. A number of high affinity ligands, the majority of which are C,N-substituted acetamide derivatives, have been successfully radiolabelled and used in in vivo studies of the TSPO and the process of microglial activation. This review highlights recent achievements (up to December 2008) in the field of functional imaging of the TSPO as well as the radiosyntheses involved in such studies.

show abstract

[11C]Carbon monoxide in the palladium-mediated synthesis of 11C-labelled ketones

Cited by 64 publications

References 15 publications

One‐pot synthesis of [¹¹C]ureas via triphenylphosphinimines

One‐pot synthesis of [¹¹C]ureas via triphenylphosphinimines

Synthese von ¹¹C‐, ¹⁸F‐, ¹⁵O‐ und ¹³N‐Radiotracern für die Positronenemissionstomographie

Radiolabelled Molecules for Imaging the Translocator Protein (18 kDa) Using Positron Emission Tomography

Contact Info

Product

Resources

About

[11C]Carbon monoxide in the palladium-mediated synthesis of 11C-labelled ketones

Cited by 64 publications

References 15 publications

One‐pot synthesis of [11C]ureas via triphenylphosphinimines

One‐pot synthesis of [11C]ureas via triphenylphosphinimines

Synthese von 11C‐, 18F‐, 15O‐ und 13N‐Radiotracern für die Positronenemissionstomographie

Radiolabelled Molecules for Imaging the Translocator Protein (18 kDa) Using Positron Emission Tomography

Contact Info

Product

Resources

About

One‐pot synthesis of [¹¹C]ureas via triphenylphosphinimines

One‐pot synthesis of [¹¹C]ureas via triphenylphosphinimines

Synthese von ¹¹C‐, ¹⁸F‐, ¹⁵O‐ und ¹³N‐Radiotracern für die Positronenemissionstomographie