1187 Molecular Mechanism of Synergistic Anti-tumor Activity by the Combination of Natural Compounds Green Tea (-)Epigallocathetin-3-gallate (EGCG) and Resveratrol for Potential Chemoprevention in Head and Neck Cancer (HNC)

Shin, Dong-Ho; Amin, Aarshati; Wang, D.; Rahman, Mohammad Aminur; Nannapaneni, Sreenivas; Khuri, Fadlo R.; Chen, Z.G.

doi:10.1016/s0959-8049(12)71781-1

Cited by 4 publications

(3 citation statements)

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“…EGCG antagonizes toxicity induced by anti-cancer chemotherapeutic agents, and sensitizes chemo-resistant cancer cells. It also exerts synergistic effects with anti-cancer agents in various cancer cells, such as cisplatin, oxaliplatin, temozolomide, resveratrol, doxorubicin, vardenafil, curcumin, erlotinib [122][123][124][125][126][127][128][129]. EGCG can enhance the sensitivity of cisplatin through copper transporter 1 (CTR1) up-regulation, which results in the accumulation of cellular cisplatin and cisplatin-DNA adducts in human ovarian cancer SKOV3 and OVCAR3 cells, and the combination of EGCG and cisplatin suppresses tumor growth in OVCAR3 xenograft mice [122].…”

Section: Epigallocatechin Gallate (Egcg)mentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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Section: Epigallocatechin Gallate (Egcg)mentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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“…It is of industrial interest to develop the products that contain several bioactive components in the market, thus providing multiple health benefits. , Moreover, the synergistic effect was reported in the combination of different bioactive components. − It is thus required to develop the carriers that can simultaneously encapsulate and protect different bioactive components. β-Lactoglobulin, which contains a primary binding site in the internal cavity and multiple external potential binding sites, was reported to bind α-tocopherol, resveratrol, and folic acid simultaneously to form protein-triligand complexes .…”

Section: Introductionmentioning

confidence: 99%

Formation of a Multiligand Complex of Bovine Serum Albumin with Retinol, Resveratrol, and (−)-Epigallocatechin-3-gallate for the Protection of Bioactive Components

Cheng

Chen

et al. 2017

J. Agric. Food Chem.

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Clarification of the interaction mechanisms between proteins and bioactive components is important to develop effective carriers for encapsulation and protection of bioactive components. Bovine serum albumin (BSA), a globular protein in serum and milk, contains multiple sites to bind a variety of low-molecular-weight molecules, forming protein-monoligand complexes. In this study, the interactions of BSA with retinol, resveratrol, and/or (-)-epigallocatechin-3-gallate (EGCG) were investigated by using fluorescence, circular dichroism, and molecular docking techniques. BSA-triligand complexes were successfully formed when added in the sequence of retinol, resveratrol, and EGCG. The stability of these bioactive components was improved in the complexes relative to free ones. The complexes provided a better protective effect on retinol and resveratrol than did BSA-monoligand complexes, in which the presence of EGCG played an important role.

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“…Combination therapy significantly improves effectiveness compared to the traditional single-drug, single-target treatment paradigm. It has been found that EGCG is able to sensitize chemotherapy-resistant cancer cells, and it can act synergistically with various anticancer drugs in cancer treatment, such as cisplatin, oxaliplatin, temozolomide, resveratrol, doxorubicin, vardenafil, curcumin, erlotinib, and others [ 278 , 279 , 280 , 281 , 282 , 283 , 284 , 285 ]. In human ovarian cancer SKOV3 and OVCAR3 cells, EGCG enhances sensitivity to cisplatin by upregulating copper transporter protein 1 (CTR1), leading to the accumulation of intracellular cisplatin and cisplatin-DNA adducts, and the combination of EGCG and cisplatin inhibits tumor growth in OVCAR3 xenograft mice [ 278 ].…”

Section: Synergistic Effects and Combination Therapiesmentioning

confidence: 99%

Research Progress of Plant-Derived Natural Products against Drug-Resistant Cancer

Liu,

Wang,

Xia

et al. 2024

Nutrients

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As one of the malignant diseases globally, cancer seriously endangers human physical and mental health because of its high morbidity and mortality. Conventional cancer treatment strategies, such as surgical resection and chemoradiotherapy, are effective at the early stage of cancer but have limited efficacy for advanced cancer. Along with cancer progress and treatment, resistance develops gradually within the population of tumor cells. As a consequence, drug resistance become the major cause that leads to disease progression and poor clinical prognosis in some patients. The mechanisms of cancer drug resistance are quite complex and involve various molecular and cellular mechanisms. Therefore, exploring the mechanisms and finding specific targets are becoming imperative to overcome drug resistance. In recent years, plant-derived natural products have been evaluated as potential therapeutic candidates against cancer with drug resistance due to low side effects and high anticancer efficacy. A growing number of studies have shown that natural products can achieve superior antitumor effects through multiple signaling pathways. The mechanisms include regulation of multiple drug resistance (MDR)-related genes, inhibition of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway, induction of autophagy, and blockade of the cell cycle. This paper reviews the molecular and cellular mechanisms of cancer drug resistance, as well as the therapeutic effects and mechanisms of plant-derived natural products against cancer drug resistance. It provides references for developing therapeutic medication for drug-resistant cancer treatment with high efficacy and low side effects.

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1187 Molecular Mechanism of Synergistic Anti-tumor Activity by the Combination of Natural Compounds Green Tea (-)Epigallocathetin-3-gallate (EGCG) and Resveratrol for Potential Chemoprevention in Head and Neck Cancer (HNC)

Cited by 4 publications

References 0 publications

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Formation of a Multiligand Complex of Bovine Serum Albumin with Retinol, Resveratrol, and (−)-Epigallocatechin-3-gallate for the Protection of Bioactive Components

Research Progress of Plant-Derived Natural Products against Drug-Resistant Cancer

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