1177 Interleukin-28b Predicts SVR in Latin American Hepatitis C Genotype 1 Patients Treated With Peg Ifn and Ribavirin

Ridruejo, Ezequiel; Solano, Antonio Manzano; Delettieres, Dreanina; Martínez, A.; Marciano, Sebastián; Mandó, Oscar G.; Galdame, Omar; Gadano, Adrián; Silva, M.O.; Adrover, Raúl; Cocozzella, Daniel

doi:10.1016/s0168-8278(11)61179-3

Cited by 3 publications

(3 citation statements)

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“…A study carried out in a Spanish cohort showed similar results for rs12979860 allele C frequency [8]. Our results are consistent with a previous report [7] in Argentine patients of European ancestry, and to our knowledge, the first report with such a genetic analysis on a single Latin-American cohort in untreated HCV-infected patients. Furthermore, we show for the first time an association between hepatic inflammatory activity in a single Argentine cohort of untreated chronically HCV-infected patients and single nucleotide polymorphisms located close to IFN-λ3.…”

Section: Discussionsupporting

confidence: 92%

“…As previously mentioned, host genetics plays an important role in the outcome of antiviral therapy [3] [4] [5] [6] [7]. We found that C and T were the most represented alleles for rs12979860 and rs8099917, respectively.…”

Section: Discussionsupporting

confidence: 57%

“…The degree of liver damage, measured by liver biopsies or through a variety of non-invasive tests, together with the determination of HCV genotype, is used to guide therapeutic decisions and management of the disease, to determine the most appropriate approach for each patient. In order to contribute to decisions related to the course of treatment, several groups working in Genome Wide Association Studies identified Single Nucleotide Polymorphisms (SNPs) associated to the outcome of antiviral therapy in chronic HCV patients [3] [4] [5] [6] [7]. Among them the SNPs rs12979860 and rs8099917…”

Section: Introductionmentioning

confidence: 99%

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IL28B SNPs rs12979860 and rs8099917 Are Associated with Inflammatory Response in Argentine Chronic HCV Patients

Machicote¹,

Flichmann²,

Arana³

et al. 2018

IJCM

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Background: Hepatitis C virus (HCV) is a major cause of chronic liver disease, including cirrhosis and liver cancer. The aim of our study was to determine whether IL28B single nucleotide polymorphisms (SNPs) rs12979860 and rs8099917 can be considered a prognostic host factor in untreated chronic HCV patients. Methods: We set up a real-time Allele Specific PCR amplification to determine the allele present in each polymorphic site, and statistically grouped and compared this result with clinical data. Results: We determined rs12979860 and rs8099917 genotype and allele frequencies in a single cohort of untreated chronically HCV-infected patients. We found significant associations between higher inflammatory activity, measured as ALT levels or METAVIR scores and rs12979860 CC (P = 0.0013 and P = 0.0033, respectively) and rs8099917 TT (P = 0.0005 and P = 0.0264, respectively) genotypes. Interestingly, considering both genotypes together, we also found association with ALT levels (P = 0.0003; OR = 5.125) or METAVIR scores (P = 0.0038; OR = 5.179), suggesting and additive effect on liver inflammation in these patients. Conclusion: we show association between hepatic inflammatory activity in a single Argentinean untreated chronically HCV cohort and SNPs located in the interferon lambda gene region. The studied polymorphisms, together with further innate and adaptive immune responses, clearly play a role in modulating the HCV infected patients outcome, contributing to hepatic inflammation and possible fibrosis/cirrhosis.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

IL28B SNPs rs12979860 and rs8099917 Are Associated with Inflammatory Response in Argentine Chronic HCV Patients

Machicote¹,

Flichmann²,

Arana³

et al. 2018

IJCM

View full text Add to dashboard Cite

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Molecular Evolution of Hepatitis C Virus: From Epidemiology to Antiviral Therapy (Current Research in Latin America)

Echeverría

Moreno

Cristina

2017

Human Virology in Latin America

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Test of IL28B Polymorphisms in Chronic Hepatitis C Patients Treated with PegIFN and Ribavirin Depends on HCV Genotypes: Results from a Meta-Analysis

et al. 2012

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BackgroundMany studies have been published on the association between single nucleotide polymorphisms (SNP) near the IL28B gene and response to the combined treatments of pegylated-interferon (PegIFN) and ribavirin (RBV) in chronic HCV-infected patients, but without identical conclusions. The aim of this study was to assess impact of the IL28B polymorphisms on the effect of HCV standard treatment using meta-analysis based method.MethodsAssociation studies between polymorphisms of rs12979860 or rs8099917 and response to PegIFN/RBV treatment in chronic HCV patients were retrieved from PubMed. Data of qualified studies on sustained virological response (SVR) in different genotypes were extracted and analyzed using meta-analysis method in Stata 10 software.ResultsThirty-four papers, containing 46 independent studies, were included in the analysis. In the HCV G1/4 patients without treatment history, individuals carrying rs12979860 CC genotype were more likely to achieve SVR (OR 3.97, 95%CI 3.29–4.80) compared to those carrying CT/TT genotypes. Similar results were observed in the HCV G1/4 patients with unsuccessful or unknown treatment history (OR 3.76, 95%CI 2.67–5.28) or in the patients co-infected with human immunodeficiency virus (OR 5.20, 95%CI 3.04–8.90). However, associations could not be observed in HCV G2/3 patients. For rs8099917, similar results were obtained for genotype TT compared to genotypes TG/GG, indicating that TT genotype was significantly associated with better treatment response in patients infected with genotype 1 or 4 HCV, but not genotype 2 or 3 HCV.ConclusionPolymorphisms of rs12979860 and rs8099917 near IL28B only associate with the treatment response to PegIFN/RBV in patients infected with HCV genotype 1 or 4 but not with genotype 2 or 3, irrespective of the previous treatment history or HIV co-infected status. Therefore, identification of IL28B genotypes is necessary only in patients infected with relatively difficult-to-treat genotype 1 or 4 HCV.

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1177 Interleukin-28b Predicts SVR in Latin American Hepatitis C Genotype 1 Patients Treated With Peg Ifn and Ribavirin

Cited by 3 publications

References 0 publications

IL28B SNPs rs12979860 and rs8099917 Are Associated with Inflammatory Response in Argentine Chronic HCV Patients

IL28B SNPs rs12979860 and rs8099917 Are Associated with Inflammatory Response in Argentine Chronic HCV Patients

Molecular Evolution of Hepatitis C Virus: From Epidemiology to Antiviral Therapy (Current Research in Latin America)

Test of IL28B Polymorphisms in Chronic Hepatitis C Patients Treated with PegIFN and Ribavirin Depends on HCV Genotypes: Results from a Meta-Analysis

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