117. Can 99Tcm-HMPAO leukocyte scintigraphy distinguish between Crohn??s disease and ulcerative colitis?

Li, D. J.; Freeman, Alan; Miles, Kenneth; Wraight, E. P.

doi:10.1097/00006231-199304000-00119

Cited by 2 publications

(3 citation statements)

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“…In Crohn's disease abnormal activity is found to affect the small bowel and right iliac fossa region with irregular uptake (variable intensity of uptake within an affected area of bowel) and is more likely to show the presence of skip lesions. In contrast, ulcerative colitis is more likely to involve the rectum and the left side of colon [29,30]. In the study by Li et al the accuracy of white cell scanning in diagnosing Crohn's disease was higher than that of radiology (98 vs 86 %) [29].…”

Section: Radio-isotope Studiesmentioning

confidence: 99%

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Paediatric Crohn's disease: a radiological review

Ali

Carty

2000

European Radiology

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Paediatric Crohn's disease can be a serious and complex condition which is not always easy to diagnose if it presents in an atypical manner. Although the pathological processes are the same in adults and children, the clinical presentation and disease distribution can be different in children. The impact of the disease can also be much more significant in a growing and developing child than in an adult. Numerous investigations are available to establish the diagnosis, define the complications and to demonstrate the extra-intestinal manifestations. Close cooperation is required between the clinician and radiologist when investigating a child suspected of having Crohn's disease or its symptoms to minimise the radiation dose and the psychological and physical trauma. We review the clinical and radiological aspects of Crohn's disease and discuss the imaging modalities available in diagnosing Crohn's disease and its complications and suggest an investigation pathway as used in our institution.

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Section: Radio-isotope Studiesmentioning

confidence: 99%

“…In contrast, ulcerative colitis is more likely to involve the rectum and the left side of colon [29,30]. In the study by Li et al the accuracy of white cell scanning in diagnosing Crohn's disease was higher than that of radiology (98 vs 86 %) [29].…”

Section: Radio-isotope Studiesmentioning

confidence: 99%

Paediatric Crohn's disease: a radiological review

Ali

Carty

2000

European Radiology

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“…99m Tc-HMPAO (hexamethyl propylene amine oxime) leucocyte scintigraphy has been widely advocated as an investigative technique for patients with suspected inflammatory bowel disease 1. It can reveal the presence and distribution of inflammation in the gastrointestinal tract, and it has been reported to compare well with conventional techniques such as barium contrast radiology and colonoscopy 1-19. Scintigraphy has several clear advantages: it is associated with much lower levels of radiation exposure than contrast radiology20; unlike colonoscopy, it is non-invasive and so intravenous sedation and general anaesthesia are not required21; finally, it avoids the troublesome and unpleasant process of laxative bowel preparation necessary for colonoscopy.…”

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confidence: 99%

^99mTc-HMPAO leucocyte scintigraphy fails to detect Crohn's disease in the proximal gastrointestinal tract

2001

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Objective-To investigate the use of 99m Tc-HMPAO (hexamethyl propylene amine oxime) leucocyte scintigraphy as a noninvasive screening test for inflammatory bowel disease. Patients-10 children with suspected Crohn's disease, in whom routine investigation using barium contrast radiology, upper gastrointestinal endoscopy, colonoscopy, and mucosal biopsies had identified severe gastroduodenal and/or jejunal involvement. Design99mTc-HMPAO leucocyte scintigraphic studies performed in each of these cases were assessed by a radiologist who was blinded to the disease distribution. Results-In nine cases there was no scintigraphic evidence of inflammation in the proximal gastrointestinal tract. The 10th child had both gastroduodenal and jejunal involvement, but scintigraphy only revealed faint jejunal positivity. Conclusions- 99m

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117. Can 99Tcm-HMPAO leukocyte scintigraphy distinguish between Crohn??s disease and ulcerative colitis?

Cited by 2 publications

References 0 publications

Paediatric Crohn's disease: a radiological review

Paediatric Crohn's disease: a radiological review

^99mTc-HMPAO leucocyte scintigraphy fails to detect Crohn's disease in the proximal gastrointestinal tract

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