1168: Long-Term Quality of Life in Survivors of Pediatric Out-of-Hospital Cardiac Arrest

Hickson, Meredith; Winters, Madeline; Thomas, Nina H.; Gardner, Monique M.; Kirschen, Matthew; Berg, Robert; Pinto, Neethi; Topjian, Alexis

doi:10.1097/01.ccm.0000730560.22662.bc

Cited by 4 publications

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“…Mean age ranged from 1.5 to 6.4 years. Three studies were conducted in the United States of America [ 22 , 23 , 24 ], two were conducted in the Netherlands [ 25 , 26 ], one in Finland [ 27 ], and one in Taiwan [ 28 ]. Two studies were prospective cohort studies, and five were retrospective cohort studies.…”

Section: Resultsmentioning

confidence: 99%

“…Four articles reported the HRQoL outcomes of pediatric OHCA patients. One [ 26 ] study was comparative, comparing the HRQoL of the long-term survivors of pediatric OHCA to the general population, while the other three [ 23 , 24 , 27 ] studies were non-comparative. The summary of the four studies is presented in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Hickson et al [ 24 ] utilized the PedsQL [ 29 ] to measure HRQoL outcomes of pediatric OHCA patients on a scale of 0–100, with a higher score indicating better HRQoL. PedsQL scores for the studied population were reported as 85 (95% CI = 69, 93).…”

Section: Resultsmentioning

confidence: 99%

“…Only one paper reported outcomes on family and caregiver burden in the longer term. Hickson et al [ 24 ] employed the PedsQL family impact module (PedsQL–FIM [ 30 ]), a specific module of the PedsQL, in measuring the impact of pediatric acute and chronic health conditions on parents and the family (i.e., caregivers). PedsQL–FIM scores were 76 (95% CI = 63, 95).…”

Section: Resultsmentioning

confidence: 99%

“…While Hickson et al [ 24 ] reported a PedsQL–FIM score of 76 (a scale of 0–100, with higher scores indicating a better HRQoL), Hickson et al utilized only a small pilot sample size of 17, which Bohm et al [ 45 ] cautioned against. In addition, both Meert et al [ 46 ] and Bohm et al [ 45 ] found that poor neurological outcomes are related to increased caregiver burden.…”

Section: Discussionmentioning

confidence: 99%

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Long-Term Outcomes after Non-Traumatic Out-of-Hospital Cardiac Arrest in Pediatric Patients: A Systematic Review

Caleb

et al. 2022

JCM

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Long-term outcomes after non-traumatic pediatric out-of-hospital cardiac arrest (OHCA) are not well understood. This systematic review aimed to summarize long-term outcomes (1 year and beyond), including overall survival, survival with favorable neurological outcomes, and health-related quality of life (HRQoL) outcomes) amongst pediatric OHCA patients who survived to discharge. Embase, Medline, and The Cochrane Library were searched from inception to October 6, 2021. Studies were included if they reported outcomes at 1 year or beyond after pediatric OHCA. Data abstraction and quality assessment was conducted by three authors independently. Qualitative outcomes were reported systematically. Seven studies were included, and amongst patients that survived to hospital discharge or to 30 days, longer-term survival was at least 95% at 24 months of follow up. A highly variable proportion (range 10–71%) of patients had favorable neurological outcomes at 24 months of follow up. With regard to health-related quality of life outcomes, at a time point distal to 1 year, at least 60% of pediatric non-traumatic OHCA patients were reported to have good outcomes. Our study found that at least 95% of pediatric OHCA patients, who survived to discharge, survived to a time point distal to 1 year. There is a general paucity of data surrounding the pediatric OHCA population.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Long-Term Outcomes after Non-Traumatic Out-of-Hospital Cardiac Arrest in Pediatric Patients: A Systematic Review

Caleb

et al. 2022

JCM

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Decisions Regarding Life or Death in Comatose Children After Out-of-Hospital Cardiac Arrest*

Hunfeld,

Buysse

2024

Pediatric Critical Care Medicine

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Rapid, selective and homogeneous brain cooling with transnasal flow of ambient air for pediatric resuscitation

Koehler

Reyes

Hopkins

et al. 2023

J Cereb Blood Flow Metab

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Neurologic outcome from out-of-hospital pediatric cardiac arrest remains poor. Although therapeutic hypothermia has been attempted in this patient population, a beneficial effect has yet to be demonstrated, possibly because of the delay in achieving target temperature. To minimize this delay, we developed a simple technique of transnasal cooling. Air at ambient temperature is passed through standard nasal cannula with an open mouth to produce evaporative cooling of the nasal passages. We evaluated efficacy of brain cooling with different airflows in different size piglets. Brain temperature decreased by 3°C within 25 minutes with nasal airflow rates of 16, 32, and 16 L/min in 1.8-, 4-, and 15-kg piglets, respectively, whereas rectal temperature lagged brain temperature. No substantial spatial temperature gradients were seen along the neuroaxis, suggesting that heat transfer is via blood convection. The evaporative cooling did not reduce nasal turbinate blood flow or sagittal sinus oxygenation. The rapid and selective brain cooling indicates a high humidifying capacity of the nasal turbinates is present early in life. Because of its simplicity, portability, and low cost, transnasal cooling potentially could be deployed in the field for early initiation of brain cooling prior to maintenance with standard surface cooling after pediatric cardiac arrest.

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1168: Long-Term Quality of Life in Survivors of Pediatric Out-of-Hospital Cardiac Arrest

Cited by 4 publications

References 0 publications

Long-Term Outcomes after Non-Traumatic Out-of-Hospital Cardiac Arrest in Pediatric Patients: A Systematic Review

Long-Term Outcomes after Non-Traumatic Out-of-Hospital Cardiac Arrest in Pediatric Patients: A Systematic Review

Decisions Regarding Life or Death in Comatose Children After Out-of-Hospital Cardiac Arrest*

Rapid, selective and homogeneous brain cooling with transnasal flow of ambient air for pediatric resuscitation

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