Abstract:Background Soft tissue sarcomas are rare connective tissue malignancies that are highly resistant to traditional systemic therapies. 1 Sarcomas are relatively common in dogs, yet few studies have previously investigated anti-sarcoma immunotherapies in this species. 2,3 In this study, we sought to investigate several small molecule STING (STimulator of INterferon Genes) agonists' dose toxicities and pathway inductions via canonical cytokine responses in canine macrophage and sarcoma lines, as compared to murine… Show more
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