114 Prognostic Value of Human Hepatocyte Growth Factor (Hgf) Serum Levels and Gene Expression in Serum and Liver Tissue in Fulminant Hepatic Failure (Fhf)

Singla, Monika; Singhal, Saurabh; Medhi, Subhash; Polipalli, Sunil Kumar; P, Kar

doi:10.1016/s0168-8278(09)60116-1

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We recently showed that blood PMN are hyperactivated during AH, as they produce high amounts of reactive oxygen species (ROS), proinflammatory cytokines and chemokines maintaining liver inflammation (Taieb et al, 2000),PMN infiltration is also a factor of good prognosis, as corticosteroid therapy ,the reference treatment of severe acute alcoholic hepatitis (AH) is particularly effective in patients with marked neutrophilia or liver PMN infiltration. Singla et al( 2010), postulated that activated PMN were a source of HGF in AH, and could therefore participate in tissue repair. Blood PMN from cirrhotic patients with and without AH were isolated and compared for their capacity to secrete HGF .…”

Section: Discussionmentioning

confidence: 99%

Significance of apoptotic markers Bcl-2, CD4+ T cells, hepatocyte growth factor and metalloproteinase -9 in infected patients with HCV

Youness¹

2013

J. App. Pharm. Sci.

View full text Add to dashboard Cite

To examine the possible involvement of human B-cll leukemia /lymphoma 2(Bcl2) , CD 4+ cells , hepatocyte growth factor (HGF) and metalloproteinase -9 ( MMP-9), in the development of liver diseases caused by HCV infection, serum activities of these biomarkers were demonstrated by quantitave detemination of Enzyme Linked Immunosorbant Assay(ELISA) . Two groups of subjects (60 for each) were examined in this study: healthy control and patients with chronic hepatitis C(HCV) The results showed significant decrease in Bcl-2 (P≤ 0.0001) , and CD 4+ (P≤0.001) , while significant increase in HGF and MMP-9(P≤0.05). These findings imply an influence of these biomarkers by the existence of virus that might influence the following progression of liver disease, and a distinction between the pathological mechanisms of HCV. Since the serum MMP-9 activity were significantly varied between each stage of liver disease, an individual profile of these parameters might serve as an easy accessing serum marker to monitor the progression of liver disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Significance of apoptotic markers Bcl-2, CD4+ T cells, hepatocyte growth factor and metalloproteinase -9 in infected patients with HCV

Youness¹

2013

J. App. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

114 Prognostic Value of Human Hepatocyte Growth Factor (Hgf) Serum Levels and Gene Expression in Serum and Liver Tissue in Fulminant Hepatic Failure (Fhf)

Cited by 1 publication

References 0 publications

Significance of apoptotic markers Bcl-2, CD4+ T cells, hepatocyte growth factor and metalloproteinase -9 in infected patients with HCV

Significance of apoptotic markers Bcl-2, CD4+ T cells, hepatocyte growth factor and metalloproteinase -9 in infected patients with HCV

Contact Info

Product

Resources

About