1132: Salvage Cryosurgical Ablation of the Prostate (TCAP) for Patients Failing Radiation: Efficacy and Tolerability

Katz, Aaron E.; Prepelica, Kristofer; McKiernan, James M.; Olsson, Carl A.; Benson, Mitchell C.

doi:10.1016/s0022-5347(18)33357-3

Cited by 4 publications

(6 citation statements)

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“…Current published cryotherapy series report BCR-free survival rates ranging from 34% to 98% [29][30][31][32][33][34][35]. Several institutions are now studying the use of cryotherapy in the salvage setting.…”

Section: Resultsmentioning

confidence: 99%

Locally ablative therapies for primary radiation failures: A review and critical assessment of the efficacy

Huang

Lee²,

Eastham

2007

Curr Urol Rep

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A significant number of men with prostate cancer will experience biochemical failure following treatment with primary radiation therapy. For patients with biopsy-proven recurrent cancer confined to the prostate, local salvage therapy may be a potentially curative treatment option. Most men, however, do not undergo local salvage therapy owing to difficulties in diagnosis as well as concerns over treatment-related complications in the salvage setting. Recently, improvements in technique and technology have substantially reduced the morbidity associated with locally ablative therapies, resulting in an increased interest in the use of minimally invasive therapies such as brachytherapy, cryotherapy, and high-intensity focused ultrasound in the salvage setting. Although these treatments are well tolerated, concerns remain over incomplete and inadequate treatment with locally ablative therapies. Future studies are required to appropriately select candidates for salvage ablative therapies and to determine the long-term oncologic efficacy of these treatments.

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Section: Resultsmentioning

confidence: 99%

Locally ablative therapies for primary radiation failures: A review and critical assessment of the efficacy

Huang

Lee²,

Eastham

2007

Curr Urol Rep

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“…Because there is no consensus on the definition of BCR following cryotherapy, it is difficult to compare results from the various studies. Current published cryotherapy series report BCRfree survival rates ranging from 34% to 98% [29][30][31][32][33][34][35]. The longest series (Bahn et al [31]) reports a BCR-free survival rate of 59% at 7 years.…”

Section: Resultsmentioning

confidence: 99%

“…Rectourethral fistulas, the most serious complication following cryotherapy, are relatively uncommon (0% to 4%). Currently reported long-term complications following salvage cryotherapy include erectile dysfunction (77% to 100%), rectal pain (10% to 40%), urinary incontinence (4% to 20%), urinary retention (0% to 7%), and urethral sloughing (0% to 5%) [29][30][31][32]35]. In the Chin et al series [30], the strongest predictors for complications included bulky disease (fistula formation) and prior instrumentation or TURP.…”

Section: Complicationsmentioning

confidence: 99%

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Locally ablative therapies for primary radiation failures: A review and critical assessment of the efficacy

Huang¹,

Lee²,

Eastham³

2007

Curr prostate rep

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A significant number of men with prostate cancer will experience biochemical failure following treatment with primary radiation therapy. For patients with biopsyproven recurrent cancer confined to the prostate, local salvage therapy may be a potentially curative treatment option. Most men, however, do not undergo local salvage therapy owing to difficulties in diagnosis as well as concerns over treatment-related complications in the salvage setting. Recently, improvements in technique and technology have substantially reduced the morbidity associated with local ablative therapies, resulting in an increased interest in the use of minimally invasive therapies such as brachytherapy, cryotherapy, and high-intensity focused ultrasound in the salvage setting. Although these treatments are well tolerated, concerns remain over incomplete and inadequate treatment with local ablative therapies. Future studies are required to appropriately select candidates for salvage ablative therapies and to determine the long-term oncologic efficacy of these treatments.

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“…Fully published follow-up results often combine second-and third-generation cryoablation [39], or do not differentiate in outcome results between primary and salvage cryoablation [33], or data are available in abstract form only [40,41]. Nevertheless, it is noteworthy that Katz et al [40] achieved an ASTRO biochemical recurrence-free survival rate at a median 37 months follow-up of 73.3% and 90.2% of patients had a PSA nadir of less than half their presalvage therapy PSA level [40]. Lam et al [41] treated 22 patients after failed external-beam radiotherapy or brachytherapy.…”

Section: Third-generation Salvage Cryoablationmentioning

confidence: 99%

Energy-based ablative therapy of prostate cancer: high-intensity focused ultrasound and cryoablation

Marberger

2007

Current Opinion in Urology

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These minimally invasive techniques are not magic bullets, and patients must be informed accordingly. Focal ablation of the prostate segment with the index cancer would minimize morbidity and therefore appears highly appealing. Its success depends on correct localization of the lesion. Until this is achieved with sufficient reliability by appropriate biopsy or imaging techniques it remains strictly experimental.

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1132: Salvage Cryosurgical Ablation of the Prostate (TCAP) for Patients Failing Radiation: Efficacy and Tolerability

Cited by 4 publications

References 0 publications

Locally ablative therapies for primary radiation failures: A review and critical assessment of the efficacy

Locally ablative therapies for primary radiation failures: A review and critical assessment of the efficacy

Locally ablative therapies for primary radiation failures: A review and critical assessment of the efficacy

Energy-based ablative therapy of prostate cancer: high-intensity focused ultrasound and cryoablation

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