Abstract:OBJECTIVE: The Fas ligand (FasL) system has an impact on inflammation and hypertension during pregnancy and is dysregulated in women with severe preeclampsia and HELLP syndrome. We have recently reported that endothelin antagonism impacted the Fas/FasL system, therefore in the current study we tested the hypothesis that neutralization of FasL in an animal model of HELLP syndrome decreases inflammation, improves endothelial damage and in turn improves hypertension. STUDY DESIGN: Mini-osmotic pumps infusing anti… Show more
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