1103 Relationship Between IL-10 and Dendritic Cells in Ovarian Cancer Microenvironment

Wertel, Iwona; Rogala, E.; Nowicka, Aldona; Jakubowicz-Gil, Joanna; Polak, Grzegorz; Tarkowski, Rafał; Kotarski, J

doi:10.1016/s0959-8049(12)71707-0

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“…CXCL12 levels were elevated in ovarian cancer patients compared to patients with serous cyst, as well as in FIGO III and IV patients compared with FIGO stage I patients. No significant differences were found in the plasma CXCL12 levels between different tumor grades 43 . Signals mediated by CXCL12 and its receptor CXCR4 were apparently involved in cancer progression by activating cancer cells, by inducing angiogenesis, and by recruiting T regulatory and plasmacytoid immune cells.…”

Section: Ascitic Fluid (Af)mentioning

confidence: 75%

Chemokines in tumor proximal fluids

Kotyza¹

2017

BIOMED PAP

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Chemokines are chemotactic cytokines produced by leukocytes and other types of cells including tumor cells. Their action is determined by the expression of cognate receptors and subsequent signaling in target cells, followed by the modulation of cytoskeletal proteins and the induction of other responses. In tumors, chemokines produced by neoplastic/stroma cells control the leukocyte infiltrate influencing tumor growth and progression. Tumor cells also express functional chemokine receptors responding to chemokine signals, promoting cell survival, proliferation and metastasis formation. Chemokines may be detected in serum of cancer patients, but due to the paracrine nature of these molecules, more significant concentrations are found in the tumor adjacent, non-vascular fluids, collectively called tumor proximal fluids. This review summarizes the expression of CC and CXC chemokines in these fluids, namely in interstitial fluid, pleural, ascitic, and cyst fluids, but also in urine, saliva, cerebrospinal fluid, cervical secretions and bronchoalveolar lavage fluid. Most comparative clinical studies reveal increased chemokine levels in high-grade tumor proximal fluids rather than in low-grade tumors and benign conditions, indicating shorter survival periods. The data confirm peritumoral fluid chemokines as sensitive diagnostic and prognostic markers, as well as offer support for chemokines and their receptors as potential targets for antitumor therapy.

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Section: Ascitic Fluid (Af)mentioning

confidence: 75%

Chemokines in tumor proximal fluids

Kotyza¹

2017

BIOMED PAP

View full text Add to dashboard Cite

show abstract

1103 Relationship Between IL-10 and Dendritic Cells in Ovarian Cancer Microenvironment

Cited by 1 publication

References 0 publications

Chemokines in tumor proximal fluids

Chemokines in tumor proximal fluids

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