11023-112 Exercise Training in Postinfarction Patients with Left Ventricular Dysfunction. Preliminary Results of the Exercise in Left Ventricular Dysfunction (ELVD) Trial

Exercise Training Post-MI Favorably Modifies Heart Extracellular Matrix in the Rat

“…Training in both patients and animal models is associated with improvements in exercise capacity as well as overall heart function after MI (11,23). These improvements in heart ñinction include increased maximal stroke volume (22), increased maximal heart rate, and normalization of end-diastolic pressure and wall stress (23).…”

Effects of exercise training on left ventricular volumes and function in patients with nonischemic cardiomyopathy: Application of magnetic resonance myocardial tagging

“…Although the patients with DCM in that study responded similarly to ours (eg, 27% increase in peak VO 2 , no change in left ventricular dimensions, no complications), the re-sponses among the patients with ischemic CHF differed from our previous findings 9,10,19 and the findings of other investigators. 1,3,7,8,17,18 In the latter studies, left ventricular volumes, ejection fraction, and mass remained unchanged after training regimens of various intensities, including high intensity training.…”

“…However, the available evidence during the last 10 years in humans has been consistent in the demonstration that training does not lead to further myocardial damage in such patients. 1,3,[7][8][9][10]19 Nearly all of the studies in CHF however, have been performed in patients with underlying ischemic heart disease; the effects of training in patients with nonischemic dilated CHF are largely unknown. In this study, patients randomized to the exercise group showed a 17% increase in peak VO 2 and a considerable (48%) increase in VO 2 at the lactate threshold.…”

“…3,4 Early reservations about potential adverse effects of training on the myocardial remodeling process in postinfarction CHF 5,6 have largely been allayed by recent studies with echocardiography, pulsed Doppler, and magnetic resonance imaging (MRI) of the left ventricle in humans before and after training. 1,3,[7][8][9][10] In contrast to some early reports in humans and animals, 5,6,11 these studies have shown that training does not lead to further ventricular dilatation, infarct expansion, or ventricular asynergy. However, nearly all the available data have come from patients with reduced ventricular function after myocardial infarction, underlying ischemia, or both, and few data are available on the effects of exercise training in nonischemic dilated cardiomyopathy (DCM).…”

Key components of physical rehabilitation for secondary prevention of cardiovascular diseases

“…ïîäòâåðäèëè óëó÷øåíèå ôóíêöèè è ïîëîaeèòåëüíîå ðåìîäåëèðîâàíèå ëåâîãî aeåëóäî÷êà ïðè âûïîëíåíèè ùàäÿùèõ óïðàaeíåíèé ïîñëå ÈÌ.  òå÷åíèå 6 ìåñÿöåâ ôðàêöèÿ âûáðîñà ëåâîãî aeåëóäî÷êà âûðîñëà ñ 34 äî 38 % [9].…”