11-[Bis(trimethylsilyl)amino]-2,4-bis(trimethylsilyl)-7,8,9,10-tetrahydro-6H-cyclohepta[1,2-b]quinoline

Abstract

In the title compound, C 26 H 48 N 2 Si 4 , the cycloheptane ring adopts a chair conformation, while the quinolinyl ring system is almost planar [maximum deviation = 0.040 (3) Å for one of the C atoms carrying a Me 3 Si group]. In the crystal, in the absence of classical hydrogen bonding, the packing is dominated by van der Waals forces. One of the N-bound trimethylsilyl groups is disordered by rotation about the C-SiMe 3 bond, and was modelled over two sets of sites in the ratio 0.873 (8):0.127 (8).

SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors

“…18 This study was carried out with disubstituted tacrine derivatives (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) according to our previous paper. 18,21,22…”

“…In our previous papers, 18,[21][22] one-pot synthesis was described for bromo tacrine derivatives (1-5) ( Figure 1) using Friedländer reactions of several cyclic ketones and brominated 2-amino-3,5-dibromobenzonitrile (17) in the presence of some Lewis acids. To achieve the direct bromination, tacrine was treated to methyl iodine to protect of the N atom in the cycle.…”