11-(4-Fluorophenyl)-7,11-dihydrobenzo[f]furo[3,4-b]quinolin-10(8H)-one

Abstract

Key indicatorsSingle-crystal X-ray study T = 298 K Mean (C-C) = 0.006 Å R factor = 0.049 wR factor = 0.136 Data-to-parameter ratio = 12.0 For details of how these key indicators were automatically derived from the article, see

Microwave‐assisted multicomponent reaction for the synthesis of new and significative bisfunctional compounds containing two furo[3,4‐b]quinoline and acridinedione skeletons

“…Among them, 4‐aza podophyllotoxin derivative 2 (Fig. 1) has been reported to be a powerful DNA topoisomerase inhibitor, working through a mechanism of action entirely different from that of the parent, natural podophyllotoxin [3, 4]. This suggests that substitution of the carbon atom at position 4 of podophyllotoxin by a nitrogen atom would bring about great changes in the biological profile.…”