“…Although arsenic has been considered as a poorer mutagen, increasing evidence suggests that arsenic is highly capable of promoting epigenetic alterations, including DNA methylation 9, 10 , histone methylation 11, 12 , histone phosphorylation/acetylation 13, 14 , and microRNA regulation 14, 15 , through some signaling mediators, e.g., ROS 16, 17 , Akt 15, 18, 19 , FilaminA 20 that are required for arsenic induced cell transformation. However, the mechanisms of how arsenic elicits those effects remain elusive.…”