1098 Cardiac Output Measurements in Preterm Neonates Requiring Resuscitation at Birth

Abstract

Abstracts labour ≤37°C, gestational age ≥37 weeks and birthweight centile ≥10%. Analysis was performed on plasma EDTA, using ELISA Quantikine® (R&D Systems, Europe). Results The study consisted of samples from 48 infants with two different modes of delivery; unassisted vaginal delivery (n=12 male, n=12 female) and pre-labour elective caesarean section (n=12 male, n=12 female). The range of all samples was normally distributed between 87.0 and 114.6 pg/ml. Mean (SD) for IL-16 was 103.1 (± 21.9) pg/ml. Levels were not affected by gender or mode of delivery. Conclusion For the first time we have described the expected range of cord plasma IL-16 levels in healthy term infants. Background and Aims Production of C-reactive protein (CRP), an acute phase reactant of hepatic origin, may be affected by perinatal asphyxia. This study tested hypotheses that circulatory CRP concentrations correlate with clinical severity of hypoxic-ischaemic encephalopathy (HIE) and that total body hypothermia modulates CRP response. Methods Clinical records in three centres were reviewed for neonates ≥36 weeks' gestation admitted between 01/07/06 and 30/06/11 with HIE of any severity (grades 1-3 Sarnat-Sarnat). Participating centres adopted routine cooling at different dates. Data extracted included CRP concentrations in the first postnatal week measured during routine clinical practice, clinical HIE grading, and reception of therapeutic hypothermia. Proportions with raised CRP (>10 mg/L), and maximum CRP concentrations were assessed according to HIE grade and whether cooled. Conclusion A raised CRP is a common finding in the first postnatal week in neonates admitted with HIE and is found in most infants with moderate-severe HIE. Peak CRP concentrations did not differ with clinical HIE grade and whole body hypothermia did not significantly affect peak CRP concentrations. C-REACTIVE PROTEIN CONCENTRATIONS IN NEONATES