1093 - Oxidative Stress Biomarkers in Patients with Irritable Bowel Syndrome (IBS)

Ramírez-García, Rosaelia; Escamilla-Diego, Ernesto; García-López, Barinia J.; Rosique, Dorothy; Charúa-Guindic, Luis; Gutiérrez-Reyes, Gabriela; Wasserman, Max J. Schmulson

doi:10.1016/s0016-5085(18)31108-9

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“…Changes in brain tissue oxidative stress status were similar to those observed in systemic and local biochemical markers in other IBS models and patients. Regarding the oxidative stress patterns in IBS patients, while Ramírez-García et al and Choghakhori et al found low antioxidant activity, Oran et al and Mete et al found intense lipid peroxidation processes and high inflammatory cytokines activity in blood sera [25][26][27][28]. Furthermore, a recent study indicates several of these oxidative markers, as well as some inflammatory parameters, to be IBS biomarkers [29].…”

Section: Discussionmentioning

confidence: 99%

Preliminary Biochemical Description of Brain Oxidative Stress Status in Irritable Bowel Syndrome Contention-Stress Rat Model

et al. 2019

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Background and objectives: Oxidative stress and inflammation have been implicated in the etiology of irritable bowel syndrome (IBS), a common gastrointestinal functional disease. This study aimed to further characterize the contention-stress rat model by exploring a possible correlation between oxidative stress markers measured in brain tissues with behavioral components of the aforementioned model. Thus, it is hereby proposed a possible IBS animal model relevant to pharmacological and complementary medicine studies. Materials and Methods: Wild-type male Wistar rats (n = 5/group) were chronically exposed to 6-hour/day contention, consisting of isolating the animals in small, vital space-granting plastic devices, for seven consecutive days. Following contention exposure, temporal lobes were extracted and subjected to biochemical analyses to assess oxidative stress-status parameters. Results: Our results show increased brain oxidative stress in contention-stress rat model: decreased superoxide dismutase and glutathione peroxidase activities and increased malondialdehyde production in the IBS group, as compared to the control group. Furthermore, the biochemical ratios which are used to evaluate the effectiveness of an antioxidant system on oxidative stress could be described in this model. Conclusions: The correlations between the behavioral patterns and biochemical oxidative stress features could suggest that this may be a complex model, which can successfully mimic IBS symptomatology further providing evidence of a strong connection between the digestive system, enteric nervous system, and the central nervous system.

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Section: Discussionmentioning

confidence: 99%