1085 – Neuronal Serotonin As a Link Between Depression and Constipation: A Role for Simultaneous Treatment with a Novel Slow-Release Formulation of the Serotonin Precursor, 5-Hydroxytryptophan

Colle, Andrew Del; Israelyan, Narek; Li, Zhishan; Park, Yeji; Luna, Ruth Ann; Jensen, Dane D.; Xing, Albert; Venkatachalam, Alamelu; Latorre, Rocco; Jacobsen, Jacob P. R.; Madra, Moneek; Bunnett, Nigel W.; Caron, Marc G.; Gershon, Michael D.; Margolis, Kara Gross

doi:10.1016/s0016-5085(19)37370-6

Cited by 2 publications

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“…The agnostic approach used here made it possible to identify other potential new risk factors for AD. Constipation has already been linked to depression 6 and has been identified as a symptom in some neurodegenerative diseases, such as Lewy body dementia and Parkinson’s disease 32 . To our knowledge, this is the first time that constipation has been shown to be associated with a risk of AD.…”

Section: Discussionmentioning

confidence: 99%

Data-driven identification of health conditions associated with incident Alzheimer’s disease dementia risk: a 15 years follow-up cohort from electronic health records in France and the United Kingdom

Nedelec

Couvy‐Duchesne

Monnet

et al. 2021

Preprint

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Importance. The identification of modifiable risk factors for Alzheimer s disease (AD) is paramount for early prevention and the targeting of new interventions. Objective. To assess the associations between health conditions diagnosed in primary care and the risk of incident AD over time. Design, Setting, and Participants. Data for 20,214 AD patients from the United Kingdom and 19,458 AD patients from France were extracted from The Health Improvement Network (THIN) database. For each AD case, a control was randomly assigned after matching for sex and age at dementia diagnosis. We agnostically tested the associations between 123 different ICD10 diagnoses extracted from health records and AD dementia, by conditional logistic regression. We focused on two time periods: 2 to 10 years vs. 0 to 2 years before the diagnosis of AD, to separate risk factors from early symptoms/comorbidities. Exposures. We considered all health conditions that had been recorded in more than 0.1% of visits per 1000 person-years in both cohorts, corresponding to 123 potential types of exposure. Main Outcomes and Measures. Odds ratios (ORs) for the association of AD with the various health conditions were calculated after Bonferroni correction for multiple comparisons. Results. Ten health conditions were significantly associated with high odds ratios for AD when diagnosed 2 to 10 years before AD, in the British and French samples: major depressive disorder (OR 95% confidence interval (UK):1.23-1.46)), anxiety (1.25-1.47), reaction to severe stress (1.24-1.59), hearing loss (1.11-1.28), constipation (1.22-1.41), spondylosis (1.14-1.39), abnormal weight loss (1.33-1.63), malaise and fatigue (1.14-1.32), memory loss (6.65-8.76) and syncope and collapse (1.1-1.37). Depression was the first comorbid condition associated with AD, appearing at least nine years before the first clinical diagnosis of AD, followed by, anxiety, constipation and abnormal weight loss. Conclusions and Relevance. These results from two independent primary care databases provide new evidence on the temporality of risk factors and early signs of Alzheimer s disease. These results could guide new dementia prevention strategies.

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Section: Discussionmentioning

confidence: 99%

Data-driven identification of health conditions associated with incident Alzheimer’s disease dementia risk: a 15 years follow-up cohort from electronic health records in France and the United Kingdom

Nedelec

Couvy‐Duchesne

Monnet

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The agnostic approach used here made it possible to identify other potential new risk factors for Alzheimer's disease. Constipation has already been linked to depression 26 and has been identified as a symptom in some neurodegenerative diseases, such as Lewy-body dementia and Parkinson's disease. 14 To our knowledge, this is the first time that constipation has been shown to be associated with a risk of Alzheimer's disease.…”

Section: Anxietymentioning

confidence: 99%

Identifying health conditions associated with Alzheimer's disease up to 15 years before diagnosis: an agnostic study of French and British health records

Nedelec

Couvy‐Duchesne

Monnet

et al. 2022

The Lancet Digital Health

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1085 – Neuronal Serotonin As a Link Between Depression and Constipation: A Role for Simultaneous Treatment with a Novel Slow-Release Formulation of the Serotonin Precursor, 5-Hydroxytryptophan

Cited by 2 publications

References 0 publications

Data-driven identification of health conditions associated with incident Alzheimer’s disease dementia risk: a 15 years follow-up cohort from electronic health records in France and the United Kingdom

Data-driven identification of health conditions associated with incident Alzheimer’s disease dementia risk: a 15 years follow-up cohort from electronic health records in France and the United Kingdom

Identifying health conditions associated with Alzheimer's disease up to 15 years before diagnosis: an agnostic study of French and British health records

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