1045 Quality-of-life assessment following surgery with or without postoperative radiation therapy for squamous cell carcinoma of the tongue base

Nisi, Kurt; Earle, Julie M.; Foote, Robert L.

doi:10.1016/s0360-3016(97)85556-3

Cited by 7 publications

(5 citation statements)

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“…Nisi et al 73 performed the same functional analysis on 21 patients (S alone, 13 patients; S and postoperative RT, 8 patients) who underwent operation at the Mayo Clinic. Eighty‐one percent of patients had early‐stage disease (T1–T2).…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of the oropharynx

Parsons

Mendenhall

Stringer

et al. 2002

Cancer

404

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BACKGROUND The treatment of patients with squamous cell carcinoma (SCC) of the oropharynx remains controversial. No randomized trial has addressed adequately the question of whether surgery (S), radiation therapy (RT), or combined treatment is most effective. METHODS Treatment results from North American academic institutions that used S with or without adjuvant RT (S ± RT) or used RT alone or followed by neck dissection (RT ± ND) for patients with SCC of the tonsillar region or the base of tongue were compiled through a MEDLINE search (from 1970 to August, 2000) and from the references cited in each report. Studies were eligible for inclusion if they contained direct, actuarial (life‐table), or Kaplan–Meier calculations for the following end points: local control, local‐regional control, 5‐year absolute survival, 5‐year cause specific survival, or severe or fatal treatment complications. Weighted average results, which took into account series size, were calculated for each end point for the purposes of treatment comparison. Results and conclusions were based on data from 51 reported series, representing the treatment of approximately 6400 patients from the United States and Canada. RESULTS The results for patients with SCC of the base of tongue who underwent S ± RT versus RT ± ND, respectively, were as follows: local control, 79% versus 76% (P = 0.087); local‐regional control, 60% versus 69% (P = 0.009); 5‐year survival, 49% versus 52% (P = 0.2); 5‐year cause specific survival, 62% versus 63% (P = 0.4); severe complications, 32% versus 3.8% (P < 0.001); and fatal complications, 3.5% versus 0.4% (P < 0.001). The results for patients with SCC in the tonsillar region who underwent S ± RT versus RT ± ND, respectively, were as follows: local control, 70% versus 68% (P = 0.2); local‐regional control, 65% versus 69% (P = 0.1); 5‐year survival, 47% versus 43% (P = 0.2); 5‐year cause specific survival, 57% versus 59% (P = 0.3); severe complications, 23% versus 6% (P < 0.001); and fatal complications, 3.2% versus 0.8% (P < 0.001). CONCLUSIONS The information in this article provides a useful benchmark for evidence‐based counseling of patients with SCC of the oropharynx. The rates of local control, local‐regional control, 5‐year survival, and 5‐year cause specific survival were similar for patients who underwent S ± RT or RT ± ND, whereas the rates of severe or fatal complications were significantly greater for the S ± RT group. Furthermore, available data on the functional consequences of treatment suggest the superiority of RT ± ND. The authors conclude that RT ± ND is preferable for the majority of patients with SCC of the oropharynx. Cancer 2002;94:2967–80. © 2002 American Cancer Society. DOI 10.1002/cncr.10567

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Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of the oropharynx

Parsons

Mendenhall

Stringer

et al. 2002

Cancer

404

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“…In 10 patients who underwent primary surgery and postoperative radiation therapy, Harrison et al 29 found some mean performance status scores of 50% (for those with T1 or T2 tumors) and 32% (for those with T3 or T4 tumors) for normalcy of diet and 65% (for those with T1 or T2 tumors) and 35% (for those with T3 or T4 tumors) for understandability of speech. For the same treatment modality, Nisi et al 30 obtained scores of 56% for normalcy of diet and 84% for understandability of speech; however, for a group of patients who underwent surgery alone, mainly partial glossectomy, they found scores of 91% and 96%, respectively. 15,30 For patients who underwent total glossectomy, Ruhl et al 27 reported mean performance status scores of 28.6% for normalcy of diet and 46.4% for understandability of speech.…”

Section: Foote Et Almentioning

confidence: 99%

“…For the same treatment modality, Nisi et al 30 obtained scores of 56% for normalcy of diet and 84% for understandability of speech; however, for a group of patients who underwent surgery alone, mainly partial glossectomy, they found scores of 91% and 96%, respectively. 15,30 For patients who underwent total glossectomy, Ruhl et al 27 reported mean performance status scores of 28.6% for normalcy of diet and 46.4% for understandability of speech. Two of the 7 patients had also undergone a total laryngectomy (all had T3 or T4 tumors).…”

Section: Commentmentioning

confidence: 99%

Transoral Laser Microsurgery for Squamous Cell Carcinoma of the Base of the Tongue

Steiner

Fierek²,

Ambrosch³

et al. 2003

Arch Otolaryngol Head Neck Surg

204

135

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“…Clinical trials 25,[27][28][29] have shown improvements in scores with time from treatment, which is an indicator of responsiveness. A survey of 47 of 61 disease-free survivors of chemoradiotherapy 26 showed a moderate Spearman correlation between FACT-H&N and number of "troublesome" symptoms reported, but did not show any significant differences with time since treatment vs. 23 months.…”

Section: The Functional Assessment Of Cancer Therapy -Head and Neck (mentioning

confidence: 99%

A structured review of quality of life instruments for head and neck cancer patients

2001

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1045 Quality-of-life assessment following surgery with or without postoperative radiation therapy for squamous cell carcinoma of the tongue base

Cited by 7 publications

References 0 publications

Squamous cell carcinoma of the oropharynx

Squamous cell carcinoma of the oropharynx

Transoral Laser Microsurgery for Squamous Cell Carcinoma of the Base of the Tongue

A structured review of quality of life instruments for head and neck cancer patients

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