1026 Role of booster dose to the tumor bed in breast conservative treatment—phase III study

Romestaing, P.; Lehingue, Y; Ardiet, J.M.; Page, Gayle G.; Mamelle, N; Carrié, C.; Gérard, Jean-Pierre

doi:10.1016/0959-8049(95)96274-h

Cited by 2 publications

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“…It is well established that whole breast irradiation after breast-conserving surgery is useful in the reduction of local recurrences but the role of boost irradiation to the tumor bed is unknown. A large prospective randomized trial (European Organization for Research and Treatment of Cancer 22881 ) is at present being carried out to evalu ate this issue [14]. Until the results of this trial are avail able, it is advisable to make every effort to attain a nega tive surgical margin because at present it is not known whether or not boost irradiation is a safe alternative for the reexcision in cases of a positive surgical margin.…”

Section: Discussionmentioning

confidence: 99%

A Case-Control Study on Risk Factors for Local Recurrences or Distant Metastases in Breast Cancer Patients Treated with Breast-Conserving Surgery

Noguchi¹,

Koyama²,

Kasugai³

et al. 1997

Oncology

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A case-control study was conducted on 143 case-control sets recruited from the 18 key hospitals/institutes in Japan to identify risk factors for local recurrences and distant metastases after breast-conserving surgery in breast cancer patients: (1) positive surgical margin was a risk factor for local recurrences (relative risk (RR) = 16.70, p < 0.001) but not for distant metastases, (2) positive p53 immunostaining was a risk factor for both local recurrences (RR = 5.62, p = 0.003) and distant metastases (RR = 3.11, p = 0.034), (3) lymph node metastasis was a risk factor for distant metastases (RR = 9.28, p = 0.001) but not for local recurrences, (4) radiation therapy reduced local recurrences (RR = 0.13, p = 0.004) and (5) adjuvant chemotherapy (RR = 0.27, p = 0.120), endocrine therapy (RR = 0.21, p = 0.037), and chemoen-docrine therapy (RR = 0.05, p = 0.013) reduced local recurrences.

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Section: Discussionmentioning

confidence: 99%

A Case-Control Study on Risk Factors for Local Recurrences or Distant Metastases in Breast Cancer Patients Treated with Breast-Conserving Surgery

Noguchi¹,

Koyama²,

Kasugai³

et al. 1997

Oncology

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“…The role of boost irradiation in reducing the risk of local recurrence for patients with a negative or positive margin is still under investigation, in the European Organization for Research and Treatment of Cancer 22881 trial. 17 Another possible explanation is the short follow-up period in our study for patients with a positive margin compared with that for patients having a negative margin (32 vs 46 months). From September 1995, we changed our method of BCT to lumpectomy followed by RT to the whole breast, as a substitute for quadrantectomy without RT.…”

Section: Role Of Radiation Therapy and Adjuvant Endocrine Therapymentioning

confidence: 90%

Risk factors for local recurrence after breast-conserving therapy

Shin

Takatsuka

Okamura³

et al. 1999

International Journal of Clinical Oncology

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a significant independent risk factor for local recurrence, while radiation therapy (P ϭ 0.0457) significantly decreased recurrence. In patients with a negative surgical margin, radiation therapy (P ϭ 0.0158) and adjuvant endocrine therapy (P ϭ 0.0421) significantly reduced the relative risk of local recurrence, to 0.160 and 0.366, respectively. In patients with a positive surgical margin, radiation therapy marginally significantly (P ϭ 0.0756) reduced the relative risk of local recurrence, to 0.181, and adjuvant endocrine therapy significantly (P ϭ 0.0119) reduced the risk, to 0.076. Conclusions. Young age and lack of radiation therapy or adjuvant endocrine therapy were risk factors for local recurrence in breast cancer patients treated with breastconserving therapy, with surgical margin status also being a possible risk factor. AbstractBackground. Breast-conserving therapy has been widely accepted as a standard treatment for early breast cancer both in Western countries and in Japan. In Western countries, many studies have investigated the risk factors for local recurrence after breast-conserving therapy (BCT), but few such studies have been done in Japan. Methods.To determine the risk factors for local recurrence in 399 breast cancer patients (stage I and II, n ϭ 396; stage III, n ϭ 3) who had undergone BCT with or without postoperative radiation therapy, we evaluated their clinicopathological features by univariate and multivariate analyses. The patients were treated at Osaka National Hospital between February 1988 and December 1997. Results. Univariate analysis showed that a young age (Յ45 years; P ϭ 0.0005) was a significant risk factor for local recurrence, while radiation therapy (P ϭ 0.0058) and adjuvant endocrine therapy (P ϭ 0.0041) significantly reduced the risk of local recurrence. In patients with BCT, without radiation therapy a positive surgical margin significantly increased the risk of local recurrence (P ϭ 0.0470). Multivariate analysis showed that a young age (P ϭ 0.0285) was

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1026 Role of booster dose to the tumor bed in breast conservative treatment—phase III study

Cited by 2 publications

References 0 publications

A Case-Control Study on Risk Factors for Local Recurrences or Distant Metastases in Breast Cancer Patients Treated with Breast-Conserving Surgery

A Case-Control Study on Risk Factors for Local Recurrences or Distant Metastases in Breast Cancer Patients Treated with Breast-Conserving Surgery

Risk factors for local recurrence after breast-conserving therapy

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