1021 Pan-Colonic Pressurizations Associated With Relaxation of the Anal Sphincter in Man: A Highly Prevalent Colonic Motor Event Identified Using High-Resolution Manometry and Associated With Feeling and Desire to Evacuate Gas

Corsetti, Maura; Pagliaro, Giuseppe; Demedts, Ingrid; Scheerens, Charlotte; Rommel, Nathalie; Tack, Jan; Deloose, Eveline

doi:10.1016/s0016-5085(15)30638-7

Cited by 4 publications

(6 citation statements)

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“…Neurogenic slow propagation of haustrations might also occur in humans but has not yet been convincingly demonstrated. The neurogenic CMC elicited by continuous distension of the animal colon 42,81 might correspond to the simultaneous and quasi-simultaneous motor complexes described in the isolated human colon in vitro 86,87 and to the repetitive pan-colonic simultaneous events (pressurizations) described in humans in vivo that occur at a frequency of ~1 per minute 7,8,196 . The widely described ripples in the colon of animals, generated by slow waves, have also been identified in vitro in the human colon where they generate regular contractions at 2-6 cpm, and are termed intermediatefrequency contractions.…”

Section: Discussionmentioning

confidence: 92%

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques

Corsetti

Costa

Bassotti

et al. 2019

Nat Rev Gastroenterol Hepatol

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122

130

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Section: Discussionmentioning

confidence: 92%

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques

Corsetti

Costa

Bassotti

et al. 2019

Nat Rev Gastroenterol Hepatol

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122

130

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“…Interestingly, slower myogenic activity in vivo has been recorded with high‐resolution manometry recordings in both healthy controls and patients with constipation and can allow a validation of in vitro observation.…”

Section: Discussionmentioning

confidence: 99%

Opposite effects of dopamine on the mechanical activity of circular and longitudinal muscle of human colon

Zizzo

Bellanca

Amato

et al. 2020

Neurogastroenterology Motil

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The idea of a dopaminergic enteric transmission, independent of the sympathoadrenal system, has been proposed different years ago due to the observations that neurons, expressing both the dopamine (DA)-synthesizing enzyme and the dopamine transporter, but not the norepinephrine-synthesizing enzyme, were present within the enteric nervous system (ENS) in both animal models and humans. 1,2 DA seems to be implicated in several functions in GI tract, 3 activating specific receptors belonging to the G protein-coupled receptor family categorized in two main families: D1-like receptor (D1 and D5 receptors) and D2-like receptor(D2, D3, and D4 receptors), present from the stomach through the distal colon in different animal species. 2 Abstract Background: Because dopamine (DA) has gained increasing evidence as modulator of gut motility, we aimed to characterize dopaminergic response in human colon, evaluating function and distribution of dopamine receptors in circular vs longitudinal muscle strips. Methods: Mechanical responses to DA and dopaminergic agonists on slow phasic contractions and on basal tone were examined in vitro as changes in isometric tension. RT-PCR was used to reveal the distribution of dopaminergic receptors. Key Results: In spontaneous active circular muscle, DA induced an increase in the amplitude of slow phasic contractions and of the basal tone, via activation of D1-like receptors. DA contractile responses were insensitive to neural blockers or to atropine and inhibited by phospholipase C (PLC) pathway inhibitors. In precontracted circular muscle strips, DA, at the higher concentrations tested, caused a relaxant response via activation of D2-like receptors. In the longitudinal muscle, DA caused only muscular relaxation due to activation of D2-like receptors. DA relaxant responses were insensitive to neural blockers or to nitric oxide synthase inhibitor and reduced by a wide-spectrum K + channel blockers. Transcripts encoding for all the dopaminergic receptor subtypes was observed in both circular and longitudinal preparations. Conclusions and inferences: Dopamine is able to modulate contractile activity of the human colon. In the circular muscle layer, DA induces mainly muscular contraction activating non-neural D1-like receptors, coupled to PLC/IP3 pathway. In the longitudinal muscle layer, DA induces muscular relaxation acting on non-neural D2-like receptors leading to the increase in K + conductance. K E Y W O R D S circular and longitudinal muscle, dopamine, dopaminergic receptors human colon, intestinal motility

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“…However, in recent high‐resolution manometry recordings a ‘pan‐colonic pressurization’ has been described (Corsetti et al . ). This motor pattern consists of a pressure increase of 15 ± 3 mmHg amplitude and 24 ± 4 s duration, which occurs simultaneously in all colonic sensors (Corsetti et al .…”

Section: Colonic Motilitymentioning

confidence: 97%

“…This motor pattern consists of a pressure increase of 15 ± 3 mmHg amplitude and 24 ± 4 s duration, which occurs simultaneously in all colonic sensors (Corsetti et al . ). These motor patterns are recorded in both healthy controls and patients with constipation and can occur in isolation or in a rhythmic pattern ranging from 3 min −1 to ∼1 min −1 (Fig.…”

Section: Colonic Motilitymentioning

confidence: 97%

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Insights into the mechanisms underlying colonic motor patterns

Spencer

Dinning

Brookes

et al. 2016

The Journal of Physiology

125

115

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In recent years there have been significant technical and methodological advances in our ability to record the movements of the gastrointestinal tract. This has led to significant changes in our understanding of the different types of motor patterns that exist in the gastrointestinal tract (particularly the large intestine) and in our understanding of the mechanisms underlying their generation. Compared with other tubular smooth muscle organs, a rich variety of motor patterns occurs in the large intestine. This reflects a relatively autonomous nervous system in the gut wall, which has its own unique population of sensory neurons. Although the enteric nervous system can function independently of central neural inputs, under physiological conditions bowel motility is influenced by the CNS: if spinal pathways are disrupted, deficits in motility occur. The combination of high resolution manometry and video imaging has improved our knowledge of the range of motor patterns and provided some insight into the neural and mechanical factors underlying propulsion of contents. The neural circuits responsible for the generation of peristalsis and colonic migrating motor complexes have now been identified to lie within the myenteric plexus and do not require inputs from the mucosa or submucosal ganglia for their generation, but can be modified by their activity. This review will discuss the recent advances in our understanding of the different patterns of propagating motor activity in the large intestine of mammals and how latest technologies have led to major changes in our understanding of the mechanisms underlying their generation.

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1021 Pan-Colonic Pressurizations Associated With Relaxation of the Anal Sphincter in Man: A Highly Prevalent Colonic Motor Event Identified Using High-Resolution Manometry and Associated With Feeling and Desire to Evacuate Gas

Cited by 4 publications

References 0 publications

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques

Opposite effects of dopamine on the mechanical activity of circular and longitudinal muscle of human colon

Insights into the mechanisms underlying colonic motor patterns

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