102 GTx-758, an ERα agonist, reduces serum free testosterone lower than can be achieved by leuprolide with a significantly lower rate of hot flashes in men with advanced prostate cancer

Getzenberg, Robert H.; Coss, Christopher C.; Hancock, Michael L.; Dalton, James T.; Steiner, M.S.

doi:10.1016/s1569-9056(13)60594-1

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2014

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“…This has the added effect of decreasing free testosterone even further and reducing adrenal androgens and intratumoral testosterone. 35,41-43 In a small study, Levell et al 34 assessed the relationship of total and free testosterone and survival in men with advanced prostate cancer after orchiectomy or treatment with estrogens. Although total testosterone levels were not different among groups, free testosterone levels were lower in estrogen-treated patients.…”

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confidence: 99%

Maximal Testosterone Suppression in Prostate Cancer—Free vs Total Testosterone

Rove

Crawford

Perachino³

et al. 2014

Urology

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Testosterone remains a key target in the treatment of advanced prostate cancer. The relationship of free testosterone to prostate cancer treatment and outcomes remains largely unexplored. A consensus of prostate cancer experts was convened in 2013 to review current knowledge surrounding relationship of total and free testosterone to prostate cancer, discuss the free hormone hypothesis, and highlight future avenues for therapeutics. Free testosterone may better reflect prostate cancer tissue androgen levels than serum total testosterone concentration. Free testosterone deserves more research regarding its relation to clinical outcomes.

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