1010 Nummular eczema is a distinct clinical entity with overlapping features of both, psoriasis and atopic eczema

Boehner, Alexander; Lauffer, Felix; Biedermann, Tilo; Eyerich, Kilian

doi:10.1016/j.jid.2018.03.1022

Cited by 1 publication

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“…It is unknown how these allergens, particularly formaldehyde and formaldehyde releasers, specifically relate to NE. We speculate that these allergens may induce a T‐helper (Th‐)17 and/or Th2 response in skin, 34 which have both been shown to be upregulated in NE 35 . Alternatively, patients with NE may have developed secondary ACD through application of emollients and topical medications to their NE lesions.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and trend of allergen sensitization in patients with nummular (discoid) eczema referred for patch testing: North American Contact Dermatitis Group data, 2001–2016

et al. 2021

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Background Few studies have examined the relationship between nummular (discoid) eczema (NE) and allergic contact dermatitis (ACD). Objective To examine trends, associations, and clinical relevance of ACD in patients with NE who were referred for patch testing. Methods Retrospective analysis of 38 723 patients from the North American Contact Dermatitis Group. Results Overall, 748 patients (1.9%) were diagnosed with NE; 23.9% had a concomitant diagnosis of ACD. The prevalence of NE fluctuated over time between 2001 and 2016, with no overall change in prevalence in diagnosed NE. In multivariable logistic regression models, NE increased steadily with age and was associated with male sex and Asian and other race/ethnicity, and inversely associated with a history of atopic dermatitis (AD) and hay fever. Patients with NE had lower proportions of one or more positive allergic reactions and lower odds of a positive reaction in multiple individual allergens. The most commonly relevant allergens in patients with NE were formaldehyde 2.0% aq., methylisothiazolinone, quaternium 15, fragrance mix I, and propylene glycol. Conclusion NE is a heterogeneous disorder with distinct subsets of lesional distributions and a profile of relevant allergens, especially formaldehyde and formaldehyde releasers. Nearly one in four patients with NE had ACD, supporting the role of patch testing in patients with NE.

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Section: Discussionmentioning

confidence: 99%

“…and/or Th2 response in skin, 34 which have both been shown to be upregulated in NE. 35 Alternatively, patients with NE may have developed secondary ACD through application of emollients and topical medications to their NE lesions. is rare in children.…”

Section: Spinmentioning

confidence: 99%