1008 Decreased Fecal Microbial Metabolite Enterolactone is a Novel Inflammatory and Oxidative Stress Related Biomarker of Alcoholic Liver Disease

Puri, Puneet; Mirshahi, Faridoddin; Siddiqui, Mohammad Shadab; Boyett, Sherry; Sargeant, Carol; Joyce, Andrew; Luketic, Velimir A.; Sanyal, Arun J.

doi:10.1016/s0016-5085(15)33416-8

Cited by 1 publication

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“…It has been found to inhibit ß-oxidation and intracellular lipid metabolism, contributing to the progression of NAFLD [ 62 ]. Reduced fecal microbial metabolite enterolactone is considered a novel biomarker associated with inflammatory and oxidative stress in alcoholic liver disease [ 63 ]. Therefore, the increased content of ENL in the flaxseed lignan group suggests that flaxseed lignan attenuates PAM-induced hepatotoxicity by improving oxidative state and fatty acid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Flaxseed Lignan Alleviates the Paracetamol-Induced Hepatotoxicity Associated with Regulation of Gut Microbiota and Serum Metabolome

Ren,

Xu,

Qiao

et al. 2024

Nutrients

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This study examined the protective effect of flaxseed lignans on liver damage caused by an overdose of paracetamol (PAM). The findings demonstrated that administering 800 mg/kg/d flaxseed lignan prior to PAM significantly decreased the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBi) levels, while it increased liver superoxide dismutase (SOD) and glutathione (GSH) levels in mice. Flaxseed lignan renovated the gut microbiota dysbiosis induced by PAM by promoting the proliferation of sulfonolipid (SL) producing bacteria such as Alistipes and lignan-deglycosolating bacteria such as Ruminococcus while inhibiting the growth of opportunistic pathogen bacteria such as Acinetobacter and Clostridium. Furthermore, flaxseed lignan modulated the serum metabolomic profile after PAM administration, specifically in the taurine and hypotaurine metabolism, phenylalanine metabolism, and pyrimidine metabolism. The study identified eight potential biomarkers, including enterolactone, cervonyl carnitine, acutilobin, and PC (20:3(5Z, 8Z, 11Z)/20:0). Overall, the results suggest that flaxseed lignan can alleviate PAM-induced hepatotoxicity and may be beneficial in preventing drug-induced microbiome and metabolomic disorders.

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Section: Discussionmentioning

confidence: 99%