1004 Solifenacin in Neurogenic Overactive Bladder

Spinelli, M.; Citeri, M.; Zanollo, L.; Redaelli, Tiziana

doi:10.1016/s1569-9056(07)60999-3

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…31 Three studies, one with darifencin 32 and two with solifenacin were open-label, noncomparative studies. 33,34 Three studies investigated long-term outcomes of propiverine IR, 35 and fesoterodine, 36 another open-label retrospective study compared tolterodine with oxybutynin. 37 The studies of Tan and Toh, 37 and Yamanishi et al 31 lack important study details.…”

Section: Study Characteristicsmentioning

confidence: 99%

Neurogenic detrusor overactivity in adults: a review on efficacy, tolerability and safety of oral antimuscarinics

Madersbacher

Mürtz²,

Stöhrer

2013

Spinal Cord

View full text Add to dashboard Cite

Objectives: This review analyzed efficacy, tolerability and safety of oral antimuscarinic (AM) drugs in adults suffering from neurogenic detrusor overactivity (NDO). Methods: A comprehensive search of major literature bases was conducted to identify all references. Results: Thirty studies, thereof 16 randomized controlled trials (RCT), enrolling 1479 patients were identified and included in the review. Results were grouped in dose-finding, placebo-and active-controlled, flexible dose and combined high-dose AM drugs, and various studies. Key urodynamic outcome parameters, such as maximum detrusor pressure and maximum cystometric bladder capacity, demonstrated the efficacy of AM in NDO, following 2-3 weeks of treatment. Contrary to idiopathic detrusor overactivity (IDO), no placebo effects manifested. Other important parameters, such as impact on the upper urinary tract function and morphology, issues of continence, post-void residual urine, catheterisation, urinary tract infections and quality of life, were investigated to a limited extent only. Incidence rates of adverse events were comparable for NDO and IDO. Most of the studies, especially RCT, were undertaken with oxybutynin immediate release (IR), trospium chloride IR, propiverine IR and propiverine extended release. In NDO, these drugs are best investigated. Conclusions: AM drugs are effective in NDO, they normalize the intravesical pressure and increase cystometric bladder capacity. However, other important parameters are not adequately investigated so far and should be recognized in future studies.

show abstract