1000 Liver Transplantations at the Department of General, Transplant and Liver Surgery, Medical University of Warsaw - Analysis of Indications and Results

Krawczyk, Marek; Grąt, Michał; Barski, Krzysztof; Ligocka, Joanna; Antczak, Arkadiusz; Kornasiewicz, Oskar; Skalski, Michał; Patkowski, Waldemar; Nyckowski, P; Zieniewicz, Krzysztof; Grzelak, I; Pawlak, Jacek; Alsharabi, A.; Wróblewski, Tadeusz; Paluszkiewicz, Rafał; Najnigier, B; Dudek, Krzysztof; Remiszewski, Piotr; Smoter, Piotr; Grodzicki, Mariusz; Korba, Michał; Kotulski, Marcin; Cieślak, Bartosz; Kalinowski, Piotr; Gierej, Piotr; Frączek, Mariusz; Rdzanek, Łukasz; Stankiewicz, Rafał; Kobryń, Konrad; Nazarewski, Łukasz; Leonowicz, D.; Urban-Lechowicz, Magdalena; Skwarek, Anna; Giercuszkiewicz, Dorota; Paczkowska, A; Piwowarska, Jadwiga; Gelo, Remigiusz; Andruszkiewicz, Paweł; Brudkowska, Anna; Andrzejewska, Renata; Niewiński, Grzegorz; Kilińska, Beata; Zarzycka, Aleksandra; Nowak, Robert; Kosiński, C; Korta, T; Ołdakowska‐Jedynak, Urszula; Sańko-Resmer, Joanna; Foroncewicz, Bartosz; Ziółkowski, Jerzy; Mucha, Krzysztof; Senatorski, G; Pączek, Leszek; Habior, Andrzej; Lechowicz, Robert; Polański, Sławomir; Leowska, E; Pacho, Ryszard; Andrzejewska, Małgorzata; Rowiński, Olgierd; Kozieł, Sławomir; Zurakowski, J; Ziarkiewicz‐Wróblewska, Bogna; Górnicka, Barbara; Hevelke, Piotr; Michałowicz, B; Karwowski, A; Szczerbań, J

doi:10.2478/v10035-012-0051-y

Cited by 28 publications

(29 citation statements)

References 38 publications

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“…autoimmune diseases, were confirmed by numerous reports, also on the basis of material of our Department (1,2,27).…”

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confidence: 71%

“…The demonstrated structure of indications to 1,500 liver transplantation does not differ from this presented in the previous publication (8). Infections with hepatotropic viruses, HCV and HBV, were the most common.…”

Section: Resultsmentioning

confidence: 59%

“…Furthermore, such number of procedures performed annually is compatible with values reported by the largest transplantation centers worldwide (9, 10, 11). As compared to the previous collective analysis of outcomes of the liver transplantation at the Department of General, Transplant and Liver Surgery, Medical University of Warsaw, further reduction of an early (30-day) postoperative mortality from 8.9% to 7.3% after primary transplantation and from 34.5% to 29.2% after retransplantation must be emphasized (8). This report also present detailed evolution of long-term outcomes of transplantation, expressed as an overall 5-year survival rates and 5-year graft survival rates.…”

Section: Resultsmentioning

confidence: 89%

“…Furthermore, transplantation is gaining more and more importance in the treatment of patients with selected liver malignancies. 5) and cirrhosis caused by autoimmune hepatitis (AIH) (1,2). On the other hand, the lowest rates of long-term, 5-year survival were achieved in patients undergoing liver transplantation due to cirrhosis caused by HCV infection and HCC (2).…”

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confidence: 99%

“…piggyback with sparing of retrohepatic segment of the inferior vena cava and conventional that involved its resection and use of a temporary veno-venous extracorporeal circulation using so called biopump. The utilized surgical techniques were described in detail in the previous publication (8). Immunosuppression involved most often induction using anti-CD25 and utilization of various combinations of glycocorticosteroids, calcineurin inhibitors and mycophenolate mofetil.…”

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confidence: 99%

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Evolution Of The Results Of 1500 Liver Transplantations Performed In The Department Of General, Transplant And Liver Surgery Medical University Of Warsaw

Krawczyk¹,

Grąt²,

Grąt³

et al. 2015

Polish Journal of Surgery

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Liver transplantation is a well-established treatment of patients with end-stage liver disease and selected liver tumors. Remarkable progress has been made over the last years concerning nearly all of its aspects. the aim of this study was to evaluate the evolution of long-term outcomes after liver transplantations performed in the Department of General, Transplant and Liver Surgery (Medical University of Warsaw). material and methods. Data of 1500 liver transplantations performed between 1989 and 2014 were retrospectively analyzed. Transplantations were divided into 3 groups: group 1 including first 500 operations, group 2 including subsequent 500, and group 3 comprising the most recent 500. Five year overall and graft survival were set as outcome measures. Results. Increased number of transplantations performed at the site was associated with increased age of the recipients (p<0.001) and donors (p<0.001), increased rate of male recipients (p<0.001), andBrought to you by | MIT Libraries Authenticated Download Date | 5/11/18 7:58 AM

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“…autoimmune diseases, were confirmed by numerous reports, also on the basis of material of our Department (1,2,27).…”

Section: Brought To You By | Mit Librariessupporting

confidence: 71%

Section: Resultsmentioning

confidence: 59%

Section: Resultsmentioning

confidence: 89%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Evolution Of The Results Of 1500 Liver Transplantations Performed In The Department Of General, Transplant And Liver Surgery Medical University Of Warsaw

Krawczyk¹,

Grąt²,

Grąt³

et al. 2015

Polish Journal of Surgery

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Efficacy and Safety of Probiotics and Synbiotics in Liver Transplantation

et al. 2018

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This article summarizes available literature regarding the utilization of probiotic and synbiotics in liver transplant (LTX) recipients, reviewing efficacy in both decreasing infectious complications and immunomodulation, as well as exploring safety concerns. Data suggest that the use of probiotics containing Lactobacillus spp, either alone or in combination with prebiotics (referred to as synbiotics), may be effective in reducing infectious complications after LTX, a major contributor to graft loss, hospital length of stay, and mortality. Literature evaluating the use of probiotics to induce tolerance, reduce rejection, and prevent damage associated with ischemia-reperfusion injury is limited to animal models but compelling, as it suggests the use of probiotics may augment deleterious immune-mediated processes in this population. While the benefits of probiotics should be weighed against potential risks, these concerns are largely theoretical in the LTX recipient, with the majority of evidence extrapolated from case reports in other immunosuppressed populations. Based on available literature, it may be prudent to avoid products containing Saccharomyces sp, as these were not used in the efficacy studies, and the majority of the adverse event reporting stems from the use of products containing this organism. Further evaluation of the safety and efficacy of probiotic therapy is warranted. Studies specifically designed to elucidate the optimal product and initiation scenario and delineate safety in this population are needed to allow expanded use of this inexpensive, relatively nontoxic, and potentially beneficial therapeutic option after LTX.

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Combination of Morphologic Criteria and α‐Fetoprotein in Selection of Patients With Hepatocellular Carcinoma for Liver Transplantation Minimizes the Problem of Posttransplant Tumor Recurrence

et al. 2014

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BackgroundSerum α-fetoprotein concentration (AFP) might be a useful addition to morphologic criteria for selecting patients with hepatocellular carcinoma (HCC) for liver transplantation (LT). The aim of this study was to evaluate the role of AFP in selecting HCC patients at minimal risk of posttransplant tumor recurrence in the setting of existing criteria.MethodsThis retrospective cohort study was based on 121 HCC patients after LT performed at a single institution. AFP was evaluated as a predictor of posttransplant tumor recurrence with respect to fulfillment of the Milan, University of California, San Francisco (UCSF), and Up-to-7 criteria.ResultsThere was a nearly linear association between AFP and the risk of HCC recurrence (p < 0.001 for linear effect; p = 0.434 for nonlinear effect). AFP predicted HCC recurrence in patients (1) beyond the Milan criteria (p < 0.001; optimal cutoff 200 ng/ml); (2) within the UCSF criteria (p = 0.001; optimal cutoff 100 ng/ml) and beyond them (p = 0.015; optimal cutoff 200 ng/ml); and (3) within the Up-to-7 criteria (p = 0.001; optimal cutoff 100 ng/ml) and beyond them (p = 0.023; optimal cutoff 100 ng/ml) but not in patients within the Milan criteria (p = 0.834). Patients within either UCSF and Up-to-7 criteria with AFP level <100 ng/ml exhibited superior (100 %) 5-year recurrence-free survival—significantly higher than those within UCSF (p = 0.005) or Up-to-7 (p = 0.001) criteria with AFP levels higher than the estimated cutoffs or beyond with AFP levels less than the estimated cutoffs.ConclusionsCombining the UCSF and Up-to-7 criteria with an AFP level <100 ng/ml is associated with minimal risk of tumor recurrence. Hence, this combination might be useful for selecting HCC patients for LT.

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1000 Liver Transplantations at the Department of General, Transplant and Liver Surgery, Medical University of Warsaw - Analysis of Indications and Results

Cited by 28 publications

References 38 publications

Evolution Of The Results Of 1500 Liver Transplantations Performed In The Department Of General, Transplant And Liver Surgery Medical University Of Warsaw

Evolution Of The Results Of 1500 Liver Transplantations Performed In The Department Of General, Transplant And Liver Surgery Medical University Of Warsaw

Efficacy and Safety of Probiotics and Synbiotics in Liver Transplantation

Combination of Morphologic Criteria and α‐Fetoprotein in Selection of Patients With Hepatocellular Carcinoma for Liver Transplantation Minimizes the Problem of Posttransplant Tumor Recurrence

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