100 years of metal coordination chemistry: from Alfred Werner to anticancer metallodrugs

Abstract

Citation: Barry NPE and Sadler PJ (2014)

Definition of the Labile Capping Bond Effect in Lanthanide Complexes

“…[1] Indeed, the replacement of a coordinated water molecule by an entering ligand represents a key step in the formation of metal complexes in aqueous solutions [2] and in many redox processes. [3] The mean residence times of coordinated water molecules in aquated complexes spread over 20 orders of magnitude from ca.…”

Organometallic compounds in drug discovery: Past, present and future

“…Such compounds have found tremendous applications in catalysis or biosensing but, as surprising as it can be for certain readers of this article, also in medicine. [2][3][4][5][6][7] At this stage of the review, it is important to highlight that the famous platinum(II) anticancer drugs cisplatin, oxaliplatin and carboplatin, the antiarthritic gold(I) auranofin or the MRI agents based on gadolinium(III) are not organometallic complexes since they do not have a metalcarbon bond -they are defined as coordination complexes.…”

A Reduced Graphene Oxide‐based Electrochemical DNA Biosensor for the Detection of Interaction between Cisplatin and DNA based on Guanine and Adenine Oxidation Signals

“…One of them is its dose‐limiting toxic effects such as nausea, deafness, vomiting, loss of sensation in hands, and kidney damage, and the other one is its inactivity and/or inability against some tumor types namely leukemia, renal, gastrointestinal cancers and non‐small cell lung cancers. These limitations explain the focused attention on the search for new platinum based drugs active towards cisplatin refractory/resistant tumors .…”