100 or 30 years after Janeway or Bartter, Healthwatch helps avoid ‘flying blind’

Cornélissen, Germaine; Halberg, Franz; Bakken, Earl E.; Singh, Ram B.; Otsuka, Kuniaki; Tomlinson, Brian; Delcourt, A.; Toussaint, G.; Bathina, Srilakshmi; Schwartzkopff, Othild; Wang, Zhengrong; Tarquini, Roberto; Perfetto, Federico; Pantaleoni, Giancarlo; Józsa, R.; Delmore, Patrick; Nolley, Ellis

doi:10.1016/s0753-3322(04)80012-x

Cited by 25 publications

(20 citation statements)

References 18 publications

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“…35 Using the appropriate recording span, and a chronobiologic analysis, ACV can be detected worldwide. 36 A 7-day ABPM has greater diagnostic and prognostic benefit, due to the large number of data points gathered while subjects go through their activities of daily living, social and work routine, rest, recreation and sleep. No differences in nocturnal dipping (Figure 4) or the ambulatory arterial stiffness index was noted between the two groups in this study.…”

Section: Discussionmentioning

confidence: 99%

Prediabetes is associated with abnormal circadian blood pressure variability

et al. 2008

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Blood pressure (BP) exhibits a circadian variation characterized by a morning increase, followed by a small postprandial valley and a deeper descent during nocturnal rest. Although abnormal 24-h variability (abnormal circadian variability (ACV)) predicts adverse cardiovascular disease (CVD) outcomes, a 7-day automatic ambulatory BP monitoring (ABPM) and subsequent chronobiologic analysis of the gathered data, permits identification of consistency of any abnormal circadian variation. To test whether normal overweight healthy men and women with prediabetes differed from subjects with normoglycemia in having ACV with a 7-day ABPM. Consent for a 7-day ABPM was obtained from subjects with family history of diabetes mellitus, who were participating in the screening phase for a randomized, double blind, placebo-controlled weight loss trial in prediabetics to prevent progression to diabetes mellitus. The automatic 7-day ABPM device recorded BP and heart rate every 30 min during the day and every 60 min during the night. Normoglycemic and prediabetic subjects matched for age, sex, race, BP, BMI, waist circumference and glycemic control, differed statistically significantly only in their fasting and/or 2-h postprandial serum glucose concentrations. Chronobiologically-interpreted 7-day ABPM uncovered no abnormalities in normoglycemics, whereas prediabetics had a statistically significantly higher incidence of high mean BP (MESOR-hypertension), excessive pulse pressure and/or circadian hyper-amplitude-tension (CHAT) (Po0.001). ACV detected with 7-day ABPM may account for the enhanced CVD risk in prediabetes. These findings provide a basis for larger-scale studies to assess the predictive value of 7-day ABPM over the long term.

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Section: Discussionmentioning

confidence: 99%

Prediabetes is associated with abnormal circadian blood pressure variability

et al. 2008

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“…With this limiting qualification, BP variability in itself may be a source of useful information. Circadian hyper-amplitude-tension (CHAT), defined as an excessive circadian BP variation (BP overswinging), has been associated with a large increase in cardiovascular morbidity, cerebral ischemic events and nephropathy in particular [7][8][9] and with higher values of the left ventricular mass index, reflecting an increased risk of target organ damage [10].…”

Section: Introductionmentioning

confidence: 99%

“…An altered circadian pattern has been reported in pregnancy-induced hypertension [18] and in severe preeclamsia, where a complete reversal of the BP variation has been reported [19,20]. Single BP measurements are then only a poor indicator of the complex adaptation of the maternal circulation, while BP variability needs to be considered [7][8][9][10][11]13,[21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Circadian rhythm of maternal blood pressure and fetal growth

Maggioni¹,

Cornelissen²,

Otsuka³

et al. 2005

Biomedicine & Pharmacotherapy

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This study aimed at examining any relation between the circadian variation in blood pressure (BP) in human pregnancy and fetal growth. A prospective study included 52 pregnant women monitored during the third trimester of pregnancy. There were 33 uncomplicated pregnancies with normal fetal growth (Group 1) and 19 pregnancies complicated by intrauterine growth retardation (IUGR), confirmed at birth (Group 2). Ten women (five in each group) had pregnancy-induced hypertension. All women were hospitalized and followed a similar daily routine. BP was recorded with an automatic wearable device. Measurements were obtained every 20 min for 24 ± 1 h. BP profiles were analyzed by conventional statistical methods and by cosinor, involving the least squares fit of cosine curves with an anticipated period (24 h) to the data. BP parameters, fetal outcome, demographic and obstetric characteristics were compared between the two groups. Logistic regression and multivariate analyses were used to assess factors putatively associated with fetal outcome. The circadian amplitude of diastolic BP was found to be larger in normotensive women with IUGR. As gauged by odds ratios (OR), the circadian amplitude of diastolic BP (OR = 1.7, 95% CI: 1.1-2.8; P = 0.03) and hematocrit (OR = 1.4, 95% CI: 1.0-1.9; P = 0.04) were the only variables positively and independently associated with IUGR. In the presence of maternal hypertension, the circadian amplitude of systolic BP was negatively associated with IUGR (OR = 0.7, 95% CI: 0.5-1.0; P = 0.03). A larger circadian variation in diastolic BP, rather than a difference in the mean value of systolic or diastolic BP, was found to be statistically significantly associated with IUGR. This study adds another condition in which the circadian BP amplitude constitutes a harbinger of elevated risk, apart from an association with a shortened lifespan in the absence or presence of malignant hypertension and with an increased risk of stroke and nephropathy reported earlier.

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“…An elevated pulse pressure, a deficient heart rate variability, BP overswinging (CHAT, circadian hyper-amplitude-tension), and/or BP ecphasia (odd timing of the circadian BP variation), based on a chronomically interpreted 7-day profile, are abnormal dynamics associated with a large increase in cardiovascular disease risk. [31][32][33]. CHAT carries a risk of cerebral ischemic events and nephropathy greater than a high BP, and it is also associated with a shortened lifespan in the perspective of 28 years [34,35].…”

Section: Resultsmentioning

confidence: 99%

Plasma catecholamines: follow-up on 10-year study in health and cardiovascular disease

Prikryl¹,

Cornélissen²,

Otsuka³

et al. 2005

Biomedicine & Pharmacotherapy

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The predictive value of blood pressure (BP), heart rate (HR), and catecholamines in terms of any subsequent development of cardiovascular disease was investigated. Systolic (S) and diastolic (D) BP, HR, epinephrine (E) and norepinephrine (NE) were measured three times a year in 1980, 1984, and 1989 on 20 clinically healthy subjects, 18 patients with 'essential hypertension', and 22 patients with angina pectoris. Of the 22 patients in the latter group, 15 died during a 2-year follow-up (1990)(1991). Each individual data series was analyzed by single cosinor to assess the circannual variation. Results were summarized by population-mean cosinor for each group. Parameter tests were used to compare the circannual rhythm characteristics among the different patient groups. A circannual rhythm was invariably demonstrated on a group basis (P < 0.05). Differences in MESOR and/or circannual amplitude were found among the different groups. In particular, patients with angina pectoris who will die within the 2-year follow-up differ in terms of their E and NE from all other patient groups, a difference already detected at the beginning of the study, more than 10 years before they die. A similar separation is not achieved in terms of BP or HR.

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100 or 30 years after Janeway or Bartter, Healthwatch helps avoid ‘flying blind’

Cited by 25 publications

References 18 publications

Prediabetes is associated with abnormal circadian blood pressure variability

Prediabetes is associated with abnormal circadian blood pressure variability

Circadian rhythm of maternal blood pressure and fetal growth

Plasma catecholamines: follow-up on 10-year study in health and cardiovascular disease

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