Fate and Development of Human Vomeronasal Organ – A Microscopic Fetal Study

Ak, Vasuki; Tk, Fenn; Mn, Devi; Td, Hebzibah; Jamuna, M; Kk, Sundaram

doi:10.7860/jcdr/2016/15930.7373

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…In mice, for example, some pheromone receptors may also be present in the main olfactory epithelium (Omura and Mombaerts 2014;Kanageswaran et al 2015), possibly explaining why some apparently pheromone-mediated behavior is maintained in species lacking the vomeronasal organ. Finally, the debate on whether humans are capable of detecting pheromones is still far from resolved, as anatomical advances are ongoing Wessels et al 2014;Vasuki et al 2016), and behavioral experiments suggest that we can perceive conspecific chemosensory cues (Radulescu and Mujica-Parodi 2013;Lübke and Pause 2015;Gelstein et al 2011). Finally, the debate on whether humans are capable of detecting pheromones is still far from resolved, as anatomical advances are ongoing Wessels et al 2014;Vasuki et al 2016), and behavioral experiments suggest that we can perceive conspecific chemosensory cues (Radulescu and Mujica-Parodi 2013;Lübke and Pause 2015;Gelstein et al 2011).…”

Section: Vomeronasal Lossmentioning

confidence: 99%

“…While Trpc2 has been pseudogenized in the harbor seal and river otter (Yu et al 2010), both species retain a well-developed main olfactory system and behavioral studies indicate the presence of some olfactory social communication (van Valkenburgh et al 2011;Stoffel et al 2015). Finally, the debate on whether humans are capable of detecting pheromones is still far from resolved, as anatomical advances are ongoing Wessels et al 2014;Vasuki et al 2016), and behavioral experiments suggest that we can perceive conspecific chemosensory cues (Radulescu and Mujica-Parodi 2013;Lübke and Pause 2015;Gelstein et al 2011).…”

Section: Vomeronasal Lossmentioning

confidence: 99%

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Trpc2 pseudogenization dynamics in bats reveal ancestral vomeronasal signaling, then pervasive loss

et al. 2017

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Comparative methods are often used to infer loss or gain of complex phenotypes, but few studies take advantage of genes tightly linked with complex traits to test for shifts in the strength of selection. In mammals, vomerolfaction detects chemical cues mediating many social and reproductive behaviors and is highly conserved, but all bats exhibit degraded vomeronasal structures with the exception of two families (Phyllostomidae and Miniopteridae). These families either regained vomerolfaction after ancestral loss, or there were many independent losses after diversification from an ancestor with functional vomerolfaction. In this study, we use the Transient receptor potential cation channel 2 (Trpc2) as a molecular marker for testing the evolutionary mechanisms of loss and gain of the mammalian vomeronasal system. We sequenced Trpc2 exon 2 in over 100 bat species across 17 of 20 chiropteran families. Most families showed independent pseudogenizing mutations in Trpc2, but the reading frame was highly conserved in phyllostomids and miniopterids. Phylogeny-based simulations suggest loss of function occurred after bat families diverged, and purifying selection in two families has persisted since bats shared a common ancestor. As most bats still display pheromone-mediated behavior, they might detect pheromones through the main olfactory system without using the Trpc2 signaling mechanism.

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Section: Vomeronasal Lossmentioning

confidence: 99%

Section: Vomeronasal Lossmentioning

confidence: 99%

Trpc2 pseudogenization dynamics in bats reveal ancestral vomeronasal signaling, then pervasive loss

et al. 2017

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“…Используемые хирургические техники во многом зависят от сложившихся традиций хирургической школы, образовательного уровня врача-оториноларинголога [15,16]. По мнению ведущих ринологов мира, септумпластика является одним из наиболее востребованных, но и трудных хирургических вмешательств оториноларингологии [17,18]. В современной литературе не конкретизированы возможные варианты септумпластики при ХВЧС.…”

Section:  введениеunclassified

Варианты Септумпластики При Хроническом Верхнечелюстном Синусите

Kobakhidze¹,

Меркулова²,

Саврасова³

2021

Оториноларингология. Восточная Европа

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Цель. Изучение выбора хирургических техник септумпластики в лечении пациентов с хроническим верхнечелюстным синуситом. Материалы и методы. Выбор метода септумпластики в лечении 42 пациентов с хроническим верхнечелюстным синуситом базировался на принципе индивидуального подхода с оценкой характера, локализации смещения перегородки носа по разработанной авторами системе треугольных координат анализа 100 конусно-лучевых томограмм. Результаты. Разработанный нами анализ архитектоники перегородки носа помогает выбрать наиболее малотравматичный, щадящий вариант септумпластики с сохранением опорных структур. Выводы. Использование персонализированного подхода позволило во всех случаях смещения перегородки носа при наличии хронического верхнечелюстного синусита выполнить септумпластику с сохранением опорных элементов хрящевой и костной части перегородки носа. Purpose. The aim of our research was to study the choice of septumplasty techniques in patients with chronic maxillary sinusitis. Materials and methods. The choice of the septumplasty method in the treatment of 42 patients with chronic maxillary sinusitis was based on the principle of individual approach with assessment of the type and localization of the nasal septum deviation according to the triangular coordinate system developed by the authors based on the results of 100 cone-beam computed tomographies. Results. Analysis of the architectonics of the nasal septum developed by us helps to choose less traumatic septumplasty technique with preservation of support structures. Conclusions. Use of the personalized approach let to perform septumplasty in all cases retaining the support elements of the cartilage and bone.

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“…Reports suggest that it is more commonly found in children [ 6 , 16 - 18 ]. Some studies claim that it is present in over two-thirds of young people, with an increased incidence bilaterally, whilst other researchers suggest that it is present on both sides of the septum in almost all newborn babies [ 14 , 18 - 19 ].…”

Section: Reviewmentioning

confidence: 99%

The Human Vomeronasal (Jacobson’s) Organ: A Short Review of Current Conceptions, With an English Translation of Potiquet’s Original Text

Stoyanov¹,

Matev²,

Valchanov³

et al. 2018

Cureus

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The vomeronasal organ (VNO) is a structure located in the anteroinferior portion of the nasal septum and is part of the accessory olfactory system. The VNO, together with its associated structures, has been shown to play a role in the formation of social and sexual behavior in animals, thanks to its pheromone receptor cells and the stimulating effect on the secretion of gonadotropin-releasing hormone. The VNO was first described as a structure by the Dutch botanist and anatomist Frederik Ruysch in 1703 while dissecting a young male cadaver. This finding, however, is widely contradicted due to no elaborate descriptions being made by the Ruysch. The description of the VNO is more widely attributed to the Danish surgeon Ludwig Jacobson, with whom the VNO has been synonymized, as in 1803 he described the structure in a variety of mammals. Whilst Jacobson extensively studied prior reports of the VNO, he publicly denied its existence in humans. Following these discoveries and some contradictory statements in 1891, M. Potiquet published one of the more influential reviews on the topic. To this day, despite the first report of the organ's existence being made in a human and many articles stating its presence and supporting its function, the presence of a VNO in humans is still widely debated upon.

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Fate and Development of Human Vomeronasal Organ – A Microscopic Fetal Study

Cited by 4 publications

References 9 publications

Trpc2 pseudogenization dynamics in bats reveal ancestral vomeronasal signaling, then pervasive loss

Trpc2 pseudogenization dynamics in bats reveal ancestral vomeronasal signaling, then pervasive loss

Варианты Септумпластики При Хроническом Верхнечелюстном Синусите

The Human Vomeronasal (Jacobson’s) Organ: A Short Review of Current Conceptions, With an English Translation of Potiquet’s Original Text

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