Alternative approaches to analyzing ventilator-free days, mortality and duration of ventilation in critical care research
Ary Serpa Neto,
Michael Bailey,
Yahya Shehabi
et al.
Abstract:Objective: To discuss the strengths and limitations of ventilator-free days and to provide a comprehensive discussion of the different analytic methods for analyzing and interpreting this outcome. Methods: Using simulations, the power of different analytical methods was assessed, namely: quantile (median) regression, cumulative logistic regression, generalized pairwise comparison, conditional approach and truncated approach. Overall, 3,000 simulations of a two-arm trial with n = 300 per arm were computed usin… Show more
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