Fatty Pancreas: Disease or Finding?

Silva, Lucas de Lucena Simões e; Fernandes, Matheus Santos de Sousa; Lima, Eline Autran de; Stefano, José Tadeu; Oliveira, Conceição Maria de; Jukemura, José

doi:10.6061/clinics/2021/e2439

Cited by 21 publications

(23 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…"Fatty infiltration" occurs when there is an infiltration of adipocytes in the pancreatic tissue. The infiltration of pancreatic fat initially causes hypertrophy and hyperplasia of the pancreatic cells, resulting in clinical conditions, such as insulin resistance, beta-cell dysfunction, and diabetes mellitus type 2 [211].…”

Section: Accumulation Of Fat In Liver and Pancreasmentioning

confidence: 99%

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Verdú

Homs

Boadas-Vaello

2021

IJERPH

View full text Add to dashboard Cite

A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat body accumulation, triggering structural and functional changes in tissues, organs, and body systems. Research shows that this fat accumulation is responsible for several comorbidities, including cardiovascular, gastrointestinal, and metabolic dysfunctions, as well as pathological pain behaviors. These health concerns are related to the crosstalk between adipose tissue and body systems, leading to pathophysiological changes to the latter. To deal with these health issues, it has been suggested that physical exercise may reverse part of these obesity-related pathologies by modulating the cross talk between the adipose tissue and body systems. In this context, this review was carried out to provide knowledge about (i) the structural and functional changes in tissues, organs, and body systems from accumulation of fat in obesity, emphasizing the crosstalk between fat and body tissues; (ii) the crosstalk between fat and body tissues triggering pain; and (iii) the effects of physical exercise on body tissues and organs in obese and non-obese subjects, and their impact on pathological pain. This information may help one to better understand this crosstalk and the factors involved, and it could be useful in designing more specific training interventions (according to the nature of the comorbidity).

show abstract

Section: Accumulation Of Fat In Liver and Pancreasmentioning

confidence: 99%

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Verdú

Homs

Boadas-Vaello

2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…41 Several studies revealed a causative relationship between pancreatic steatosis with development of type 2 diabetes mellitus and pancreatic cancer. 42 inflammatory IL-10 secretion from the spleen. 5,43 Insulin resistance mobilizes free fatty acids from the adipose tissue to different organs, including the pancreas.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic steatosis is an independent risk factor for post‐transplant diabetes mellitus in kidney transplant patients

Hasbal,

Copur,

Peltek

et al. 2023

Clinical Transplantation

View full text Add to dashboard Cite

Background and AimPost‐transplant diabetes mellitus (PTDM) is associated with an increased risk of post‐transplant cardiovascular diseases, and several risk factors of PTDM have been shown in the literature. Yet, the relationship between hepatic and pancreatic steatosis with post‐transplant diabetes mellitus remains vague. We aimed to evaluate pancreatic steatosis, a novel component of metabolic syndrome, and hepatic steatosis association with post‐transplant diabetes mellitus in a single‐center retrospective cohort study conducted on kidney transplant recipients.MethodWe have performed a single‐center retrospective cohort study involving all kidney transplant recipients. We have utilized pretransplant Fibrosis‐4, nonalcoholic fatty liver disease fibrosis score, and abdominal computed tomography for the assessment of visceral steatosis status.ResultsWe have included 373 kidney transplant recipients with a mean follow‐up period of 32 months in our final analysis. Post‐transplant diabetes mellitus risk is associated with older age (p < .001), higher body‐mass index (p < .001), nonalcoholic fatty liver disease‐fibrosis score (p = .002), hepatic (p < .001) or pancreatic (p < .001) steatosis on imaging and higher pre‐transplant serum triglyceride (p = .003) and glucose levels (p = .001) after multivariate analysis.ConclusionOur study illustrates that recipients’ pancreatic steatosis is an independent predictive factor for post‐transplant diabetes mellitus including in kidney transplant patients.

show abstract

“…The term fatty pancreas was first described by Ogilvie, who reported that obese cadavers had a 17% higher pancreatic weight compared to lean cadavers. 6 The primary mechanisms of fat storage in the pancreas is due to infiltration by adipocytes and ectopic intracellular accumulation as lipid droplets. Nonalcoholic fatty pancreas disease (NAFPD) is defined as pancreatic fat accumulation associated with obesity and absence of significant alcohol consumption.…”

Section: Pancreatic Fat and Clinical Implicationsmentioning

confidence: 99%

“…The clinical consequences of pancreatic fat include impaired insulin secretion, chronic pancreatitis, possible link to pancreatic cancer, and exocrine dysfunction. 6…”

Section: Pancreatic Fat and Clinical Implicationsmentioning

confidence: 99%

See 1 more Smart Citation

Hepato-pancreatic fat-fetuin A based axis in context of diabetes and its reversal

Jayakrishnan¹

2022

Int J Adv Med

View full text Add to dashboard Cite

Recent research has focused on reversing type 2 diabetes mellitus (T2DM) via lifestyle-related approaches, including low-calorie diets. Metabolic parameters such as fat accumulation in the liver and pancreas have garnered much attention in this context. Pancreatic fat has been linked with adverse metabolic consequences including T2DM and metabolic syndrome. Obesity is the primary factor leading to ectopic fat in organs such as the liver and pancreas. This review examines the potential role of pancreatic fat in the pathogenesis of T2DM and whether it can be a potential target in reversing this chronic condition.

show abstract

Fatty Pancreas: Disease or Finding?

Cited by 21 publications

References 40 publications

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Pancreatic steatosis is an independent risk factor for post‐transplant diabetes mellitus in kidney transplant patients

Hepato-pancreatic fat-fetuin A based axis in context of diabetes and its reversal

Contact Info

Product

Resources

About