In vitro anti-inflammatory effects of vitamin D supplementation may be blurred in hemodialysis patients

Gregório, Paulo Cézar; Bucharles, Sérgio Gardano Elias; Cunha, Regiane Stafim da; Braga, Tárcio Teodoro; Almeida, Ana Clara; Henneberg, Raílson; Stinghen, Andréa Emília Marques; Barreto, Fellype Carvalho

doi:10.6061/clinics/2021/e1821

Cited by 6 publications

(6 citation statements)

References 51 publications

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“…The duration of treatment was from 1 month to 12 months. A total of 9 [17–20, 22–24, 32, 34] trials included predialysis CKD patients, 7 [21, 26–28, 30, 31, 33] trials included dialysis patients, 1 trial included predialysis CKD and dialysis patients [25] and 1 trial included kidney transplant patients [29].…”

Section: Resultsmentioning

confidence: 99%

“…Seventeen trials [17, 19–34] compared the CRP between the vitamin D group and the control group. The pooled result showed that there was no significant difference between the two groups (WMD, −0.3 mg/L; 95% CI, −0.81 to 0.22, p = 0.26, I 2 = 62%, Figure 3).…”

Section: Resultsmentioning

confidence: 99%

“…The remaining 115 full-text articles were reviewed and we excluded 98 studies. Ultimately, we included 18 trials [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34], enrolling a total of 1834 patients (Table 1). The procedure of selecting clinical studies is shown in Figure 1.…”

Section: Literature Selection and Study Characteristicsmentioning

confidence: 99%

“…The intention-to-treat approach was employed in these trials [17,19,24]. Two studies did not report concrete randomization methods [21,24]. All studies reported withdrawals.…”

Section: Quality Assessment Of Included Studiesmentioning

confidence: 99%

“…Seventeen trials [17,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] compared the CRP between the vitamin D group and the control group.…”

Section: Effects On Crp Il-6 and Tnf-αmentioning

confidence: 99%

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Effects of vitamin D on inflammatory state in patients with chronic kidney disease: A controversial issue

Zhao

Zhu

et al. 2022

Ther Apher Dial

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Background: The anti-inflammatory effect of vitamin D in patients with chronic kidney disease (CKD) remains controversial. This study aimed to conduct a meta-analysis of randomized controlled trials to assess the antiinflammatory effects of vitamin D in patients with CKD. Methods: We searched Embase, Science Citation Index, Medline, Cochrane Central Register of Controlled Trials, and Clinical Trial Registries for randomized controlled trials that comparing vitamin D with control groups for inflammatory markers in patients with CKD. Subgroup analysis was performed based on treatment duration (short-term treatment, long-term treatment), type of patients (predialysis CKD, dialysis, kidney transplant), 25(OH)D levels (25 (OH)D deficiency or normal 25(OH)D), and methods of C-reactive protein (CRP) test (standard CRP test or high-sensitivity CRP [hs-CRP] test).Results: Eighteen trials with 1834 patients were included in the present study. There were no significant differences between the vitamin D group and control group for CRP (WMD, À0.3 mg/L; 95% CI, À0.81 to 0.22, p = 0.26, I 2 = 62%), interleukin-6 (IL-6) (WMD, À1.07 pg/ml; 95% CI, À2.44 to 0.30, p = 0.12, I 2 = 52%), and tumor necrosis factor-α (TNF-α) (WMD, À0.00 pg/ml; 95% CI, À0.36 to 0.35, p = 0.99, I 2 = 0%) in patients with CKD. Subgroup analysis showed vitamin D can improve hs-CRP, but not CRP. The rest of subgroups showed that no significant differences were observed between the vitamin D group and control group based on 25(OH)D levels, treatment duration, and predialysis CKD or dialysis patients. Conclusion: This meta-analysis demonstrates that vitamin D supplementation does not have anti-inflammatory effects in CKD patients. Well-designed randomized controlled trials with large samples are required to confirm this conclusion. It is still needed to find an effective treatment for inflammatory state in CKD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Literature Selection and Study Characteristicsmentioning

confidence: 99%

“…The intention-to-treat approach was employed in these trials [17,19,24]. Two studies did not report concrete randomization methods [21,24]. All studies reported withdrawals.…”

Section: Quality Assessment Of Included Studiesmentioning

confidence: 99%

“…Seventeen trials [17,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] compared the CRP between the vitamin D group and the control group.…”

Section: Effects On Crp Il-6 and Tnf-αmentioning

confidence: 99%

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