Serum levels of NLRP3 and HMGB-1 are associated with the prognosis of patients with severe blunt abdominal trauma

Sun, Kuanxue; Xiao, Hong‐Wei

doi:10.6061/clinics/2019/e729

Cited by 5 publications

(4 citation statements)

References 27 publications

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“…23,24 The temporal pattern of HMGB-1 concentrations, means an early increase and return to background levels over time, was also detected in patients with mild/ moderate AT. 25 However, these clinical data showed also that consistently higher HMGB-1 levels in patients of severe AT were predictive for long-term lethal outcomes.…”

Section: Discussionmentioning

confidence: 89%

“…Because the liver is the most affected organ, parts of the subsequent early inflammatory response, including the high IL‐6 plasma concentrations, are probably induced intrahepatically by binding and activating of HMGB‐1 to TLR4 on Kupffer cells, which release ROS and pro‐inflammatory cytokines 23,24 . The temporal pattern of HMGB‐1 concentrations, means an early increase and return to background levels over time, was also detected in patients with mild/moderate AT 25 . However, these clinical data showed also that consistently higher HMGB‐1 levels in patients of severe AT were predictive for long‐term lethal outcomes.…”

Section: Discussionmentioning

confidence: 98%

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Temporal–spatial organ response after blast‐induced experimental blunt abdominal trauma

et al. 2021

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Abdominal trauma (AT) is of major global importance, particularly with the increased potential for civil, terroristic, and military trauma. The injury pattern and systemic consequences of blunt abdominal injuries are highly variable and frequently underestimated or even missed, and the pathomechanisms remain still poorly understood. Therefore, we investigated the temporal-spatial organ and immune response after a standardized blast-induced blunt AT. Anesthetized mice were exposed to a single blast wave centered on the epigastrium. At 2, 6, or 24 h after trauma, abdominal organ damage was assessed macroscopically, microscopically, and biochemically. A higher degree of trauma severity, determined by a reduction of the distance between the epigastrium and blast inductor, was reflected by a reduced survival rate. The hemodynamic monitoring during the first 120 min after AT revealed a decline in the mean arterial pressure within the first 80 min, whereas the heart rate remained quite stable. AT induced a systemic damage and inflammatory response, evidenced by elevated HMGB-1 and IL-6 plasma levels. The macroscopic injury pattern of the abdominal organs (while complex) was consistent, with the following frequency: liver > pancreas > spleen > left kidney > intestine > right kidney > others > lungs and was reflected by microscopic liver and pancreas damages. Plasma levels of organ dysfunction markers increased during the first 6 h after AT and subsequently declined, indicating an early, temporal impairment of the function on a multi-organ level. The established highly reproducible murine blunt AT, with time-and trauma-severity-dependent organ injury patterns, systemic inflammatory response, and impairment of various organ functions, reflects characteristics of human AT. In the future, thisThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 98%

Temporal–spatial organ response after blast‐induced experimental blunt abdominal trauma

et al. 2021

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“…Nadine Kerr and colleagues in their recent study demonstrated the potential use of serum inflammasome proteins as biomarkers of stroke [ 42 ]. Similarly, a study on the serum levels of NLRP3, published in 2019 by Kuanxue Sun and Hongwei Xia, showed elevated expression in severe blunt abdominal trauma patients and was also correlated with 6-month mortality in these patients [ 43 ]. Two more recent studies showed elevated serum NLRP3 levels associated with severity of diseases such as ulcerative colitis [ 44 ] and polyradiculoneuropathy [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Sex-Specific Signature in the Circulating NLRP3 Levels of Saudi Adults with Metabolic Syndrome

Al-Daghri

Wani

AlHarthi

et al. 2021

JCM

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Recently, inflammasomes such as NLRP3 as cytosolic pattern-recognition receptors have been implicated in the development of inflammation; however, limited investigations report the circulating levels of this protein. The objective, thus, was to investigative circulating NLRP3 levels in Saudi patients with a low-grade inflammatory disorder called metabolic syndrome (MetS). Two hundred Saudi adults aged 30–65, with or without MetS diagnosed on the basis of National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) criteria, were randomly recruited. Five MetS components were established according to the diagnostic criteria in the study subjects. Circulating levels of NLRP3 and known inflammation markers, such as tumor necrosis factor α (TNF-α), C-reactive protein (CRP) and interleukins (IL-1β and IL-18), were measured in the blood samples taken from the study subjects. Gender-based analysis showed a significant elevated circulating levels of NLRP3 in non-MetS men compared to non-MetS females (p < 0.001). Moreover, an increase in circulating levels of NLRP3 with a number of MetS components (p = 0.038) was observed only in females. A significant positive correlation of NLRP3 levels with age (r = 0.20, p = 0.04), BMI (r = 0.32, p < 0.01) and waist (r = 0.24, p = 0.02) and a significant negative correlation between NLRP3 and HDL-cholesterol (r= −0.21, p = 0.03) were also observed in females. Logistic regression analysis also yielded a sex-specific positive association of NLRP3 with MetS in females, with this association influenced mostly by central obesity and dyslipidemia components of MetS. In conclusion, this study suggests a sexual disparity in the circulating levels of NLRP3, with a trend of increasing circulating NLRP3 levels with increasing MetS components observed only in females, influenced mostly by adiposity and dyslipidemia components of MetS. Longitudinal studies with a larger sample size and investigating sex-specific hormones with NLRP3 would be needed to establish a causal relationship of NLRP3 with MetS.

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“…The current study demonstrates increased systemic HMGB-1 and extracellular histone levels 4 h and 6 h after trauma. Systemic release of HMGB-1 after trauma correlated with the injury severity as well as with the mortality of the patients [19,52]. HMGB-1 was associated with the production of inflammatory cytokines like TNF, IL-1ß and IL-6 via Toll-like receptor-2,-4 and-9 [14,53,54].…”

Section: Plos Onementioning

confidence: 95%

Structural alterations and inflammation in the heart after multiple trauma followed by reamed versus non-reamed femoral nailing

et al. 2020

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Background Approximately 30,000 patients with blunt cardiac trauma are recorded each year in the United States. Blunt cardiac injuries after trauma are associated with a longer hospital stay and a poor overall outcome. Organ damage after trauma is linked to increased systemic release of pro-inflammatory cytokines and damage-associated molecular patterns. However, the interplay between polytrauma and local cardiac injury is unclear. Additionally, the impact of surgical intervention on this process is currently unknown. This study aimed to determine local cardiac immunological and structural alterations after multiple trauma. Furthermore, the impact of the chosen fracture stabilization strategy (reamed versus nonreamed femoral nailing) on cardiac alterations was studied. Experimental approach 15 male pigs were either exposed to multiple trauma (blunt chest trauma, laparotomy, liver laceration, femur fracture and haemorrhagic shock) or sham conditions. Blood samples as well as cardiac tissue were analysed 4 h and 6 h after trauma. Additionally, murine HL-1 cells were exposed to a defined polytrauma-cocktail, mimicking the pro-inflammatory conditions after multiple trauma in vitro. Results After multiple trauma, cardiac structural changes were observed in the left ventricle. More specifically, alterations in the alpha-actinin and desmin protein expression were found. Cardiac structural alterations were accompanied by enhanced local nitrosative stress, increased local inflammation and elevated systemic levels of the high-mobility group box 1

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Serum levels of NLRP3 and HMGB-1 are associated with the prognosis of patients with severe blunt abdominal trauma

Cited by 5 publications

References 27 publications

Temporal–spatial organ response after blast‐induced experimental blunt abdominal trauma

Temporal–spatial organ response after blast‐induced experimental blunt abdominal trauma

Sex-Specific Signature in the Circulating NLRP3 Levels of Saudi Adults with Metabolic Syndrome

Structural alterations and inflammation in the heart after multiple trauma followed by reamed versus non-reamed femoral nailing

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