The diagnostic value of narrow-band imaging for early and invasive lung cancer: a meta-analysis

Abstract

This study aimed to compare the ability of narrow-band imaging to detect early and invasive lung cancer with that of conventional pathological analysis and white-light bronchoscopy. We searched the PubMed, EMBASE, Sinomed, and China National Knowledge Infrastructure databases for relevant studies. Meta-disc software was used to perform data analysis, meta-regression analysis, sensitivity analysis, and heterogeneity testing, and STATA software was used to determine if publication bias was present, as well as to calculate the relative risks for the sensitivity and specificity of narrow-band imaging vs those of white-light bronchoscopy for the detection of early and invasive lung cancer. A random-effects model was used to assess the diagnostic efficacy of the above modalities in cases in which a high degree of between-study heterogeneity was noted with respect to their diagnostic efficacies. The database search identified six studies including 578 patients. The pooled sensitivity and specificity of narrow-band imaging were 86% (95% confidence interval: 83–88%) and 81% (95% confidence interval: 77–84%), respectively, and the pooled sensitivity and specificity of white-light bronchoscopy were 70% (95% confidence interval: 66–74%) and 66% (95% confidence interval: 62–70%), respectively. The pooled relative risks for the sensitivity and specificity of narrow-band imaging vs the sensitivity and specificity of white-light bronchoscopy for the detection of early and invasive lung cancer were 1.33 (95% confidence interval: 1.07–1.67) and 1.09 (95% confidence interval: 0.84–1.42), respectively, and sensitivity analysis showed that narrow-band imaging exhibited good diagnostic efficacy with respect to detecting early and invasive lung cancer and that the results of the study were stable. Narrow-band imaging was superior to white light bronchoscopy with respect to detecting early and invasive lung cancer; however, the specificities of the two modalities did not differ significantly.

Role of I-scan technique in screening for lung cancer in smokers with positive sputum cytology

“…For another commonly addressed bronchoscopic technique in the field of lung cancer screening which is NBI, a relatively recent meta-analysis published in 2017 and based on four studies found that the pooled sensitivity of NBI to detect lung cancer was 91% (both CIS and invasive lesions) compared to a pooled sensitivity of WLB of 70% [44][45][46][47][48]. In one of these four studies, Herth et al compared AFB and NBI in the detection of intraepithelial neoplasia.…”

Cập Nhật Các Phương Pháp Chẩn Đoán Sớm Ung Thư Phổi

“…Đồng thời, nó cũng có thể đánh giá sự xâm lấn của khối u và hướng dẫn chiến lược phẫu thuật điều trị trong các tổn thương đường thở trung tâm. Tổng hợp kết quả từ 6 nghiên cứu, Zhu J. và CS đã đưa ra bảng tổng kết đánh giá độ nhạy và độ đặc hiệu của nội soi dải sáng hẹp trong chẩn đoán sớm UTP (Bảng 4) [13].…”

Bronchoscopic diagnosis and treatment of endobronchial carcinoid: case report and review of the literature

“…FIGURE 3 Follow-up at 2 years: a) computed tomography scan and b) bronchoscopy with narrow band imaging (NBI) to check for local recurrence. NBI uses a unique filter to select light wavelengths that are preferentially absorbed by haemoglobin, thereby permitting superior microvasculature detection compared with conventional bronchoscopy [62]. As angiogenesis occurs preferentially in dysplastic or neoplastic lesions, NBI aids in early assessment of local recurrence.…”