The Effect of FRAX on the Prediction of Osteoporotic Fractures in Urban Middle-aged and Elderly Healthy Chinese Adults

Wang, Jun; Wang, Xuejun; Fang, Zhen; Lu, Nanjia; Han, Liyuan

doi:10.6061/clinics/2017(05)06

Cited by 9 publications

(6 citation statements)

References 18 publications

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“…Previous fractures accounted for 20.21% of the total sample (n = 171), and 5.32% of the subjects had a family history of osteoporosis (n = 45). At present, smokers are accountable for 47.04% of the study population (n = 398), and 42.79% of people drink more than 30 g of alcohol per day (n = 362) [ 22 ]. There were significant differences in weight, height, BMI, previous fracture, BMD, family history, current smokers and alcohol over 30 g/d between the fracture group and the non-fracture group ( p < 0.05).…”

Section: Resultsmentioning

confidence: 99%

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Beijing Friendship Hospital Osteoporosis Self-Assessment Tool for Elderly Male (BFH-OSTM) vs Fracture Risk Assessment Tool (FRAX) for identifying painful new osteoporotic vertebral fractures in older Chinese men: a cross-sectional study

Lin

2021

BMC Musculoskelet Disord

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Background To compare the validation of four tools for identifying painful new osteoporotic vertebral compression fractures (PNOVCFs) in older Chinese men: bone mineral density (BMD), Asian osteoporosis self-assessment tool (OSTA), World Health Organization fracture risk assessment tool (FRAX) (without BMD) and Beijing Friendship Hospital Osteoporosis Self-Assessment Tool (BFH-OSTM). Methods A cross sectional study was conducted from 2013 to 2019. A total of 846 men aged ≥50 were included and were divided into two groups: Fracture Group (patients with PNOVCFs underwent percutaneous vertebroplasty surgery) and Non-Fracture Group (community dwelled subjects for healthy examination). All subjects accepted a dual-energy X-ray BMD test and a structured questionnaire. The results of BMD, OSTA, FRAX and BFH-OSTM scores were assessed and receiver-operating characteristic (ROC) curves were generated to compare the validity of four tools for identifying PNOVCFs. Optimal cutoff points, sensitivity, specificity, and areas under the ROC curves (AUCs) were determined. Results There were significant differences including BMD T score (femoral neck, total hip and L1-L4), OSTA, FRAX and BFH-OSTM scores between Fracture group and Non-fracture group. Compared to BMD and OSTA, BFH-OSTM and FRAX had better predictive value, the sensitivity, specificity and AUC value are 0.841, 81.29%, 70.67% and 0.796, 74.85%, 78.52%, respectively. Compared with FRAX, the BFH-OSTM has a better AUC value. Conclusions Both BFH-OSTM and FRAX can be used to identify POVCFs, However, BFH-OSTM model may be a more simple and effective tool to identify the risk of POVCFs in Chinese elderly men.

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Section: Resultsmentioning

confidence: 99%

“…FRAX is a computer algorithm based on the use of clinical risk factors ( http://www.sheffield.ac.uk/FRAX ) and is also the most widely validated and widely used tool for male and female fracture risk assessment [ 22 ]. It combines the risk of fracture and the risk of death, and constructs four models to calculate the probability of fracture.…”

Section: Methodsmentioning

confidence: 99%

Beijing Friendship Hospital Osteoporosis Self-Assessment Tool for Elderly Male (BFH-OSTM) vs Fracture Risk Assessment Tool (FRAX) for identifying painful new osteoporotic vertebral fractures in older Chinese men: a cross-sectional study

Lin

2021

BMC Musculoskelet Disord

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“…Body mass index (BMI), an indicator compounded of weight and height, showed negative association with FRAX-based fracture probabilities in the previous studies. This association was especially significant in subjects with a BMI less than 19 kg/m 2 , while for subjects with a BMI greater than 19 kg/m 2 , the fracture risk remained relatively stable [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Fracture Risk through Radiofrequency Echographic Multi Spectrometry (REMS) based Bone Mineral Density

Kirilova¹

2019

OROAJ

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Introduction: Fracture Risk Assessment Tool (FRAX) was developed by the World Health Organization (WHO) to be applicable to both postmenopausal women and men aged 40 to 90 years. The current National Osteoporosis Foundation Guide recommends treating patients with FRAX 10-year risk scores of > or = 3% for hip fracture or > or = 20% for major osteoporotic fracture, to reduce their fracture risk.Methods: 189 postmenopausal women with mean age 60 years ± 9 standard deviations (SD), (range 40-86) were included in the study. Women were divided in 2 fracture risk groups: 1st -with FRAX score for major osteoporotic fracture below 20% and for hip fracture below 3%, and 2nd -with FRAX score for major osteoporotic fracture ≥ 20% and for hip fractures ≥3%. Descriptive statistical analysis was used to describe the patients' characteristics in both groups. Independent sample t-test was used to assess the significant association between the quantitative variables and chi-square test -for the qualitative variables.Results: 77.8% of the women (147/189) had FRAX score for major osteoporotic fracture below 20% and 22.2% (42/189) with FRAX score ≥20%. 62.4% (118/189) of the women had FRAX score for hip fracture below 3% and 37.6% (71/189) had FRAX score ≥3%. Women with FRAX score for major osteoporotic fracture ≥20% and FRAX score for hip fracture ≥3% were significantly older (p=0.000), had significantly lower weight (p=0.000), height (p=0.000) and femoral neck BMD (p=0.000) compared to those with FRAX score for major osteoporotic fracture below 20% and FRAX score for hip fracture below 3%. Conclusion:Postmenopausal women at older ages, with low femoral neck BMD, low weight and height, who had previous fractures, have diagnosis of Rheumatoid arthritis (RA) and use corticosteroids are at the highest risk of FRAX for major osteoporotic fractures ≥20% and for hip fractures ≥3%.

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“…These include age, sex, race, height, weight, body mass index, prior fragility fracture, smoking, excess alcohol, family history of hip fracture, rheumatoid arthritis, and the use of oral glucocorticoids. [ 7 ] These risk factors in conjunction with BMD can be integrated to provide estimates of fracture probability using web-based algorithm design called FRAX (Fracture Risk Assessment Tool). FRAX calculates the 10-year probability of a major osteoporotic-related fracture in the proximal part of the humerus, the wrist, or the hip or spine.…”

Section: Methodsmentioning

confidence: 99%

Pharmacological and non-pharmacological means for prevention of fractures among elderly

Fares¹

2018

Int J Prev Med

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Fractures are major cause of morbidity, mortality, and healthcare and social services expenditure in elderly. Fractures often have multifactorial etiologies and the condition emerges due to the interaction between the different predisposing and precipitating factors. One of the most common causes leading to fractures after minimal trauma in older people is osteoporosis. The objective of this article is to describe the clinical concept and summarize the evidence and to explain the future directions for research, focusing on specific issues related to prevent fracture in the elderly. This study reviewed the scientific literature addressing strategies for primary and secondaryprevention of fractures among elderly in the context of pharmacological and non-pharmacological means. A growing body of scientific evidence supports the use of both non-pharmacological and pharmacological interventions for the prevention of fracture. Research on these interventions has yielded positive outcomes in fracture rates. The bisphosphonates and vitamin D and calcium suppliments are the preferred therapy for prevention of osteoporotic fractures. Weight-bearing exercise and reducing home hazards have beneficial effects in reducing the incidence of falls and consequently reduce fractures. Prevention of fractures in elderly consists of therapy and prevention of osteoporosis, fall prevention, and using injury-site protection by high-risk elderly patients. Special consideration needs to be taken to reduce home hazard, and falls prevention education can be recommended to the elderly with history of fall or mobility limitations. Future research to prevent fractures in elderly population should not only concentrate on improving bone density and strength but also need to be focused on falls reduction strategies.

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The Effect of FRAX on the Prediction of Osteoporotic Fractures in Urban Middle-aged and Elderly Healthy Chinese Adults

Cited by 9 publications

References 18 publications

Beijing Friendship Hospital Osteoporosis Self-Assessment Tool for Elderly Male (BFH-OSTM) vs Fracture Risk Assessment Tool (FRAX) for identifying painful new osteoporotic vertebral fractures in older Chinese men: a cross-sectional study

Beijing Friendship Hospital Osteoporosis Self-Assessment Tool for Elderly Male (BFH-OSTM) vs Fracture Risk Assessment Tool (FRAX) for identifying painful new osteoporotic vertebral fractures in older Chinese men: a cross-sectional study

Assessment of Fracture Risk through Radiofrequency Echographic Multi Spectrometry (REMS) based Bone Mineral Density

Pharmacological and non-pharmacological means for prevention of fractures among elderly

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