First Latin uterine transplantation: we can do it!

Júnior, José Maria Soares; Ejzenberg, Dani; Andraus, Wellington; D’Albuquerque, Luiz Augusto Carneiro; Baracat, Edmund Chada

doi:10.6061/clinics/2016(11)01

Cited by 14 publications

(6 citation statements)

References 14 publications

(18 reference statements)

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“…Several UTx have also been published in the press, notably the first UTx with a live donor performed in France (March 2019, Paris). All procedures published through scientific publications are described in Table 2 [2,3,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61]. Ten failures of transplantations have been reported in publications: one in the Saudi Arabia [2]; two by the Swedish team of Pr.…”

Section: Experimental and Clinical Studiesmentioning

confidence: 99%

“…There are two types of donors for UTx: living donors and brain-dead donors. Six teams work only with living donors [2,3,50,56,58] (Saudi Arabia, Sweden, China, Germany, Serbia and India) and three works solely with brain-dead donors [48,52,55] (Turkey, Cleveland and Brazil). There are also two teams working with both types of donors [61,62] (Dallas and Czech Republic).…”

Section: Experimental and Clinical Studiesmentioning

confidence: 99%

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The Key Role of Warm and Cold Ischemia in Uterus Transplantation: A Review

Tardieu

Dion

Lavoué

et al. 2019

JCM

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Introduction: Uterus transplantation (UTx) is a promising treatment for uterine infertility that has resulted in several births since 2014. Ischemia is a key step in organ transplantation because it may lead to changes jeopardizing graft viability. Method: We performed a systematic review of animal and human studies relating to uterine ischemia. Results: We retained 64 studies published since 2000. There were 35 studies in animals, 24 in humans, and five literature reviews. Modest preliminary results in large animals and humans are limited but encouraging. In small animals, pregnancies have been reported to occur after 24 h of cold ischemia (CI). In ewes, uterine contractions have been detected after 24 h of CI. Furthermore, it has been shown in animals that uterine tolerance to CI and to warm ischemia (WI) can be increased by pharmacological products. In women, mean CI time in studies of births from uteri obtained from live donors was between 2 h 47 min and 6 h 20 min from a deceased donor; with only one birth in this case. Muscle contractions have also been demonstrated in myometrial samples from women, after six or more hours of CI. Conclusion: The uterus seems to be able to tolerate a prolonged period of CI, of at least six hours. Studies of the ischemia tolerance of the uterus and ways to improve it are essential for the development of UTx, particularly for procedures using grafts from deceased donors.

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Section: Experimental and Clinical Studiesmentioning

confidence: 99%

Section: Experimental and Clinical Studiesmentioning

confidence: 99%

The Key Role of Warm and Cold Ischemia in Uterus Transplantation: A Review

Tardieu

Dion

Lavoué

et al. 2019

JCM

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“…Седьмой случай ТМ от мертвого донора выполнен в Сан-Паулу (Бразилия) в сентябре 2016 г., операция прошла успешно, у реципиента менструальная функция возобновилась в течение 2 мес после операции [24]. Беременность наступила после первой попытки переноса эмбриона, в декабре 2017 г. родился здоровый ребенок (неопубликованные данные W. Andraus).…”

Section: тм от мертвого донораunclassified

Transplantatiom of the uterus - current state of the problem in the world (literature review)

Brännström¹,

Курцер²,

Polstyanoy³

et al. 2019

Probl. reprod.

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Цель данного обзора-собрать воедино актуальные данные, опубликованные по проблеме трансплантации матки (ТМ) у человека, а также осветить хирургические и технические особенности данной технологии. За последние 5 лет отмечается значительный рост количества публикаций, посвященных проблематике ТМ. Концепция ТМ как эффективного и безопасного метода лечения абсолютного бесплодия маточного генеза подтверждена первыми публикациями о рождении здоровых детей после этого вмешательства в Швеции в сентябре 2014 г. С тех пор концепция неоднократно доказывала свою успешность, опубликованы данные о рождении детей после ТМ в Швеции, Бразилии, Италии и США. На сегодняшний день ТМ с живым донором и трупная трансплантация доказали свою эффективность в разных странах мира. Однако ТМ не является рутинной операцией и все еще находится на стадии эксперимента.

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“…It may assist women with no possibility of becoming pregnant, such as those with congenital agenesis of the uterus, massive destruction of the endometrium after infected abortion, or those hysterectomized. 4 However, we still have much to improve in this field before its consolidation as a concrete alternative for these women.…”

mentioning

confidence: 99%

“…These are the major challenges to the existing technique. 4,10,11 In the current context, for the performance of the technique in individuals of male biological sex, great modifications and improvements would be necessary. Anatomical and physiological differences have to be overcome, such as the shape of the male pelvis, which is narrower and has a smaller opening than the female pelvis, and that could hinder the implantation and growth of the uterus during pregnancy.…”

mentioning

confidence: 99%

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2017

Rev Bras Ginecol Obstet

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First Latin uterine transplantation: we can do it!

Cited by 14 publications

References 14 publications

The Key Role of Warm and Cold Ischemia in Uterus Transplantation: A Review

The Key Role of Warm and Cold Ischemia in Uterus Transplantation: A Review

Transplantatiom of the uterus - current state of the problem in the world (literature review)

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