Expression of estrogen and progesterone receptors in astrocytomas: a literature review

Tavares, Cléciton Braga; Braga, Francisca das Chagas Sheyla Almeida Gomes; Costa‐Silva, Danylo Rafhael; Escórcio-Dourado, Carla Solange; Borges, Umbelina Soares; Conde-Júnior, Airton Mendes; Barros-Oliveira, Maria da Conceição; Sousa, Emerson Brandão; Barros, Lorena da Rocha; Martins, Luana Mota; Facina, Gil; da-Silva, Benedito B.

doi:10.6061/clinics/2016(08)12

Cited by 27 publications

(29 citation statements)

References 35 publications

(88 reference statements)

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“…A negative correlation was shown between ER expression and grade of astrocytoma malignancy, which is in agreement with the literature. ER is mainly expressed in normal astrocytic cells and low-grade gliomas, promoting neuroprotective role 8,9,11,[16][17][18] .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of estrogen receptor expression in low-grade and high-grade astrocytomas

Tavares

Braga

Sousa

et al. 2018

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: This study aims to compare estrogen receptor expression between low and high-grade astrocytomas. METHOD: A study using paraffin blocks of glial tumors from the Anatomy Pathology archives of São Marcos Hospital was carried out and began after approval by the Review Board of the Federal University of Piaui. Specimens were histochemically marked with an anti-ER alpha antibody. Brown-stained nuclei were considered positive, regardless of reaction intensity. Data were statistically analyzed using the Mann-Whitney test and Spearman's correlation. Statistical significance was established at p<0.05. RESULTS: The mean percentage of nuclei stained with anti-ER alpha in low-and high-grade astrocytomas was 0.04 and zero, respectively, while Spearman's correlation showed a strong negative association between low and high-grade tumors (p<0.001) and (r= −0.67), respectively. CONCLUSION: In the current study, estrogen receptor expression was positive only in low-grade astrocytomas and nil in high-grade astrocytomas, showing that ER expression declines with the grade of tumor malignancy.

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Section: Discussionmentioning

confidence: 99%

Evaluation of estrogen receptor expression in low-grade and high-grade astrocytomas

Tavares

Braga

Sousa

et al. 2018

Rev. Assoc. Med. Bras.

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“…Besides their role in normal reproductive development, sex steroids may also play a role in the development and progression of several cancers (Marceau et al2015). Estrogens are steroid hormones that exert important effects on the reproductive and gastrointestinal systems, mammary glands, skeletal and immune systems, and even the central nervous system (Tavares et al 2016). Diethylstilbestrol (DES) is a synthetic form of the female hormone estrogen.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Hormonal Treatment on Cell Viability in F98 Cell Line

Balkan

Kısmalı

Cengiz

et al. 2020

Van Veterinary Journal

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“…According to some scientific reports the VEGF expression in tumor cells of diffuse astrocytic neoplasms is a poor prognostic factor [6,9,13]. Glial tumor cells rarely show the progesterone receptor (RP) expression in cytoplasm, nuclei and also in endothelium of blood vessels [11,25]. But the causes of this phenomenon are still unclear and insufficiently studied.…”

Section: Introductionmentioning

confidence: 99%

Proliferative features of diffuse astrocytic tumors Grade III-IV and their impact on the prognosis

2018

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Anaplastic astrocytoma and glioblastoma are malignant brain tumors with a poor prognosis. The aim of our study was the complex investigation of the factors, those influence their aggressive behavior and proliferation (Ki-67, EGFR, MMP-9, PR, р53, vascular network formation), and the evaluation of their prognostic impact. These data could be used for optimization of target therapy in different groups of patients with diffuse astrocytic tumors Grade III-IV. Our study included 30 patients who were put through brain surgery for the first time and were divided into two equal groups: 15 patients who experienced a recurrence within 1 year after the surgery (1st group) and 15 patients without recurrence within 1 year after the surgery (2nd group). Postoperative tumor materials were obtained in formalin-fixed, paraffin-embedded blocks. In addition, we investigated the case histories of these patients. The expression of Ki-67, EGFR, MMP-9, PR, р53, VEGF, and CD34 was evaluated with immunohistochemical testing. Chi-squared test, Mann-Whitney U and Kruskal-Wallis H tests were performed for comparison of quantitative parameters between groups. Spearman’s rank correlation coefficient was used for the measure of rank correlation between quantitative variables. Results of our study showed, that there was a tendency (Uemp=75,00; р>0.05) to higher proliferative index in the 1st group (18,29±3,44) compared to the 2nd group (16,57±3,09). EGFR expression was significantly higher in the 1st group (Uemp=70.50; p<0.05). Moreover, the higher EGFR expression was associated with higher MMP-9 expression (Uemp=7.500; p<0.01) and lower p53 expression (rs= –0.62, p<0.001). The higher MMP-9 expression was also associated with higher vascularization index (MVD(VEGF)/MVD(CD34)) (rs=0.43; p<0.05). Our data confirm the close connections of different factors of tumor aggressiveness and the presence of molecule-biological discrepancy in homogenous histologically, but heterogenous prognostically groups of tumors. This evidence may be used in future for better-personalized therapy of patients with diffuse astrocytic tumors Grade III-IV.

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Expression of estrogen and progesterone receptors in astrocytomas: a literature review

Cited by 27 publications

References 35 publications

Evaluation of estrogen receptor expression in low-grade and high-grade astrocytomas

Evaluation of estrogen receptor expression in low-grade and high-grade astrocytomas

The Effect of Hormonal Treatment on Cell Viability in F98 Cell Line

Proliferative features of diffuse astrocytic tumors Grade III-IV and their impact on the prognosis

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