“…Especially in these situations, immunohistochemistry may also help in distinguishing between HCC and other adenocarcinomas (84) . HCC subtypes, some of which are already well characterized in their morphological and molecular profiles, have been described, including FLC (87) ; scirrhous hepatocellular carcinoma (88) ; steatohepatic HCC (89) ; HCC with lymphoid stroma, clear-cell variant of HCC and sarcomatous HCC (90) . On the other hand, the identification of molecular profiles by gene expression, DNA sequencing or RNA sequencing techniques or even combined approaches has brought new proposals for the classification of HCC based on genetics, highlighting, in summary, two major types:…”