The prevalence of adenoviral conjunctivitis at the Clinical Hospital of the State University of Campinas, Brazil

Pinto, Roberto Damian Pacheco; Lira, Rodrigo Pessoa Cavalcanti; Arieta, Carlos Eduardo Leite; Castro, Rosane Silvestre de; Bonon, Sandra Helena Alves

doi:10.6061/clinics/2015(11)06

Cited by 20 publications

(15 citation statements)

References 26 publications

(20 reference statements)

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“…Viruses are associated with up to 80% of all prevalence of acute conjunctivitis 16-20 . 65 to 90% of cases of viral conjunctivitis are caused by adenoviruses, and it produces two common clinical symptoms related to viral conjunctivitis: pharyngoconjunctival fever (high fever, pharyngitis and bilateral conjunctivitis) and keratoconjunctivitis (lymphadenopathy). In another report from Southeastern Brazil, in Sao Paulo, the authors found a prevalence of 59.0% with acute conjunctivitis associated with adenovirus diagnosed by PCR 21 . In addition, in Northeastern Brazil, in Fortaleza, a study assessing 24 patients demonstrated that 12 (50%) tested positively for viral infection 22 .…”

Section: ■ Discussionmentioning

confidence: 92%

Comparative study on the efficacy of non-steroidal, steroid and non-use of anti-inflammatory in the treatment of acute epidemic conjunctivitis

Santiago¹,

Silva

Azevedo³

et al. 2019

Acta Cir. Bras.

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Section: ■ Discussionmentioning

confidence: 92%

Comparative study on the efficacy of non-steroidal, steroid and non-use of anti-inflammatory in the treatment of acute epidemic conjunctivitis

Santiago¹,

Silva

Azevedo³

et al. 2019

Acta Cir. Bras.

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“…Less common causes include herpetic viruses, picornaviruses, Epstein-Barr virus, influenza viruses, paramyxovirus and poxviruses. Results from studies conducted in Brazil showed that adenoviruses were involved in 59% of all viral cases of conjunctivitis in that country 26 , whereas worldwide, adenoviruses have been found to be involved in 15% to 70% of all cases of infectious conjunctivitis…”

Section: IIImentioning

confidence: 99%

Molecular Detection of Adenovirus type 2 among Conjunctivitis Patients in Khartoum State- Sudan

Shambal¹

2018

IJRASET

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Background: Adenoviruses are a group of viruses that can infect the membranes (tissue linings) of the respiratory tract, eyes, intestines, and urinary tract. Diagnosis of conjunctivitis and differentiation between bacterial, viral, and noninfectious conjunctivitis are usually clinical. PCR and other rapid, office-based immunodiagnostic tests can be useful especially when the inflammation is severer. Objective: This study aimed to detect adenovirus among conjunctivitis infected patients to figure out the possibility of using PCR technique to achieve that goal. Methods: By using PCR for DNA products of 45 conjunctivitis swabs, to detect adenovirus type 2. The Results: Only one sample gave a positive result out of 45 samples detected (2.2%) Conclusion: It seems to be no adenovirus spreading enough among patients causing their eye illness, therefore other causative agents for conjunctivitis may be existence, as in Sudan most of the year the climate not suitable for adenovirus survival as it lives in cold and wet environments unlike what above local one. However, if any signs suggest bacterial conjunctivitis (eg, purulent discharge), cultures or other studies may be useful. The prevalence of adenoviral conjunctivitis in the study population was lower than the prevalence in other regions of the world.

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“…In recent years, viral conjunctivitis is the most common, followed by bacterial conjunctivitis [3,4], and adenovirus is one of the main causes of viral conjunctivitis. Human adenoviruses (HAdV) are non-enveloped, a doublestranded DNA virus [5][6][7][8][9][10][11] with icosahedral capsids in the family Adenoviridae. The viral particles roughly 65 to 80nm in size consist of protein capsid, core protein and DNA.…”

Section: Introductionmentioning

confidence: 99%

An Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type 8 in Primary School, Southwest China

Zhou

et al. 2019

Preprint

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Background Two outbreaks of acute conjunctivitis occurred successively with an interval of five days in two boarding primary schools in Weixi Lisu autonomous county, Diqing Tibetan autonomous prefecture, Yunnan. The aims of this study were to determine the intensity of and characteristics of outbreaks, as well as the clinical manifestation of patients and risk factors infected, and the pathogen causing two outbreaks. Methods An outbreak investigation and a case-control study were conducted in two primary schools. The relevant specimens were collected by case definition, Next generation sequencing was adopted to identify the pathogen, and the epidemiological investigation method was used to analyze the related epidemiological characteristics such as risk factors. The phylogenetic tree was constructed by MEGA 7.0. Results A total of 331 acute conjunctivitis cases, as acute hemorrhagic conjunctivitis probable cases, were reported in two schools and the attack rates were 30.59% (171/559, 95%CI: 26.76-34.42) and 20.41% (160/784, 95%CI: 17.58-23.24), respectively. Cases occurred in all grades and classes in both schools, and only one staff was ill in each school. Epidemic situations lasted for 54 days and 45 days, respectively. Epidemic curve of two breaks appearing two peaks indicated the mode of person-to-person transmission for two outbreaks. The patients had typical manifestations of epidemic keratoconjunctivitis (EKC) such as acute onset, follicular hyperplasia, pseudomembrane formation, preauricular lymphadenopathy, corneal involvement and blurred vision, and the longer course of the disease (average 9.40 days, longest 23 days and shortest 7 days). The risk factor in infection was close contact with the patient or personal items contaminated by the patient. The pathogen caused the outbreaks is HAdV-8. The virus was highly homologous to the 2016 HAdV-8 strain in Tibet, China. Conclusions This study strongly suggests that HAdV-8 could lead to serious consequences. This is the second report of a HAdV-8 associated EKC outbreak in mainland of China. Tibetan HAdV-8 might be circulating in southwest China, it is necessary to monitor the pathogen of acute conjunctivitis in this area.

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The prevalence of adenoviral conjunctivitis at the Clinical Hospital of the State University of Campinas, Brazil

Cited by 20 publications

References 26 publications

Comparative study on the efficacy of non-steroidal, steroid and non-use of anti-inflammatory in the treatment of acute epidemic conjunctivitis

Comparative study on the efficacy of non-steroidal, steroid and non-use of anti-inflammatory in the treatment of acute epidemic conjunctivitis

Molecular Detection of Adenovirus type 2 among Conjunctivitis Patients in Khartoum State- Sudan

An Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type 8 in Primary School, Southwest China

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