Objective: (1) To identify differences in driving simulator braking time response between paraplegic and able-bodied drivers (2) To determine the contributions of age, driving experience, length of disability, handgrip strength and, neuropsychological tests, as selected factors, to driving simulator braking time response of drivers with paraplegia. Design: Two groups of male able-bodied and paraplegic drivers had their braking time response evaluated in an automatic transmission car simulator. Able-bodied drivers were tested with conventional controls and paraplegic drivers used hand controls. Drivers with paraplegia performed simple, choice and go-no-go reaction time tests as neuropsychological evaluation. Student's t test compared results of driving simulator braking time response between groups. Persons' correlation verified the association between driving simulator braking time responses and selected variables of the drivers with paraplegia. Subjects: Able-bodied drivers (n=20 mean age 38.0±5.8) and paraplegic drivers (n=20 mean age 38.1±3.6) with valid driver license accepted to be part of this study. Results: Differences of simulator braking time response between groups were not statistically significant (able-bodied=0.90 seconds; paraplegic drivers 0.92 seconds, p>0.05). Driving experience significantly correlates with braking time response of the drivers with paraplegia (r=-58, p=0.009). Linear regression analyses indicated that years of education and driving experience (explanatory variables) explained 60.2% of driving simulator braking time response for the drivers with paraplegia. Conclusion: Driving experience, years of education and MOCA neuropsychological test were predictors variables of driving simulator braking time for paraplegic drivers.