Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: A ten-year retrospective study

Xiong, Ji; Wang, Jun; Huang, Juan; Sun, Wenjing; Chen, Dongfeng

doi:10.6061/clinics/2015(08)06

Cited by 23 publications

(14 citation statements)

References 30 publications

(38 reference statements)

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“…Studies on NAFLD related cirrhosis and HCC in China are limited. Sporadic studies have reported NASH‐related LC over the past two decades, with an average proportion of NASH‐related LC in China of 1.9% in the early 2000s that increased to 3.2%‐5% in the 2010s . There are no data regarding the contribution of NAFLD to HCC or liver transplantation.…”

Section: Resultsmentioning

confidence: 99%

Epidemiological Features of NAFLD From 1999 to 2018 in China

et al. 2020

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With dramatic changes in lifestyles over the last 20 years, nonalcoholic fatty liver disease (NaFlD) has become the most prevalent liver disorder in China but has not received sufficient attention. NaFlD-related advanced liver disease and its mortality along with its overall disease burden are expected to increase substantially. there is thus an imperative need to clarify the epidemiological features of NaFlD to guide a holistic approach to management. We summarize eight epidemiological features of NaFlD in China over the past two decades using systematic review and meta-analysis methodology. our data reveal a rapid growth in the NaFlD population, especially among younger individuals. Importantly, there is a strong ethnic difference in body mass index (BMI) and genetic risk of NaFlD compared with the US population. the etiology of advanced liver disease and its complications (e.g., hepatocellular carcinoma) has been altered because of a Westernized lifestyle and the implementation of effective vaccination strategies against viral hepatitis. Regional epidemiological patterns of NaFlD indicate that economics, environment, and lifestyle are critical factors in disease progression. the analysis also indicates that a large number of patients remain undiagnosed and untreated because of the inadequacy of diagnostic tools and the absence of effective pharmacologic therapies. given the burden of NaFlD, future policy and research efforts need to address knowledge gaps to mitigate the risk burden.

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Section: Resultsmentioning

confidence: 99%

Epidemiological Features of NAFLD From 1999 to 2018 in China

et al. 2020

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“…I N CHINA, PATIENTS withhepatitis B liver cirrhosis currently constitute an integral proportion of cirrhosis patients. 1 Hepatitis B liver cirrhosis is a long-term chronic disease, accompanied by complications such as ascites, esophageal variceal bleeding, and hepatic coma in the course of disease progression; moreover, patients with hepatitis B liver cirrhosis are at a high risk for liver cancer. 2,3 Therefore, the patients may suffer from issues such as long-term psychological stress, pain, and economic burden.…”

Section: Introductionmentioning

confidence: 99%

Study of the sleep quality and psychological state of patients with hepatitis B liver cirrhosis

Xiao

Han

et al. 2017

Hepatology Research

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“…In China, the number of patients newly diagnosed with liver cirrhosis is about 300,000 per year, and the number of deaths due to cirrhosis is as high as 110,000 per year [21][22][23] . Among the causes of death, bleeding due to esophageal varices is the most common [24,25] .…”

Section: Discussionmentioning

confidence: 99%

New formula for predicting standard liver and spleen volumes in Chinese adults

Yang¹,

Zhao²,

Tantai³

et al. 2019

Preprint

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BACKGROUNDThe liver volume and spleen volum are useful index for cirrhosis patients with esphageal varices. But the calculation of the volume is time-consuming and boring. To solve the problem, we successfully established the liver and spleen volume formula using the body surface area. We compared the liver volume formula with other four formulas, which be proved with highest accuracy and lowest error. Until now, except for the new spleen volume formula in the research, there are few reports about it.AIMTo obtain a reference range of morphological indices, and to establish a formula to accurately predict the standard liver and spleen volumes in Chinese adults.METHODSComputed tomography was used to calculate the estimated total liver volume and spleen volume of 305 Chinese adults without any diseases which could influence the volumes of these two organs. Gender, age, body height, body weight, body surface area and body mass index were determined. Correlation analysis and step-wise multiple linear regression analysis were performed to evaluate the impact of each parameter on the liver and spleen volumes, and then a formula to predict the liver and spleen volumes was established. Finally, the results obtained with the new liver volume formula with existing formulas in a validation group were compared.RESULTSThe average liver and spleen volume values were 1043.18 ± 244.60 cm3 and 175.07 ± 88.15 cm3, respectively. Age, body height, body weight, body surface area and body mass index were significantly correlated with liver and spleen volume. Body surface area showed the strongest correlation with liver volume and spleen volume( p<0.005 and p<0.001). Based on these results, new formulas to calculate the standard liver volume and standard spleen volume were established.CONCLUSIONSCompared the new liver volume formula with the existing formula, it is found that the new liver volume is more accurate. And the accuracy of the spleen volume formula is acceptable. Core tip: To solve the problem of time-consuming and boring in calculating the liver and spleen volume, we successfully established the liver and spleen volume formula can be used in Chinese adult. Though there are some reports about the liver volume, but it is different in spleen volume. The liver volume and spleen volume radio is an useful index to predict the esophageal varices and bleeding risk for cirrhosis patients. Only liver volume formula is not enough, the finding of the spleen volume is very meaningful.

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Non-alcoholic steatohepatitis-related liver cirrhosis is increasing in China: A ten-year retrospective study

Cited by 23 publications

References 30 publications

Epidemiological Features of NAFLD From 1999 to 2018 in China

Epidemiological Features of NAFLD From 1999 to 2018 in China

Study of the sleep quality and psychological state of patients with hepatitis B liver cirrhosis

New formula for predicting standard liver and spleen volumes in Chinese adults

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