The negative prognostic impact of bone metastasis with a tumor mass

Abstract

OBJECTIVE:Typically, bone metastasis causes osteolytic and osteoblastic lesions resulting from the interactions of tumor cells with osteoclasts and osteoblasts. In addition to these interactions, tumor tissues may grow inside bones and cause mass lesions. In the present study, we aimed to demonstrate the negative impact of a tumor mass in a large cohort of patients with bone metastatic cancer.METHODS:Data from 335 patients with bone metastases were retrospectively reviewed. For the analysis, all patients were divided into three subgroups with respect to the type of bone metastasis: osteolytic, osteoblastic, or mixed. The patients were subsequently categorized as having bone metastasis with or without a tumor mass, and statistically significant differences in median survival and 2-year overall survival were observed between these patients (the median survival and 2-year overall survival were respectively 3 months and 16% in patients with a tumor mass and 11 months and 26% in patients without a tumor mass; p<0.001).RESULTS:According to multivariate analysis, the presence of bone metastasis with a tumor mass was found to be an independent prognostic factor (p=0.011, hazard ratio: 1.62, 95% confidence interval: 1.11–1.76). Bone metastasis with a tumor mass was more strongly associated with osteolytic lesions, other primary diseases (except for primary breast and prostate cancers), and spinal cord compression.CONCLUSION:Bone metastasis with a tumor mass is a strong and independent negative prognostic factor for survival in cancer patients.

Clinicopathologic characteristics, metastasis-free survival, and skeletal-related events in 628 patients with skeletal metastases in a tertiary orthopedic and trauma center

“…Nevertheless, our retrospective observational analysis indicated that breast and lung cancer in women, as well as lung and prostate cancer in men, were the most common tumors leading to BM. The distribution patterns of primary tumors among the included patients is in accordance with recently published studies [16,23,31,32]. Osteolytic lesions were predominant in our study cohort, correlating with the results provided by Singh et al [31].…”

“…In a study conducted by Yücel et al, osteoblastic BM lesions were reported to be predominant in patients with lung cancer, prostate, gastrointestinal, and head and neck cancer, whereas osteolytic lesions were predominant in patients with breast and genitourinary cancer [32]. While osteolytic BM lesions are considered to be the most frequent type of bone lesions among different tumor entities, osteoblastic metastases are predominantly found in prostate cancer, which is in accordance with our data [32,33].…”

Paradoxical Role of Glypican-1 in Prostate Cancer Cell and Tumor Growth

“…In addition, we observed high protein expression levels of GPC-1 in metastatic cancer cell lines such as DU-145 and PC-3. PC-3 cells were used as a cell model because they are derived form a bone-marrow metastatic prostate cancer origin, and bone metastases leads to a poor prognosis in prostate cancer patients 37 . Stable transfection of PC-3 cells with shRNA targeting GPC-1 decreased GPC-1 protein expression, as compared to cells transfected with scrambled shRNA as a control (Fig.…”

Hypercalcaemia and hypocalcaemia: finding the balance

“…Although there are clear distinctions in the causes and epidemiology of osteolytic and osteoblastic bone metastases, it should be noted that these two types of bone lesion represent extremes of a spectrum of metastatic bone disease [24]; a substantial proportion of patients have bone metastases with both osteolytic and osteoblastic elements. For example, in one study, the majority of patients with castration-resistant prostate cancer, a spectrum of bone lesions from osteolytic to osteoblastic was present [25].…”