The reduction of serum aminotransferase levels is proportional to the decline of the glomerular filtration rate in patients with chronic kidney disease

Abstract

OBJECTIVE:This study sought to determine the serum aminotransferase levels of patients with predialysis chronic kidney disease and establish their relationships with serum creatinine levels and glomerular filtration rate.METHODS:Patients with chronic kidney disease were evaluated between September 2011 and May 2012. Aminotransferase and creatinine serum levels were measured using an automated kinetic method, and glomerular filtration rates were estimated using the Cockroft-Gault and Modification of Diet in Renal Disease formulas to classify patients into chronic kidney disease stages.RESULTS:Exactly 142 patients were evaluated (mean age: 64±16 years). The mean creatinine serum level and glomerular filtration rate were 3.3±1.2 mg/dL and 29.1±13 mL/min/1.73 m2, respectively. Patients were distributed according to their chronic kidney disease stages as follows: 3 (2.1%) patients were Stage 2; 54 (38%) were Stage 3; 70 (49.3%) were Stage 4; and 15 (10.5%) were Stage 5. The mean aspartate aminotransferase and alanine aminotransferase serum levels showed a reduction in proportion to the increase in creatinine levels (p=0.001 and p=0.05, respectively) and the decrease in glomerular filtration rate (p=0.007 and p=0.028, respectively). Alanine aminotransferase and aspartate aminotransferase serum levels tended to be higher among patients classified as stage 2 or 3 compared with those classified as stage 4 or 5 (p=0.08 and p=0.06, respectively).CONCLUSIONS:The aspartate aminotransferase and alanine aminotransferase serum levels of patients with predialysis chronic kidney disease decreased in proportion to the progression of the disease; they were negatively correlated with creatinine levels and directly correlated with glomerular filtration rate.

A nutraceutical diet based onLespedeza spp.,Vaccinium macrocarponandTaraxacum officinaleimproves spontaneous feline chronic kidney disease

“…A previous study showed that AST serum levels were correlated with creatinine concentration in patients with pre-dialysis CKD (Fabrizi et al 2001). A further study showed that AST and ALT serum levels tended to be higher during the initial stages (2 and 3) of CKD compared with the later stages (4 and 5) (Sette and Lopes 2015). Similarly, in this study, ND significantly decreased AST in cats affected by stage 2 and 3 CKD.…”

“…). A further study showed that AST and ALT serum levels tended to be higher during the initial stages (2 and 3) of CKD compared with the later stages (4 and 5) (Sette and Lopes ). Similarly, in this study, ND significantly decreased AST in cats affected by stage 2 and 3 CKD.…”

Experimental rat model for acute tubular injury induced by high water hardness and high water fluoride: efficacy of primary preventive intervention by distilled water administration

“…Therefore, it is less sensitive and specific for the liver. However, some studies have shown that AST and ALT serum levels tended to be higher during the initial stages (2 and 3) of CKD compared with the later stages (4 and 5) [79]. However, some studies have shown marked inhibitory effect on iron absorption of calcium [80,81] which can accumulate in the liver.…”

Hepatic Enzymes Changes in Chronic Kidney Disease Patients- A Need for Modified Reference Values

“…Moreover, a significant increase in the haematocrit after the HD session was also observed, which provided support for the hypothesis that patients with CKD retain water before HD. 27,28 Huang et al evaluated the serum homocysteine levels of 145 patients undergoing HD and found that they were negatively related to AST. Thus, AST serum levels might reflect the high metabolic activity of homocysteine and influence its serum levels.…”

“…29 Importantly, these hypotheses concern patients with CKD under HD; however, they cannot be rejected with regard to patients during pre-dialysis stages. 28 Some researchers suggested that the aminotransferase serum levels were not related to the dialysis method. Hung et al investigated 90 patients on peritoneal dialysis and healthy adults and found an average ALT level of 15 IU/L in the peritoneal dialysis patients compared with 22 IU/L in the healthy control.…”