Glucosamine and chondroitin sulfate association increases tibial epiphyseal growth plate proliferation and bone formation in ovariectomized rats

Wolff, R

doi:10.6061/clinics/2014(12)10

Cited by 12 publications

(13 citation statements)

References 39 publications

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“…It should be taken into consideration that the hyaline cartilage structure lacks blood supply, does not contain fibrous connective tissue and has a limited number of progenitor cells. Nevertheless, 60-day combined CS+G treatment in female rats subjected to tibial epiphyseal degeneration by ovariectomy resulted in marked chondrocyte proliferation and significant longitudinal bone growth [50]. In the TMJ, however, fibrocartilage may behave similarly to the perichondrium by becoming a source of mesenchymal cells that are precursors of new chondrocytes [51].…”

Section: Discussionmentioning

confidence: 99%

Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine

et al. 2020

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Osteoarthritis is a degenerative disease that causes substantial changes in joint tissues, such as cartilage degeneration and subchondral bone sclerosis. Chondroitin sulfate and glucosamine are commonly used products for the symptomatic treatment of osteoarthritis. The aim of the present study was to investigate the effects of these products when used as structure-modifying drugs on the progression of osteoarthritis in the rabbit temporomandibular joint. Thirty-six New Zealand rabbits were divided into 3 groups (n = 12/group): control (no disease); osteoarthritis (disease induction); and treatment (disease induction and administration of chondroitin sulfate and glucosamine). Osteoarthritis was induced by intra-articular injection of monosodium iodoacetate. Animals were killed at 30 and 90 days after initiation of therapy. The treatment was effective in reducing disease severity, with late effects and changes in the concentration of glycosaminoglycans in the articular disc. The results indicate that chondroitin sulfate and glucosamine may have a structure-modifying effect on the tissues of rabbit temporomandibular joints altered by osteoarthritis. OPEN ACCESSCitation: Artuzi FE, Puricelli E, Baraldi CE, Quevedo AS, Ponzoni D (2020) Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine. PLoS ONE 15(4): e0231734. https://doi.org/ 10.

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Section: Discussionmentioning

confidence: 99%

Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine

et al. 2020

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“…Increasing levels of inclusion of chondroitin and glucosamine sulfates in broiler diets increased the frequency of birds without deviations (valgus and varus) and minimize the with gait score. Chondroitin and glucosamine sulfates are nutraceuticals that have the functions to prevent and treat injuries to the locomotor system ( Kamarul et al., 2011 ; Kantor et al., 2014 ; Wolff, 2014 ; Lubis et al., 2017 ) and reduce pain caused by locomotor problems ( Wolff et al., 2014 ). In addition, these glycosaminoglycans modulate the expression of osteoprotegerin and receptor activator of nuclear factor kappa B ligand, the 2 main factors involved in bone remodeling, with a protective effect on bone loss ( Tat et al., 2007 ).…”

Section: Discussionmentioning

confidence: 99%

“…Polysulfated glycosaminoglycans have prevented and/or reduced the progression of pathologic changes in bone and joint structures of animal models such as rats ( Wen et al., 2010 ; Chiusaroli et al., 2011 ; Jawed et al., 2011 ; Muraleva et al., 2012 ; Arafa et al., 2013 ; Wolff, 2014 ), rabbits ( Herrero-Beaumont et al., 2008 ; Largo et al., 2010 ; Kamarul et al., 2011 ), dogs ( Vieira et al., 2010 ; Eleotéreo et al., 2012 ; Gupta et al., 2012 ; Maxwell et al., 2016 ; Wenz et al., 2017 ), broiler chickens ( Sgavioli et al., 2017 ; Santos et al., 2018 , 2019 ), humans ( Kahan et al., 2009 ; Wildi et al., 2011 ; Kantor et al., 2014 ; Lubis et al., 2017 ), and in vitro ( Tat et al., 2007 ; Varghese et al., 2007 ; Uitterlinden et al., 2008 ; Calamia et al., 2010 , 2012 , 2014 ; Chiusaroli et al., 2011 ; Imagawa et al., 2011 ; Pecchi et al., 2012 ; Cunha et al., 2017 ; Igarashi et al., 2017 ; Kim et al., 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…Among glycosaminoglycans, chondroitin and glucosamine sulfates stand out, which, in combination, stimulate anabolic cartilage processes such as proteoglycan and collagen synthesis ( Kamarul et al., 2011 ), chondrocyte proliferation, bone matrix biosynthesis ( Wolff, 2014 ), and reduce bone resorption ( Maxwell et al., 2016 ). Moreover, they prevent cartilage degeneration through anti-inflammatory and inhibitory mechanisms ( Calamia et al., 2010 , 2014 ; Kantor et al., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Dietary supplementation with glycosaminoglycans reduces locomotor problems in broiler chickens

et al. 2020

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This study aimed to assess the influence of glycosaminoglycan (chondroitin and glucosamine sulfates) supplementation in the diet on the performance and incidence of locomotor problems in broiler chickens. A completely randomized design was carried out in a 3 × 3 factorial scheme (3 levels of chondroitin sulfate −0, 0.05, and 0.10%; and 3 levels of glucosamine sulfate −0, 0.15, and 0.30%). Each treatment was composed of 6 replications of 30 broilers each. The performance of broilers (average weight, weight gain, feed intake, feed conversion, and productive viability) was assessed at 7, 21, 35, and 42 d of age, whereas the gait score, valgus and varus deviations, femoral degeneration, and tibial dyschondroplasia were assessed at 21 and 42 d of age. Increasing levels of glucosamine sulfate inclusion linearly increased the weight gain from 1 to 35 and from 1 to 42 d of age of broilers ( P = 0.047 and P = 0.039, respectively), frequency of broilers with no femoral degeneration in the right and left femurs, and the proliferating cartilage area of proximal epiphysis at 42 d of age ( P = 0.014, P < 0.0001, and P = 0.028, respectively). The increasing inclusion of chondroitin and glucosamine sulfates led to an increase in the frequency of broilers on the gait score scale 0 ( P = 0.007 and P = 0.0001, respectively) and frequency of broilers with no valgus and varus deviations ( P = 0.014 and P = 0.0002, respectively) also at 42 d of age. Thus, chondroitin and glucosamine sulfates can be used in the diet of broiler chickens to reduce their locomotor problems.

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“…There have been controversial reports regarding the effect of GA on cell proliferation; while the inhibitory effect of GA on cell proliferation was reported, other groups showed that GA enhance the cell proliferation …”

Section: Resultsmentioning

confidence: 99%

Enhanced chondrogenic differentiation of stem cells using an optimized electrospun nanofibrous PLLA/PEG scaffolds loaded with glucosamine

Mirzaei

Karkhaneh

Soleimani

et al. 2017

J Biomedical Materials Res

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Recently, tissue engineering has become one of the most important approaches in medical research for the treatment of injuries and lesions. In the present study, poly(l-lactide) acid (PLLA), and polyethylene glycol (PEG) with different ratios and PEG molecular weights were used in order to produce appropriate nanofibrous scaffolds using the electrospinning technique for cartilage tissue engineering applications. Glucosamine was also incorporated into the polymeric scaffolds to enhance the biological properties. Mesenchymal stem cells and chondrocytes were used to monitor the differentiation yield. Water absorption test, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, real-time reverse transcription polymerase chain reaction and mechanical properties analyses were performed to characterize the prepared scaffolds. All fabricated scaffolds had porous and nanofibrous structure with interconnected pores. The PLLA-PEG scaffolds containing PEG with the molecular weights of 3000 and 20,000 and ratio of 85:15 was selected for glucosamine incorporation and cell culture studies due to their superior mechanical properties. According to our data, it was identified that PLLA/PEG 20,000 containing glucosamine had the most capability to support protein absorption, stem cell attachment, and proliferation. Chondrogenic-related genes such as sex-determining region Y-Box 9 (SOX9) and collagen type II were shown to be expressed on these scaffolds higher than those observed on control groups. Taking together, it was demonstrated that in combination with PLLA, PEG 20,000 is a suitable substrate to improve the mechanical and physical properties of nanofibrous scaffolds. In addition, glucosamine-PLLA/PEG 20,000 was shown to support stem cell attachment, proliferation, and chondrogenic differentiation and so holds promising potential for cartilage tissue engineering applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2461-2474, 2017.

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Glucosamine and chondroitin sulfate association increases tibial epiphyseal growth plate proliferation and bone formation in ovariectomized rats

Cited by 12 publications

References 39 publications

Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine

Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine

Dietary supplementation with glycosaminoglycans reduces locomotor problems in broiler chickens

Enhanced chondrogenic differentiation of stem cells using an optimized electrospun nanofibrous PLLA/PEG scaffolds loaded with glucosamine

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