The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease

Vasconcelos, Luciano de Gois; Jackowski, Andrea Parolin; Oliveira, Maira Okada de; Flor, Yoná Mayara Ribeiro; Souza, Altay Alves Lino de; Bueno, Orlando Francisco Amodeo; Brucki, Sônia Maria Dozzi

doi:10.6061/clinics/2014(01)05

Cited by 29 publications

(21 citation statements)

References 55 publications

(60 reference statements)

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“…The isthmus cingulate, which connects the cingulate gyrus to the parahippocampal gyrus, was significantly reduced in ε 4 carriers and in male ε 4 carriers relative to ε 4 non-carriers and male ε 4 non-carriers, respectively ( Sener,1997 ). This finding is supported by previous literature reporting greater atrophy and increased rate of cortical thinning in the isthmus cingulate in AD ( Hayata et al, 2015 ; Mak et al, 2015 ; Vasconcelos et al, 2014 ).…”

Section: Discussionsupporting

confidence: 91%

Older, non-demented apolipoprotein ε4 carrier males show hyperactivation and structural differences in odor memory regions: a blood-oxygen-level-dependent and structural magnetic resonance imaging study

Kapoulea

Murphy

2020

Neurobiology of Aging

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The current study sought to examine the interaction of sex and Apolipoprotein ε 4 status on olfactory recognition memory within non-demented, older individuals. We separated 39 participants into groups based on ε 4 status and sex. Each participant completed an olfactory memory recognition task during 2 functional magnetic resonance imaging scans and 1 structural scan. The ε 4 carriers had greater functional recruitment of memory regions during false positives relative to ε 4 non-carriers. During hits, the male ε 4 carriers showed greater functional recruitment compared to female ε 4 carriers. The ε 4 carriers had larger bilateral putamen volumes relative to ε 4 non-carriers. Neuroimaging data were significantly associated with Dementia Rating Scale scores solely in males. Results suggest differential olfactory memory processing in relation to sex and ε 4 status. Male ε 4 carriers in particular, demonstrated hyperactivation during recognition memory, which we suspect reflects neuronal compensation to maintain functional performance. Future studies should consider examining underlying mechanisms that contribute to these sex differences within ε 4 carriers.

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Section: Discussionsupporting

confidence: 91%

Older, non-demented apolipoprotein ε4 carrier males show hyperactivation and structural differences in odor memory regions: a blood-oxygen-level-dependent and structural magnetic resonance imaging study

Kapoulea

Murphy

2020

Neurobiology of Aging

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“…However, our results showed that the poor performance on the Stroop test was related to not only cortical thinning of prefrontal cortex, but also the thinning of parieto-temporal areas, different from results of prior studies. Luciano has also shown that right superior parietal gyrus and middle temporal gyrus are correlated negatively with scores of the Stroop test in patients with AD 61. In fact, previous studies using different neuroimaging methods have correlated parietal and temporal structures with executive functions 6263.…”

Section: Discussionmentioning

confidence: 93%

The Cortical Neuroanatomy Related to Specific Neuropsychological Deficits in Alzheimer's Continuum

Kang

Park

Lee

et al. 2019

Dement Neurocogn Disord

100

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Background and PurposeIn Alzheimer's continuum (a comprehensive of preclinical Alzheimer's disease [AD], mild cognitive impairment [MCI] due to AD, and AD dementia), cognitive dysfunctions are often related to cortical atrophy in specific brain regions. The purpose of this study was to investigate the association between anatomical pattern of cortical atrophy and specific neuropsychological deficits.MethodsA total of 249 participants with Alzheimer's continuum (125 AD dementia, 103 MCI due to AD, and 21 preclinical AD) who were confirmed to be positive for amyloid deposits were collected from the memory disorder clinic in the department of neurology at Samsung Medical Center in Korea between September 2013 and March 2018. To analyze neuropsychological test-specific neural correlates representing the relationship between cortical atrophy measured by cortical thickness and performance in specific neuropsychological tests, a linear regression analysis was performed. Two neural correlates acquired by 2 different standardized scores in neuropsychological tests were also compared.ResultsCortical atrophy in several specific brain regions was associated with most neuropsychological deficits, including digit span backward, naming, drawing-copying, verbal and visual recall, semantic fluency, phonemic fluency, and response inhibition. There were a few differences between 2 neural correlates obtained by different z-scores.ConclusionsThe poor performance of most neuropsychological tests is closely related to cortical thinning in specific brain areas in Alzheimer's continuum. Therefore, the brain atrophy pattern in patients with Alzheimer's continuum can be predict by an accurate analysis of neuropsychological tests in clinical practice.

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“…Posterior cingulated cortex (PCC) [ 24 ], entorhinal cortex (EC) [ 25 ], hippocampus (HIP) [ 26 ] (the first part to be affected by AD), middle temporal gyrus (MTG) (role in cognitive functions such as language processing), and superior frontal gyrus (SFG) (helps in memory) [ 27 , 28 ] are the regions affected in this multifactorial neurological disorder. Some studies have identified the impaired function of the middle temporal gyrus [ 29 ] and superior frontal gyrus in AD [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Copper Toxicity Links to Pathogenesis of Alzheimer’s Disease and Therapeutics Approaches

Ejaz

Wang

Lang

2020

IJMS

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Alzheimer’s disease (AD) is an irreversible, age-related progressive neurological disorder, and the most common type of dementia in aged people. Neuropathological lesions of AD are neurofibrillary tangles (NFTs), and senile plaques comprise the accumulated amyloid-beta (Aβ), loaded with metal ions including Cu, Fe, or Zn. Some reports have identified metal dyshomeostasis as a neurotoxic factor of AD, among which Cu ions seem to be a central cationic metal in the formation of plaque and soluble oligomers, and have an essential role in the AD pathology. Cu-Aβ complex catalyzes the generation of reactive oxygen species (ROS) and results in oxidative damage. Several studies have indicated that oxidative stress plays a crucial role in the pathogenesis of AD. The connection of copper levels in AD is still ambiguous, as some researches indicate a Cu deficiency, while others show its higher content in AD, and therefore there is a need to increase and decrease its levels in animal models, respectively, to study which one is the cause. For more than twenty years, many in vitro studies have been devoted to identifying metals’ roles in Aβ accumulation, oxidative damage, and neurotoxicity. Towards the end, a short review of the modern therapeutic approach in chelation therapy, with the main focus on Cu ions, is discussed. Despite the lack of strong proofs of clinical advantage so far, the conjecture that using a therapeutic metal chelator is an effective strategy for AD remains popular. However, some recent reports of genetic-regulating copper transporters in AD models have shed light on treating this refractory disease. This review aims to succinctly present a better understanding of Cu ions’ current status in several AD features, and some conflicting reports are present herein.

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The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease

Cited by 29 publications

References 55 publications

Older, non-demented apolipoprotein ε4 carrier males show hyperactivation and structural differences in odor memory regions: a blood-oxygen-level-dependent and structural magnetic resonance imaging study

Older, non-demented apolipoprotein ε4 carrier males show hyperactivation and structural differences in odor memory regions: a blood-oxygen-level-dependent and structural magnetic resonance imaging study

The Cortical Neuroanatomy Related to Specific Neuropsychological Deficits in Alzheimer's Continuum

Copper Toxicity Links to Pathogenesis of Alzheimer’s Disease and Therapeutics Approaches

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