Gender differences in microcirculation: Observation using the hamster cheek pouch

Panazzolo, Diogo G.; Silva, Lucia Henriques Alves da; Cyrino, Fátima Z. G. A.; Sicuro, Fernando Lencastre; Kraemer‐Aguiar, Luiz Guilherme

doi:10.6061/clinics/2013(12)10

Cited by 13 publications

(10 citation statements)

References 31 publications

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“…11 A difference in vascular permeability was also observed between the genders during flap surgery 11 and after ischemia/reperfusion in the cheek pouch of a hamster. 48 Another important phenomenon, namely "collateralization" (or arteriogenesis)-which maintains perfusion in case of reduced vascularity before neovascularization can be completed-is also influenced by gender in the different tissues. [49][50][51] These findings suggest that wound healing might be influenced by gender, too.…”

Section: Discussionmentioning

confidence: 99%

Functional characterization of collaterals in the human gingiva by laser speckle contrast imaging

et al. 2018

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Objective The rate of blood flow between the various areas of the gingiva in resting position and under challenge is unknown. In this study, the LSCI method was used to map spatial and temporal changes in gingival blood flow after transient compression. Methods Horizontal, vertical, and papilla base compressions were applied on the attached gingiva in 21 healthy patients (13 women, 8 men). LSCI was used to determine dynamic changes in regional blood flow during a five‐second occlusion interval and subsequent reperfusion for twenty minutes. Results Resting blood flow in the attached gingiva apical to the papillae was higher as compared to that in the midbuccal area of the teeth. During short‐term horizontal compression, ischemia was greater coronal than apical to the occlusion line. Postocclusive hyperemia was observed not only in the regions affected by ischemia but encompassed a wider area. Hyperemic response was more pronounced and prolonged in male than in female patients. Conclusions Blood flow in the attached gingiva shows spatial differences. Our findings corroborate the apicocoronal orientation of blood circulation. Periodontal and papillary collaterals may have little role in the blood supply of the adjacent attached gingiva under physiological conditions.

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Section: Discussionmentioning

confidence: 99%

Functional characterization of collaterals in the human gingiva by laser speckle contrast imaging

et al. 2018

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“…Under basal conditions observations of in situ venular perfusion demonstrate no discernable difference between males and females with respect to WBC/EC interactions in the hamster cheek pouch [89]. While basal white cell/EC interactions did not differ in this preparation, permeability responses to ischemia/reperfusion (I/R) injury in the venous vasculature did.…”

Section: Venulesmentioning

confidence: 97%

“…Sex differences with respect to the primary function of capillary endothelial cells, fluid and solute exchange, have been demonstrated at multiple levels in a limited number of studies [15, 53, 54, 74, 89, 104, 112, 116]. In each it becomes evident that the differences can reflect the driving forces for exchange, EC morphology, and cell signaling, as well as EC responses to a myriad of mediators.…”

Section: Sexual Dimorphism In Capillary Functionmentioning

confidence: 99%

“…While basal white cell/EC interactions did not differ in this preparation, permeability responses to ischemia/reperfusion (I/R) injury in the venous vasculature did. Following the I/R insult, fluorescently labeled dextrans were observed to egress more from the venules of males relative to the females clearly demonstrating that the loss of barrier function was apparently independent of WBC/EC interactions [89]. …”

Section: Venulesmentioning

confidence: 99%

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Sex-Specific Characteristics of the Microcirculation

Huxley

Kemp

2018

Advances in Experimental Medicine and Biology

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The requirements of metabolizing tissue are both continuous and variable; accordingly, the microvasculature serving that tissue must be similarly dynamic. Just as it is recognized that males and females of the same species have differing metabolic requirements, is it not likely that the microvasculature serving these tissues will differ by sex? This section focusing on the constituents of the microcirculation identifies what is known presently about the role sex plays in matching metabolic demand with microvascular function and areas requiring additional study. Many of the identified sex differences are subtle and easily ignored. In the aggregate, though, they can profoundly alter phenotype, especially under stressful conditions including pregnancy, exercise, and disease states ranging from diabetes to heart failure. Although the features presently identified to “have sex” range from differences in growth, morphology, protein expression, and intracellular signaling, males and females alike achieve homeostasis, likely by different means. Studies of microvascular sexual dimorphism are also identifying age as an independent but interacting factor requiring additional attention. Overall, attempting to ignore either sex and/or age is inappropriate and will prevent the design and implementation of appropriate interventions to present, ameliorate, or correct microvascular dysfunction.

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“…A common model for animal studies is the hamster cheek pouch, which has a highly vascularised cutaneous microcirculatory bed (Panazzolo et al, 2013). Likewise, the rat cremaster muscle is used (Eringa et al, 2002;Eringa et al, 2007).…”

Section: Experimental Models For Studying Microvascular Functionmentioning

confidence: 99%

Assessment of microvascular and metabolic responses in the skin

Iredahl¹

2016

Linköping University Medical Dissertations

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The general aim of this project was to develop experimental in vivo models that allow for minimally invasive investigations of responses in the skin to microvascular and metabolic provocations. The cutaneous microvasculature has emerged as a valuable model and been proposed to mirror the microcirculation in other organs. Dysfunction in the cutaneous microcirculation has thus been linked to systemic diseases such as hypertension and diabetes mellitus. Models for investigating skin responses could facilitate the understanding of pathophysiological mechanisms as well as effects of drugs. In the first study, three optical measurement techniques (laser Doppler flowmetry (LDF), laser speckle contrast imaging (LSCI) and tissue viability imaging (TiVi)) were compared against each other and showed differences in their ability to detect microvascular responses to provocations in the skin. TiVi was found more sensitive for measurement of noradrenaline-induced vasoconstriction, while LSCI was more sensitive for measurement of vascular occlusion. In the second study, microvascular responses in the skin to iontophoresis of vasoactive drugs were found to depend on the drug delivery protocol. Perfusion half-life was defined and used to describe the decay in the microvascular response to a drug after iontophoresis. In the third study, the role of nitric oxide (NO) was assessed during iontophoresis of insulin. The results showed a NO-dependent vasodilation in the skin by insulin. In the fourth study the vasoactive and metabolic effects of insulin were studied after both local and endogenous administration. Local delivery of insulin increased skin blood flow, paralleled by increased skin concentrations of interstitial pyruvate and lactate, although no change in glucose concentration was observed. An oral glucose load resulted in an increased insulin concentration in the skin paralleled by an increase in blood flow, as measured using the microdialysis urea clearance technique, although no changes in perfusion was measured by LSCI. The thesis concludes that when studying skin microvascular responses, the choice of measurement technique and the drug delivery protocol has an impact on the measurement results, and should therefore be carefully considered. The thesis also concludes that insulin has metabolic and vasodilatory effects in the skin both when administered locally and as an endogenous response to an oral glucose load. The vasodilatory effect of insulin in the skin is mediated by nitric oxide

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Gender differences in microcirculation: Observation using the hamster cheek pouch

Cited by 13 publications

References 31 publications

Functional characterization of collaterals in the human gingiva by laser speckle contrast imaging

Functional characterization of collaterals in the human gingiva by laser speckle contrast imaging

Sex-Specific Characteristics of the Microcirculation

Assessment of microvascular and metabolic responses in the skin

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