Expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on osteoclasts and its potential role in rheumatoid arthritis

Zhang, Yuan; Ding, Yong; Huang, Yi You; Zhang, Chunmei; Jin, Boquan; Zhuang, Ran

doi:10.6061/clinics/2013(04)07

Cited by 20 publications

(20 citation statements)

References 21 publications

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“…Inhibitory cellular effects have been observed upon stimulation of LAIR-1 with collagen [22,32]. It is particularly interesting, that osteoclasts express both the stimulatory collagen receptor OSCAR [28] and an inhibitory receptor LAIR-1 [34]. However, if we assume that OSCAR and LAIR-1 are expressed at different stages of osteoclastogenesis, we can attempt to reconcile how contradictory collagen signals can be perceived by these cells.…”

Section: Receptors Potentially Activated By Matrix-incorporated Collagenmentioning

confidence: 99%

“…It is thus possible that additional regulation may be exerted by this receptor present on mature osteoblasts. From the LRC family, OSCAR and LAIR-1 have been shown to be expressed by osteoclasts [28,34]. It is possible that LAIR-1-mediated inhibition of osteoclastogenesis contributes to the prevention of premature activation of resorption at the sites of freshly laid down osteoid.…”

Section: Receptors Potentially Activated By Triple-helical Collagenmentioning

confidence: 99%

“…Both LAIR-1 and G6b-B were first identified to be expressed on megakaryocytes and platelets and to negatively regulate their function [22,33]. LAIR-1 was also found to be present during osteoclastogenesis and to inhibit this process [34]. LAIR-1 is activated by triple helical collagen, specifically when it encounters the triplet (GPO) 10 (glycine-proline-hydroxyproline) 10 , also known as "collagen related peptide" [31].…”

Section: Leukocyte Receptor Complex (Lrc)mentioning

confidence: 99%

“…Such fragments can potentially activate the receptors of LRC, GPVI, LAIR-1, and G6b-B, as well as uPARAP/Endo180. Since LAIR-1 is expressed by osteoclasts [34] and uPARAP/Endo180 by osteoblasts [129], it is possible that such signals mediate temporal and spatial coordination of collagen matrix formation and degradation. In addition, formation of circulating fragments, such as those used as biomarkers of bone resorption [130], raises a possibility of long-distance signals generated during collagen degradation.…”

Section: Receptors Potentially Activated By Degraded Collagenmentioning

confidence: 99%

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Collagen Type I as a Ligand for Receptor-Mediated Signaling

et al. 2017

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Collagens form the fibrous component of the extracellular matrix in all multi-cellular animals. Collagen type I is the most abundant collagen present in skin, tendons, vasculature, as well as the organic portion of the calcified tissue of bone and teeth. This review focuses on numerous receptors for which collagen acts as a ligand, including integrins, discoidin domain receptors DDR1 and 2, OSCAR, GPVI, G6b-B, and LAIR-1 of the leukocyte receptor complex (LRC) and mannose family receptor uPARAP/Endo180. We explore the process of collagen production and self-assembly, as well as its degradation by collagenases and gelatinases in order to predict potential temporal and spatial sites of action of different collagen receptors. While the interactions of the mature collagen matrix with integrins and DDR are well-appreciated, potential signals from immature matrix as well as collagen degradation products are possible but not yet described. The role of multiple collagen receptors in physiological processes and their contribution to pathophysiology of diseases affecting collagen homeostasis require further studies.

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Section: Receptors Potentially Activated By Matrix-incorporated Collagenmentioning

confidence: 99%

Section: Receptors Potentially Activated By Triple-helical Collagenmentioning

confidence: 99%

Section: Leukocyte Receptor Complex (Lrc)mentioning

confidence: 99%

Section: Receptors Potentially Activated By Degraded Collagenmentioning

confidence: 99%

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Collagen Type I as a Ligand for Receptor-Mediated Signaling

et al. 2017

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“…It is broadly expressed on nearly all immune cells, such as T-cells, B-cells, and NK cells; however, it is not expressed on erythrocytes and platelets (7). It is also expressed on megakaryocytes (MKs) (8) and osteoclasts (9). Poggi et al (10) demonstrated that LAIR-1 was not expressed in high-risk B-cell chronic lymphocytic leukemia (CLL), and the intensity of expression in low- and intermediate-risk CLL was associated with the CLL stage and progression of the disease.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of leukocyte-associated immunoglobulin-like receptor-1 expression in human cervical cancer

Wang

Zhang

Miao

et al. 2016

Experimental and Therapeutic Medicine

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Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is broadly expressed on the majority of immune cells; however, the biological role of LAIR in solid tumors has yet to be elucidated. In the present study, using immunohistochemical staining analysis, the expression of LAIR-1 in human cervical cancer (HCC) and nontumor-adjacent tissue specimens was determined, and the results indicated that the expression of LAIR-1 in HCC tissue was higher compared with that in noncancerous tissue. The χ2 test was used to analyze the correlation between the expression of LAIR-1 in tumor tissues with clinicopathological parameters. The results showed that the expression of LAIR-1 in the cancer cell nucleus was significantly associated with tumor size, pathological differentiation, T classification and clinical stage. In addition, the expression in the cytoplasm was evidently associated with the number of positive lymph nodes. The HCC cell line, ME-180, which does not express LAIR-1, was stably transfected using LAIR-1 cDNA. Cell Counting Kit-8 and an annexin V assay showed that the overexpression of LAIR-1 in ME-180 cells suppressed the proliferation and anti-apoptosis capacity of the cells. These findings demonstrated that LAIR-1 is markedly overexpressed in HCC tissue, and that its expression status is associated with tumor progression. LAIR-1 may be a biomarker and target in the diagnosis and treatment of patients with HCC.

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Differential gene expression levels might explain association of LAIR2 polymorphisms with pemphigus

2015

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The leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) is a collagen-binding inhibitory receptor important for the regulation of immune responses, expressed on the majority of peripheral blood mononuclear cells (PBMC). LAIR-2 is a soluble homolog that antagonizes LAIR-1 inhibitory function by binding the same ligands. We sought to investigate whether LAIR1 and LAIR2 single nucleotide polymorphisms (SNP) are associated with differential mRNA expression levels. We analyzed 14 SNPs of LAIR1 (6) and LAIR2 (8) by mass spectrometry-based genotyping and extracted mRNA from PBMC of 177 healthy subjects, followed by quantitative assays. Four SNPs of LAIR1 and two SNPs of LAIR2 mark differential mRNA levels in healthy individuals. To verify the biological relevance of these findings, we analyzed additional 515 individuals (282 patients and 233 controls) to check if LAIR1 and LAIR2 differential mRNA expression could be related to susceptibility to pemphigus foliaceus (PF), an autoimmune blistering skin disease endemic in Brazil. Two LAIR1 variants (rs56802430 G, OR = 1.52, p = 0.0329; rs11084332 C, OR = 0.57, p = 0.0022) and one LAIR2 (rs2287828 T+, OR = 1.9, p = 0.0097) contribute to differential susceptibility to PF. Furthermore, we demonstrate interactions among four LAIR2 SNPs (rs2042287, rs2287828, rs2277974 and rs114834145). A haplotype harboring these SNPs is strongly associated with higher LAIR2 mRNA levels (4.5-fold, p = 0.0069) and with higher susceptibility to PF (OR = 4.02, p = 0.0008). We suggest that LAIR1 and LAIR2 genetic variants are associated with regulation of gene expression and variable PF susceptibility, and show indirect association of LAIR2 differential mRNA expression with PF pathogenesis. Our data demonstrate how this relatively unknown disease can add invaluable knowledge regarding the role of LAIR1 and LAIR2 in immune responses.

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Expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on osteoclasts and its potential role in rheumatoid arthritis

Cited by 20 publications

References 21 publications

Collagen Type I as a Ligand for Receptor-Mediated Signaling

Collagen Type I as a Ligand for Receptor-Mediated Signaling

Clinical significance of leukocyte-associated immunoglobulin-like receptor-1 expression in human cervical cancer

Differential gene expression levels might explain association of LAIR2 polymorphisms with pemphigus

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