Evaluation of the mean platelet volume in patients with cardiac syndrome X

Abstract

OBJECTIVE:Cardiac syndrome X is characterized by angina-like chest pain, a positive stress test, and normal coronary arteries. A patient's mean platelet volume, which potentially reflects platelet function and activity, is associated with coronary atherosclerosis and endothelial dysfunction. The aim of the present study was to evaluate the mean platelet volumes of patients with cardiac syndrome X, those with coronary artery disease and normal subjects.METHODS:Two hundred thirty-six subjects (76 patients with cardiac syndrome X, 78 patients with coronary artery disease, and 82 controls) were enrolled in the study. All of the subjects were evaluated with a detailed medical history, physical examination, and biochemical analyses. The mean platelet volumes were compared between the three groups.RESULTS:The mean platelet volumes in the patients with cardiac syndrome X and with coronary artery disease were significantly higher than those that were observed in the control group. There were no significant differences in the mean platelet volumes between the cardiac syndrome X and the coronary artery disease groups.CONCLUSION:We have established that patients with cardiac syndrome X and coronary artery disease exhibit higher mean platelet volumes compared to controls. Patients with cardiac syndrome X exhibited higher mean platelet volumes compared to the controls, reflecting the presence of subclinical atherosclerosis. These findings suggest that, in addition to endothelial dysfunction, the presence of atherosclerosis may also contribute to the etiopathogenesis of cardiac syndrome X.

Ortalama Platelet Hacmi İle Gated Myokard Perfüzyon Spect Sintigrafisinden Elde Edilen Parametrelerin İlişkisi

“…Demirkol ve arkadaşlarının yaptığı çalışmada kardiyak sendrom X hastalarında ortalama platelet hacminin değerlendirilmesi amaçlanmış. 236 hasta (76 kardiyak sendrom X olan, 78 koroner arter hastalığı olan ve 82 kontrol grubu hasta) çalışmaya alınmış; kardiyak sendrom X ve koroner arter hastalığı olan hastalarda MPV kontrol grubuna göre anlamlı olarak yüksek bulunmuştur (14). Şahin ve arkadaşlarının yaptığı çalışmada Primer perkütan koroner girişim uygulanan 912 ST yükselmeli miyokard infarktüs (STEMİ) hastası çalışmaya alınmış.…”

Helicobacter pylori infection and homocysteine levels in patients with cardiac syndrome X

“…CSX has 3 characteristic features; angina or angina like chest pain with exertion, ST segment depression that can be induced by treadmill exercise testing, or alternatively, a pathological thallium scan with normal coronary arteriography, and no spontaneous or inducible epicardial coronary artery spasm upon ergonovine or acetylcholine provocation [2].…”

Hemostatic markers can be pivotal roles of risk factors for new-onset atrial fibrillation

“…MPV is one of the most widely used laboratory markers related to the platelet function based on inflammatory conditions [13,14]. MPV also indicates the function of platelet, which is central to processes that are involved in coronary heart disease pathophysiology and endothelial dysfunction [15,16]. Platelet paremeters can be affected by coronary risk factors, including age, obesity, smoking, diabetes mellitus, hypertension, and hyperlipidemia metabolic syndrome [14].…”